{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:22:04Z","timestamp":1783653724918,"version":"3.55.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["-21-831381-C"],"award-info":[{"award-number":["-21-831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["-21-831376-C"],"award-info":[{"award-number":["-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["-21-831377-C"],"award-info":[{"award-number":["-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["681712"],"award-info":[{"award-number":["681712"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","award":["201809-2016862"],"award-info":[{"award-number":["201809-2016862"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["860197"],"award-info":[{"award-number":["860197"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02532"],"award-info":[{"award-number":["2018-02532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["2017-0243"],"award-info":[{"award-number":["2017-0243"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["-742881"],"award-info":[{"award-number":["-742881"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Familjen Erling-Perssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG063849-01"],"award-info":[{"award-number":["R01 AG063849-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS117901-01"],"award-info":[{"award-number":["1R01NS117901-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["2017-00915"],"award-info":[{"award-number":["2017-00915"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["-201809-2016615"],"award-info":[{"award-number":["-201809-2016615"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bja.2022.10.018","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T19:44:57Z","timestamp":1669319097000},"page":"e361-e369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-4287","authenticated-orcid":false,"given":"Jennifer","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Eisenmenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-4701","authenticated-orcid":false,"given":"Heidi","family":"Lindroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaleena","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-3239","authenticated-orcid":false,"given":"Veena","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1812-8312","authenticated-orcid":false,"given":"David","family":"Kunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-2170","authenticated-orcid":false,"given":"Cameron","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Mrkobrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Devereaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1516-6260","authenticated-orcid":false,"given":"Robert A.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lennertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2022.10.018_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nn.3278","article-title":"The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit","volume":"16","author":"Shih","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bja.2022.10.018_bib2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0140-6736(19)31795-7","article-title":"Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study","volume":"394","author":"Mrkobrada","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2022.10.018_bib3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bja.2020.10.012","article-title":"Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study","volume":"126","author":"Sanders","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.018_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.mayocp.2017.11.021","article-title":"Frequency of acute and subacute infarcts in a population-based study","volume":"93","author":"Arnold Fiebelkorn","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.bja.2022.10.018_bib5","doi-asserted-by":"crossref","first-page":"l4466","DOI":"10.1136\/bmj.l4466","article-title":"Association between major surgical admissions and the cognitive trajectory: 19 year follow-up of Whitehall II cohort study","volume":"366","author":"Krause","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2022.10.018_bib6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.bja.2022.10.018_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ebiom.2015.11.036","article-title":"Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-Sectional study","volume":"3","author":"Gisslen","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bja.2022.10.018_bib8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/gerona\/glab203","article-title":"Cohort analysis of the association of delirium severity with cerebrospinal fluid amyloid-tau-neurodegeneration pathologies","volume":"77","author":"Parker","year":"2022","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.bja.2022.10.018_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/brain\/awz354","article-title":"Postoperative delirium is associated with increased plasma neurofilament light","volume":"143","author":"Casey","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.bja.2022.10.018_bib10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2022.10.018_bib11","doi-asserted-by":"crossref","first-page":"554","DOI":"10.7326\/M14-0865","article-title":"3D-CAM:\u00a0derivation and validation of a 3-minute diagnostic\u00a0interview for CAM-defined delirium: a cross-sectional diagnostic test study","volume":"161","author":"Marcantonio","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bja.2022.10.018_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1176\/jnp.13.2.229","article-title":"Validation of the Delirium Rating Scale-revised-98: comparison with the delirium rating scale and the cognitive test for delirium","volume":"13","author":"Trzepacz","year":"2001","journal-title":"J\u00a0Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.bja.2022.10.018_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-021521","article-title":"Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study","volume":"8","author":"Mrkobrada","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.bja.2022.10.018_bib14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/ana.25889","article-title":"Association of plasma neurofilament light with postoperative delirium","volume":"88","author":"Fong","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bja.2022.10.018_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/ALN.0000000000004327","article-title":"Perioperative neurofilament light plasma concentrations and cognition before and after cardiac surgery: a prospective nested cohort study","volume":"137","author":"Brown","year":"2022","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2022.10.018_bib16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/ALN.0b013e31822e9499","article-title":"Perioperative stroke in noncardiac, nonneurosurgical surgery","volume":"115","author":"Ng","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2022.10.018_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bja.2020.08.061","article-title":"Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study","volume":"126","author":"Ballweg","year":"2021","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122200589X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122200589X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:10:04Z","timestamp":1777378204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709122200589X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S000709122200589X"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2022.10.018","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2022.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}