{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:19:46Z","timestamp":1789823986202,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.bja.2022.10.038","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T15:19:56Z","timestamp":1671031196000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["High-dose dexamethasone in low pain responders undergoing total knee arthroplasty: a randomised double-blind trial"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5172","authenticated-orcid":false,"given":"Niklas I.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Gromov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-8182","authenticated-orcid":false,"given":"Anders","family":"Troelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Husted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-5691","authenticated-orcid":false,"given":"Claus","family":"Varnum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Kj\u00e6rsgaard-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-3193","authenticated-orcid":false,"given":"Lasse E.","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Pleckaitiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai B.","family":"Foss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2022.10.038_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ocl.2017.05.001","article-title":"Perioperative pain management in hip and knee arthroplasty","volume":"48","author":"Gaffney","year":"2017","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.bja.2022.10.038_bib2","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.arth.2021.02.005","article-title":"Factors associated with the risk of developing moderate to severe acute postoperative pain after primary total knee arthroplasty: results from the PAIN OUT registry","volume":"36","author":"Garc\u00eda-L\u00f3pez","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.bja.2022.10.038_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0173107","article-title":"Postoperative pain treatment after total knee arthroplasty: a systematic review","volume":"12","author":"Karlsen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2022.10.038_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/17453674.2019.1683790","article-title":"Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: enhanced Recovery after Surgery (ERAS\u00ae) Society recommendations","volume":"91","author":"Wainwright","year":"2020","journal-title":"Acta Orthop"},{"key":"10.1016\/j.bja.2022.10.038_bib5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/bja\/aeq333","article-title":"Effect of high-dose preoperative methylprednisolone on pain and recovery after total knee arthroplasty: a randomized, placebo-controlled trial","volume":"106","author":"Lunn","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.038_bib6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00167-017-4506-x","article-title":"Two doses of low-dose perioperative dexamethasone improve the clinical outcome after total knee arthroplasty: a randomized controlled study","volume":"26","author":"Xu","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.bja.2022.10.038_bib7","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1016\/j.arth.2018.06.031","article-title":"Multiple doses of perioperative dexamethasone further improve clinical outcomes after total knee arthroplasty: a prospective, randomized, controlled study","volume":"33","author":"Xu","year":"2018","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.bja.2022.10.038_bib8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/anae.14946","article-title":"The systematic review\/meta-analysis epidemic: a tale of glucocorticoid therapy in total knee arthroplasty","volume":"75","author":"Kehlet","year":"2020","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2022.10.038_bib9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.arth.2020.10.010","article-title":"Perioperative systemic dexamethasone reduces length of stay in total joint arthroplasty: a systematic review and meta-analysis of randomized controlled trials","volume":"36","author":"Lex","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.bja.2022.10.038_bib10","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/jama.2012.14144","article-title":"Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial","volume":"308","author":"Dieleman","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2022.10.038_bib11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/ALN.0000000000001466","article-title":"Safety of perioperative glucocorticoids in elective noncardiac surgery: a systematic review and meta-analysis","volume":"126","author":"Toner","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2022.10.038_bib12","first-page":"1","article-title":"Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial","volume":"373","author":"Asehnoune","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2022.10.038_bib13","first-page":"1","article-title":"Current methods and challenges for acute pain clinical trials","volume":"4","author":"Gilron","year":"2019","journal-title":"Pain Rep"},{"key":"10.1016\/j.bja.2022.10.038_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.amjsurg.2010.02.007","article-title":"Catastrophizing: a predictive factor for postoperative pain","volume":"201","author":"Khan","year":"2011","journal-title":"Am J Surg"},{"key":"10.1016\/j.bja.2022.10.038_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/aas.12667","article-title":"Chronic pre-operative opioid use and acute pain after fast-track total knee arthroplasty","volume":"60","author":"Aasvang","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2022.10.038_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bja.2021.10.001","article-title":"High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial","volume":"128","author":"Nielsen","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.038_bib17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The pain catastrophizing scale: development and validation","volume":"7","author":"Sullivan","year":"1995","journal-title":"Psychol Assess"},{"key":"10.1016\/j.bja.2022.10.038_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/17453674.2012.700593","article-title":"Fast-track hip and knee arthroplasty: clinical and organizational aspects","volume":"83","author":"Husted","year":"2012","journal-title":"Acta Orthop"},{"key":"10.1016\/j.bja.2022.10.038_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bja.2017.11.013","article-title":"Systematic review of the QoR-15 score, a patient-reported outcome measure measuring quality of recovery after surgery and anaesthesia","volume":"120","author":"Kleif","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.038_bib20","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s11136-009-9547-2","article-title":"Development and validation of a composite score based on clinically meaningful events for the opioid-related symptom distress scale","volume":"18","author":"Chan","year":"2009","journal-title":"Qual Life Res"},{"key":"10.1016\/j.bja.2022.10.038_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 subjects and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.bja.2022.10.038_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00008483-200207000-00014","article-title":"Criterion validity of the Duke Activity Status Index for assessing functional capacity in subjects with chronic obstructive pulmonary disease","volume":"22","author":"Carter","year":"2002","journal-title":"J\u00a0Cardiopulm Rehabil"},{"key":"10.1016\/j.bja.2022.10.038_bib23","first-page":"1","article-title":"Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial","volume":"376","author":"Gasbjerg","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2022.10.038_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/bja\/aex190","article-title":"Safety aspects of preoperative high-dose glucocorticoid in primary total knee replacement","volume":"119","author":"J\u00f8rgensen","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.038_bib25","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1016\/j.arth.2021.03.057","article-title":"Postoperative infection risk in total joint arthroplasty after perioperative IV corticosteroid administration: a systematic review and meta-analysis of comparative studies","volume":"36","author":"Feeley","year":"2021","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.bja.2022.10.038_bib26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/aas.12932","article-title":"Delirium after fast-track hip and knee arthroplasty \u2013 a cohort study of 6331 elderly subjects","volume":"61","author":"Petersen","year":"2017","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2022.10.038_bib27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/anae.14406","article-title":"Effect of a single pre-operative 125 mg dose\u00a0of\u00a0methylprednisolone on postoperative delirium\u00a0in\u00a0hip\u00a0fracture subjects; a randomised, double-blind, placebo-controlled trial","volume":"73","author":"Clemmesen","year":"2018","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2022.10.038_bib28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/anae.15465","article-title":"Steroids to reduce the impact on delirium (STRIDE): a double-blind, randomised, placebo-controlled feasibility trial of pre-operative dexamethasone in people with hip fracture","volume":"76","author":"Kluger","year":"2021","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2022.10.038_bib29","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1213\/ANE.0000000000000248","article-title":"Intraoperative dexamethasone and delirium after cardiac surgery","volume":"119","author":"Sau\u00ebr","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2022.10.038_bib30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bja.2022.04.019","article-title":"Critical appraisal of randomised trials assessing regional analgesic interventions for knee arthroplasty: implications for postoperative pain guidelines development","volume":"129","author":"Joshi","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2022.10.038_bib31","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/aas.13656","article-title":"Preoperative high-dose steroids in total knee and hip arthroplasty \u2013 protocols for three randomized controlled trials","volume":"64","author":"Nielsen","year":"2020","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091222006304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091222006304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T19:05:13Z","timestamp":1757790313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091222006304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0007091222006304"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2022.10.038","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-dose dexamethasone in low pain responders undergoing total knee arthroplasty: a randomised double-blind trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2022.10.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}