{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:07:14Z","timestamp":1793362034051,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.15175"],"award-info":[{"award-number":["320.6750.15175"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC2001800"],"award-info":[{"award-number":["2018YFC2001800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bja.2023.01.023","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T20:05:25Z","timestamp":1685822725000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial"],"prefix":"10.1016","volume":"131","author":[{"given":"Shuang-Jie","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-De","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Shan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Qing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Qiu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Jiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Heng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-3399","authenticated-orcid":false,"given":"Ning","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Sessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-1836","authenticated-orcid":false,"given":"Dong-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2023.01.023_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bja.2023.01.023_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrclinonc.2014.224","article-title":"Exploiting the critical perioperative period to improve long-term cancer outcomes","volume":"12","author":"Horowitz","year":"2015","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.bja.2023.01.023_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccell.2017.06.009","article-title":"Control of metastasis by NK cells","volume":"32","author":"Lopez-Soto","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bja.2023.01.023_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-018-1389-7","article-title":"Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence","volume":"16","author":"Kim","year":"2018","journal-title":"J Transl Med"},{"key":"10.1016\/j.bja.2023.01.023_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxlet.2016.12.007","article-title":"The effect of different anesthetics on tumor cytotoxicity by natural killer cells","volume":"266","author":"Tazawa","year":"2017","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bja.2023.01.023_bib6","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1213\/01.ANE.0000082995.44040.07","article-title":"Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures","volume":"97","author":"Melamed","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2023.01.023_bib7","doi-asserted-by":"crossref","first-page":"i56","DOI":"10.1093\/bja\/aeu200","article-title":"Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study","volume":"113","author":"Buckley","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.01.023_bib8","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3390\/ijms22041826","article-title":"Sevoflurane and desflurane exposure enhanced cell proliferation and migration in ovarian cancer cells via miR-210 and miR-138 downregulation","volume":"22","author":"Ishikawa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bja.2023.01.023_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/ALN.0b013e31829e47fd","article-title":"Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro","volume":"119","author":"Benzonana","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib10","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/bjc.2014.426","article-title":"Prostate cancer cell malignancy via modulation of HIF-1\u03b1 pathway with isoflurane and propofol alone and in combination","volume":"111","author":"Huang","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bja.2023.01.023_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2020.12.007","article-title":"Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: implication of reducing cancer recurrence risk","volume":"31","author":"Hu","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.bja.2023.01.023_bib12","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/aas.13644","article-title":"Survival after primary breast cancer surgery following propofol or sevoflurane general anesthesia\u2014a retrospective, multicenter, database analysis of 6305 Swedish patients","volume":"64","author":"Enlund","year":"2020","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2023.01.023_bib13","doi-asserted-by":"crossref","first-page":"14020","DOI":"10.1038\/s41598-017-14147-9","article-title":"Impact of anesthetic agents on overall and recurrence-free survival in patients undergoing esophageal cancer surgery: a retrospective observational study","volume":"7","author":"Jun","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bja.2023.01.023_bib14","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2147\/OTT.S156792","article-title":"Effects of propofol-based total intravenous anesthesia on gastric cancer: a retrospective study","volume":"11","author":"Zheng","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.bja.2023.01.023_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bja.2019.04.057","article-title":"Propofol-based total intravenous anaesthesia is associated with better survival than desflurane anaesthesia in hepatectomy for hepatocellular carcinoma: a retrospective cohort study","volume":"123","author":"Lai","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.01.023_bib16","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000018472","article-title":"Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in intrahepatic cholangiocarcinoma surgery","volume":"98","author":"Lai","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bja.2023.01.023_bib17","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/ALN.0000000000002357","article-title":"Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery","volume":"129","author":"Wu","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/ALN.0000000000000936","article-title":"Long-term survival for patients undergoing volatile versus iv anesthesia for cancer surgery: a retrospective analysis","volume":"124","author":"Wigmore","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/ANA.0000000000000588","article-title":"Impact of anesthesia on long-term outcomes in patients with supratentorial high-grade glioma undergoing tumor resection: a retrospective cohort study","volume":"32","author":"Dong","year":"2020","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1016\/j.bja.2023.01.023_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/ALN.0000000000002491","article-title":"Total intravenous anesthesia\u00a0versus inhalation anesthesia for breast cancer surgery: a retrospective cohort