{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:20:39Z","timestamp":1758050439155,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.bja.2022.05.007","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T07:18:09Z","timestamp":1655536689000},"page":"150-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simulation to minimise patient self-inflicted lung injury: are we almost there?"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-5388","authenticated-orcid":false,"given":"Vasiliki","family":"Tsolaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-0967","authenticated-orcid":false,"given":"George E.","family":"Zakynthinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2022.05.007_bib1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.bja.2022.02.037","article-title":"Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study","volume":"128","author":"Weaver","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.05.007_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12890-017-0369-7","article-title":"Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome","volume":"17","author":"Das","year":"2017","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.bja.2022.05.007_bib3","first-page":"2729","article-title":"Creating virtual ARDS patients","volume":"2016","author":"Das","year":"2016","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.bja.2022.05.007_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13054-014-0723-6","article-title":"Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation","volume":"19","author":"Das","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2022.05.007_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40635-015-0068-8","article-title":"Computational simulation indicates that moderately high-frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients","volume":"3","author":"Wang","year":"2015","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.bja.2022.05.007_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13613-021-00904-7","article-title":"High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study","volume":"11","author":"Weaver","year":"2021","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2022.05.007_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.SIH.0000258411.38212.32","article-title":"The future vision of simulation in healthcare","volume":"2","author":"Gaba","year":"2007","journal-title":"Simul Healthc"},{"key":"10.1016\/j.bja.2022.05.007_bib8","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/00003246-200402001-00010","article-title":"From Resusci-Anne to Sim-Man: the evolution of simulators in medicine","volume":"32","author":"Grenvik","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2022.05.007_bib9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.chest.2019.07.011","article-title":"Simulation training in the ICU","volume":"156","author":"Seam","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.bja.2022.05.007_bib10","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1128\/AAC.00633-16","article-title":"Phase 2, dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection","volume":"60","author":"Lucasti","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bja.2022.05.007_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/cts.13158","article-title":"Population pharmacokinetic\/pharmacodynamic assessment of imipenem\/cilastatin\/relebactam in patients with hospital-acquired\/ventilator-associated bacterial pneumonia","volume":"15","author":"Patel","year":"2022","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.bja.2022.05.007_bib12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmpb.2010.03.009","article-title":"Intelligent model-based advisory system for the management of ventilated intensive care patients: Part II. Advisory system design and evaluation","volume":"99","author":"Wang","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.bja.2022.05.007_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1152\/japplphysiol.00096.2016","article-title":"Predicting ventilator-induced lung injury using a lung injury cost function","volume":"121","author":"Hamlington","year":"2016","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.bja.2022.05.007_bib14","first-page":"e0299","article-title":"Atelectrauma versus volutrauma: a tale of two time-constants","volume":"2","author":"Bates","year":"2020","journal-title":"Crit Care Explor"},{"key":"10.1016\/j.bja.2022.05.007_bib15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1164\/rccm.202009-3536OC","article-title":"Effect of lowering Vt on mortality in acute respiratory distress syndrome varies with respiratory system elastance","volume":"203","author":"Goligher","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2022.05.007_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10877-020-00479-x","article-title":"A\u00a0physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection","volume":"35","author":"Zhang","year":"2021","journal-title":"J\u00a0Clin Monit Comput"},{"key":"10.1016\/j.bja.2022.05.007_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13613-021-00935-0","article-title":"Refractory ineffective triggering during pressure support ventilation: effect of proportional assist ventilation with load-adjustable gain factors","volume":"11","author":"Haudebourg","year":"2021","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2022.05.007_bib18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","article-title":"COVID-19 pneumonia: different respiratory treatments for different phenotypes?","volume":"46","author":"Gattinoni","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2022.05.007_bib19","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"COVID-19 Lombardy ICU Network. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2022.05.007_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2022.05.007_bib21","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/ejhf.2058","article-title":"Haemodynamic characteristics of COVID-19 patients with acute respiratory distress syndrome requiring mechanical ventilation. An invasive assessment using right heart catheterization","volume":"22","author":"Caravita","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.bja.2022.05.007_bib22","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/jama.2020.6825","article-title":"Management of COVID-19 respiratory distress","volume":"323","author":"Marini","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2022.05.007_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13054-020-03049-4","article-title":"PEEP levels in COVID-19 pneumonia","volume":"24","author":"Tsolaki","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2022.05.007_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1164\/rccm.202101-0234LE","article-title":"Driving pressure in COVID-19 acute respiratory distress syndrome is associated with respiratory distress duration before intubation","volume":"204","author":"Tsolaki","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2022.05.007_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13054-021-03588-4","article-title":"coVAPid study group. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort","volume":"25","author":"Nseir","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2022.05.007_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13613-016-0131-y","article-title":"Accuracy of delivered airway pressure and work of breathing estimation during proportional assist ventilation: a bench study","volume":"6","author":"Beloncle","year":"2016","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2022.05.007_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13063-019-4035-7","article-title":"Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial","volume":"21","author":"Kim","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.bja.2022.05.007_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13613-020-00725-0","article-title":"Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation","volume":"10","author":"Hurtado","year":"2020","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2022.05.007_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1186\/s13054-014-0505-1","article-title":"Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation","volume":"18","author":"Retamal","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2022.05.007_bib30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s00134-021-06519-7","article-title":"Role of total lung stress on the progression of early COVID-19 pneumonia","volume":"47","author":"Coppola","year":"2021","journal-title":"Intensive Care Med"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091222002458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091222002458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T19:02:54Z","timestamp":1757790174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091222002458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0007091222002458"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2022.05.007","relation":{},"ISSN":["0007-0912"],"issn-type":[{"type":"print","value":"0007-0912"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulation to minimise patient self-inflicted lung injury: are we almost there?","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2022.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2022.02.037","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}