{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T19:21:51Z","timestamp":1771788111720,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bja.2021.02.033","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T06:32:02Z","timestamp":1619159522000},"page":"1111-1118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Induced normothermia ameliorates the procoagulant host response in human endotoxaemia"],"prefix":"10.1016","volume":"126","author":[{"given":"Matthew B.A.","family":"Harmon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanon F.L.","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"de Bruin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niek H.","family":"Sperna Weiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost C.M.","family":"Meijers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole P.","family":"Juffermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2021.02.033_bib1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2021.02.033_bib2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00134-004-2166-z","article-title":"Body temperature alterations in the critically ill","volume":"30","author":"Peres Bota","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2021.02.033_bib3","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S1286-4579(00)01337-X","article-title":"The role of fever in the infected host","volume":"2","author":"Hasday","year":"2000","journal-title":"Microbe. Infect"},{"key":"10.1016\/j.bja.2021.02.033_bib4","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1164\/rccm.201110-1820OC","article-title":"Fever control using external cooling in septic shock: a randomized controlled trial","volume":"185","author":"Schortgen","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2021.02.033_bib5","doi-asserted-by":"crossref","first-page":"3906032","DOI":"10.1155\/2017\/3906032","article-title":"Effects of target temperature management on the outcome of septic patients with fever","volume":"2017","author":"Gao","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bja.2021.02.033_bib6","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","article-title":"Mechanisms of action, physiological effects, and complications of hypothermia","volume":"37","author":"Polderman","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2021.02.033_bib7","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1096\/fasebj.5.12.1916089","article-title":"Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction","volume":"5","author":"Raetz","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.bja.2021.02.033_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/infdis\/144.4.329","article-title":"Properties of reference Escherichia coli endotoxin and its phthalylated derivative in humans","volume":"144","author":"Elin","year":"1981","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.bja.2021.02.033_bib9","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/01.ATV.19.10.2517","article-title":"Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen","volume":"19","author":"Pernerstorfer","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bja.2021.02.033_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00464-013-3203-1","article-title":"Clinical markers of the hypercoagulable state by rotational thrombelastometry in obese patients submitted to bariatric surgery","volume":"28","author":"Taura","year":"2014","journal-title":"Surg Endosc"},{"key":"10.1016\/j.bja.2021.02.033_bib11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/jth.12155","article-title":"Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines","volume":"11","author":"Wada","year":"2013","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.bja.2021.02.033_bib12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00000542-199309000-00009","article-title":"Clonidine comparably decreases the thermoregulatory thresholds for vasoconstriction and shivering in humans","volume":"79","author":"Delaunay","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2021.02.033_bib13","doi-asserted-by":"crossref","first-page":"R248","DOI":"10.1186\/cc10506","article-title":"Surface cooling for induction of mild hypothermia in conscious healthy volunteers - a feasibility trial","volume":"15","author":"Testori","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.02.033_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/MPA.0b013e318162cb26","article-title":"Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia","volume":"37","author":"Fujimoto","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.bja.2021.02.033_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13054-015-0918-5","article-title":"Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study","volume":"19","author":"Ostrowski","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.02.033_bib16","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1160\/TH03-04-0245","article-title":"Regulation of protease-activated receptor 1 (PAR1) on platelets and responsiveness to thrombin receptor activating peptide (TRAP) during systemic inflammation in humans","volume":"90","author":"Reiter","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.bja.2021.02.033_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/09537104.2015.1119814","article-title":"Platelet activation at the onset of human endotoxemia is undetectable in\u00a0vivo","volume":"27","author":"Schrottmaier","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.bja.2021.02.033_bib18","first-page":"185","article-title":"Transient pulmonary platelet sequestration during endotoxemia in dogs","volume":"21","author":"Gutmann","year":"1987","journal-title":"Circ Shock"},{"key":"10.1016\/j.bja.2021.02.033_bib19","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1538-7836.2003.00237.x","article-title":"Procoagulant protein levels are differentially increased during human endotoxemia","volume":"1","author":"Reitsma","year":"2003","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.bja.2021.02.033_bib20","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.thromres.2007.03.011","article-title":"The role of von Willebrand factor in thrombus formation","volume":"120","author":"Ruggeri","year":"2007","journal-title":"Thromb Res"},{"key":"10.1016\/j.bja.2021.02.033_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2516.2008.01848.x","article-title":"Function of von Willebrand factor in haemostasis and thrombosis","volume":"14","author":"Reininger","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.bja.2021.02.033_bib22","doi-asserted-by":"crossref","first-page":"R30","DOI":"10.1186\/cc13721","article-title":"Utility of thromboelastography and or thromboelastometry in adults with sepsis: a systematic review","volume":"18","author":"Muller","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.02.033_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5482\/HAMO-12-05-0011","article-title":"Thromboelastometry guided therapy of severe bleeding. Essener Runde algorithm","volume":"33","author":"Lier","year":"2013","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.bja.2021.02.033_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/MBC.0000000000000808","article-title":"Thromboelastometry in critically ill patients with disseminated intravascular coagulation","volume":"30","author":"Muller","year":"2019","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.bja.2021.02.033_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12011-015-0406-4","article-title":"Prevalence of thrombocytopenia and its association with serum magnesium","volume":"169","author":"Lu","year":"2016","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.bja.2021.02.033_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/bja\/aep336","article-title":"L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate","volume":"104","author":"Lin","year":"2010","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2021.02.033_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jri.2006.06.004","article-title":"Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway","volume":"73","author":"Rochelson","year":"2007","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.bja.2021.02.033_bib28","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/cc3004","article-title":"Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study","volume":"9","author":"Esen","year":"2005","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.02.033_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1292\/jvms.63.467","article-title":"Enhanced production of IL-1 beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency","volume":"63","author":"Nakagawa","year":"2001","journal-title":"J\u00a0Vet Med Sci"},{"key":"10.1016\/j.bja.2021.02.033_bib30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.HYP.0000146536.68208.84","article-title":"Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings","volume":"44","author":"Shimosawa","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.bja.2021.02.033_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1211\/0022357022593","article-title":"The effects of imidazoline agents on the aggregation of human platelets","volume":"56","author":"Pinthong","year":"2004","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.bja.2021.02.033_bib32","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-3565(25)31581-8","article-title":"The effects of alpha adrenergic agents on human platelet aggregation","volume":"208","author":"Hsu","year":"1979","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.bja.2021.02.033_bib33","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jclinane.2004.11.004","article-title":"The effect of clonidine on perioperative blood coagulation","volume":"17","author":"Ganter","year":"2005","journal-title":"J\u00a0Clin Anesth"},{"key":"10.1016\/j.bja.2021.02.033_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s13054-019-2690-4","article-title":"The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies","volume":"23","author":"Flanders","year":"2019","journal-title":"Crit Care"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091221001732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091221001732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T18:59:42Z","timestamp":1757789982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091221001732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0007091221001732"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2021.02.033","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induced normothermia ameliorates the procoagulant host response in human endotoxaemia","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2021.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}