study","volume":"130","author":"Yoo","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224728","article-title":"Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery","volume":"14","author":"Huang","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2023.01.023_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/1073274818775360","article-title":"Long-term oncologic outcomes for patients undergoing volatile versus intravenous anesthesia for non-small cell lung cancer surgery: a retrospective propensity matching analysis","volume":"25","author":"Oh","year":"2018","journal-title":"Cancer Control"},{"key":"10.1016\/j.bja.2023.01.023_bib23","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/aas.13414","article-title":"Retrospective analysis of 1-year mortality after gastric cancer surgery: total intravenous anesthesia versus volatile anesthesia","volume":"63","author":"Oh","year":"2019","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2023.01.023_bib24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bja.2020.11.019","article-title":"Inhalation or total intravenous anaesthesia and recurrence after colorectal cancer surgery: a propensity score matched Danish registry-based study","volume":"126","author":"Hasselager","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.01.023_bib25","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/ALN.0000000000003440","article-title":"Volatile versus total intravenous anesthesia for cancer prognosis in patients having digestive cancer surgery","volume":"133","author":"Makito","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/03009734.2014.922649","article-title":"The choice of anaesthetic\u2014sevoflurane or propofol\u2014and outcome from cancer surgery: a retrospective analysis","volume":"119","author":"Enlund","year":"2014","journal-title":"Ups J Med Sci"},{"key":"10.1016\/j.bja.2023.01.023_bib27","doi-asserted-by":"crossref","first-page":"d1491","DOI":"10.1136\/bmj.d1491","article-title":"Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial","volume":"342","author":"Myles","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2023.01.023_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/ALN.0000000000003835","article-title":"Long-term survival after combined epidural\u2013general anesthesia or general anesthesia alone: follow-up of a randomized trial","volume":"135","author":"Du","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018607","article-title":"Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial","volume":"7","author":"Zhang","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.bja.2023.01.023_bib30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bja.2018.05.059","article-title":"Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults","volume":"121","author":"Zhang","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.01.023_bib31","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/aas.13116","article-title":"Preoperative vitamin D deficiency increases the risk of postoperative cognitive dysfunction: a predefined exploratory sub-analysis","volume":"62","author":"Zhang","year":"2018","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2023.01.023_bib32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/ALN.0000000000002323","article-title":"Processed electroencephalogram monitoring and postoperative delirium: a systematic review and meta-analysis","volume":"129","author":"MacKenzie","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.01.023_bib33","series-title":"AJCC Cancer Staging Manual","year":"2017"},{"key":"10.1016\/j.bja.2023.01.023_bib34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bja.2023.01.023_bib35","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.ejca.2008.05.008","article-title":"Quality, interpretation and presentation of European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30 data in randomised controlled trials","volume":"44","author":"Cocks","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.bja.2023.01.023_bib36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/SLA.0000000000002801","article-title":"Impact of dexmedetomidine on long-term outcomes after noncardiac surgery in elderly: 3-year follow-up of a randomized controlled trial","volume":"270","author":"Zhang","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.bja.2023.01.023_bib37","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"key":"10.1016\/j.bja.2023.01.023_bib38","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2020.0431","article-title":"Association of preoperative patient frailty and operative stress with postoperative mortality","volume":"155","author":"Shinall","year":"2020","journal-title":"JAMA Surg"},{"key":"10.1016\/j.bja.2023.01.023_bib39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrc1886","article-title":"Metastasis: a question of life or death","volume":"6","author":"Mehlen","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bja.2023.01.023_bib40","article-title":"Anesthetic propofol promotes tumor metastasis in lungs via GABAA R-dependent TRIM21 modulation of Src expression","volume":"8","author":"Liu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bja.2023.01.023_bib41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.4149\/neo_2018_181213N962","article-title":"Sevoflurane inhibits migration and invasion of colorectal cancer cells by regulating microRNA-34a\/ADAM10 axis","volume":"66","author":"Sun","year":"2019","journal-title":"Neoplasma"},{"key":"10.1016\/j.bja.2023.01.023_bib42","doi-asserted-by":"crossref","first-page":"117897","DOI":"10.1016\/j.lfs.2020.117897","article-title":"Sevoflurane inhibits migration and invasion of glioma cells via regulating miR-34a-5p\/MMP-2 axis","volume":"256","author":"Zhao","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.bja.2023.01.023_bib43","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/anae.15354","article-title":"Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large randomised control trial","volume":"76","author":"Dubowitz","year":"2021","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2023.01.023_bib44","article-title":"Propofol versus sevoflurane anaesthesia on delirium in older patients after cancer surgery: a multicentre randomized trial","author":"Cao","year":"2021","journal-title":"Br J Anaesth under review"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091223000326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091223000326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:10:15Z","timestamp":1777378215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091223000326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0007091223000326"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2023.01.023","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2023.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}