{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:23Z","timestamp":1792180643562,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010727","name":"Axel Muusfeldts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bja.2021.06.031","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T01:27:05Z","timestamp":1628645225000},"page":"521-531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Goal-directed fluid therapy in emergency abdominal surgery: a randomised multicentre trial"],"prefix":"10.1016","volume":"127","author":[{"given":"Anne A.","family":"Aaen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders W.","family":"Voldby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Kildsig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon G.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Zimmermann-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Tib\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Brandstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2021.06.031_bib1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/00365521.2012.746393","article-title":"Long-term mortality following peptic ulcer perforation in the PULP trial. A nationwide follow-up study","volume":"48","author":"M\u00f8ller","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.bja.2021.06.031_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/bjs.9749","article-title":"Randomized multicentre feasibility trial of intermediate care versus standard ward care after emergency abdominal surgery (InCare trial)","volume":"102","author":"Vester-Andersen","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/bja\/aes165","article-title":"Variations in mortality after emergency laparotomy: the first report of the UK Emergency Laparotomy Network","volume":"109","author":"Saunders","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2021.06.031_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1308\/rcsann.2013.95.8.599","article-title":"UK practice in emergency laparotomy","volume":"95","author":"Barrow","year":"2013","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.bja.2021.06.031_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00068-014-0450-3","article-title":"30-Day and 1-year mortality in emergency general surgery laparotomies: an area of concern and need for improvement?","volume":"41","author":"Watt","year":"2015","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib6","series-title":"Annual report 2015. Akut kir database","article-title":"Danish clinical register of emergency surgery for peptic ulcer","author":"J\u00f8rgensen","year":"2016"},{"key":"10.1016\/j.bja.2021.06.031_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijsu.2008.03.002","article-title":"Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696)","volume":"6","author":"Harten","year":"2008","journal-title":"Int J Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10877-015-9691-x","article-title":"Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial","volume":"30","author":"Pavlovic","year":"2016","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.bja.2021.06.031_bib9","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/bja\/aef220","article-title":"Pathophysiology and clinical implications of perioperative fluid excess","volume":"89","author":"Holte","year":"2002","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2021.06.031_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000542-200507000-00008","article-title":"Effect of intraoperative fluid management on outcome after intraabdominal surgery","volume":"103","author":"Nisanevich","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2021.06.031_bib11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0035-1548736","article-title":"Restrictive versus standard fluid regimen in elective minilaparotomy abdominal aortic repair\u2014prospective randomized controlled trial","volume":"64","author":"Piljic","year":"2015","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/SLA.0b013e31818b73dc","article-title":"Impact of different crystalloid volume regimes on intestinal anastomotic stability","volume":"249","author":"Marjanovic","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib13","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/01.sla.0000094387.50865.23","article-title":"Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial","volume":"238","author":"Brandstrup","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/aas.12651","article-title":"Enhanced Recovery after Surgery (ERAS) for gastrointestinal surgery: Part 2. Consensus statement for anaesthesia practice","volume":"60","author":"Feldheiser","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2021.06.031_bib15","series-title":"Consort \u2014 Welcome to the CONSORT Website","year":"2010"},{"key":"10.1016\/j.bja.2021.06.031_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022651","article-title":"Goal-directed fluid therapy in urgent GAstrointestinal Surgery\u2014study protocol for a randomised multicentre trial: the GAS-ART trial","volume":"8","author":"Voldby","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.bja.2021.06.031_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/bja\/aes163","article-title":"Which goal for fluid therapy during colorectal surgery is followed by the best outcome: near-maximal stroke volume or zero fluid balance?","volume":"109","author":"Brandstrup","year":"2012","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2021.06.031_bib18","unstructured":"Team Rs. RStudio: integrated development environment for R. [cited 2018 Aug 17]. Available from: http:\/\/www.rstudio.com\/."},{"key":"10.1016\/j.bja.2021.06.031_bib19","first-page":"CD012767","article-title":"Perioperative restrictive versus goal-directed fluid therapy for adults undergoing major non-cardiac surgery","volume":"12","author":"Wrzosek","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bja.2021.06.031_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJMoa021108","article-title":"A\u00a0randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients","volume":"348","author":"Sandham","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2021.06.031_bib21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2044.2002.02708.x","article-title":"Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery","volume":"57","author":"Conway","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2021.06.031_bib22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1213\/ANE.0000000000000295","volume":"119","author":"Pesta\u00f1a","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2021.06.031_bib23","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1001\/jama.2014.5305","article-title":"Effect of a perioperative, cardiac output\u2013guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery","volume":"311","author":"Pearse","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2021.06.031_bib24","doi-asserted-by":"crossref","first-page":"R118","DOI":"10.1186\/cc9070","article-title":"Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study","volume":"14","author":"Benes","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.06.031_bib25","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1186\/cc10284","article-title":"Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis","volume":"15","author":"Dalfino","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.06.031_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/bjs.10427","article-title":"Multidisciplinary perioperative protocol in patients undergoing acute high-risk abdominal surgery","volume":"104","author":"Tengberg","year":"2017","journal-title":"Br J Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/bjs.9658","article-title":"Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy","volume":"102","author":"Huddart","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/bjs.5454","article-title":"Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection","volume":"93","author":"Noblett","year":"2006","journal-title":"Br J Surg"},{"key":"10.1016\/j.bja.2021.06.031_bib29","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/cc12885","article-title":"Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative complications after major abdominal surgery: a multi-center, prospective, randomized study","volume":"17","author":"Salzwedel","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2021.06.031_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1308\/rcsann.2017.0229","article-title":"Impact of laparoscopic approach in emergency major abdominal surgery: single-centre analysis of 748 consecutive cases","volume":"100","author":"Pucher","year":"2018","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.bja.2021.06.031_bib31","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/s00134-006-0195-5","article-title":"Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery","volume":"32","author":"Verheij","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2021.06.031_bib32","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa1209759","article-title":"Hydroxyethyl starch or saline for fluid resuscitation in intensive care","volume":"367","author":"Myburgh","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2021.06.031_bib33","first-page":"CD000567","article-title":"Colloids versus crystalloids for fluid resuscitation in critically ill patients","volume":"2","author":"Perel","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bja.2021.06.031_bib34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1056\/NEJMoa1204242","article-title":"Hydroxyethyl starch 130\/0.42 versus Ringer\u2019s acetate in severe sepsis","volume":"367","author":"Perner","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2021.06.031_bib35","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/bja\/aei223","article-title":"Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery","volume":"95","author":"Wakeling","year":"2005","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2021.06.031_bib36","series-title":"Fifth Patient NELA report","year":"2019"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091221004207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091221004207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:15:28Z","timestamp":1762103728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091221004207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0007091221004207"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2021.06.031","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Goal-directed fluid therapy in emergency abdominal surgery: a randomised multicentre trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2021.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}