{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:32:56Z","timestamp":1790346776849,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03-AG067976"],"award-info":[{"award-number":["R03-AG067976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005831","name":"Foundation for Anesthesia Education and Research","doi-asserted-by":"publisher","award":["K76-AG057022"],"award-info":[{"award-number":["K76-AG057022"]}],"id":[{"id":"10.13039\/100005831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bja.2023.05.009","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T01:52:56Z","timestamp":1686880376000},"page":"205-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-1094","authenticated-orcid":false,"given":"Tyler H.","family":"Reekes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Devinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2386-5061","authenticated-orcid":false,"given":"Miles","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2023.05.009_bib1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S1474-4422(15)00101-5","article-title":"The interface between delirium and dementia in elderly adults","volume":"14","author":"Fong","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bja.2023.01.020","article-title":"Prospective analysis of plasma amyloid beta and postoperative delirium in the Interventions for Postoperative Delirium: biomarker-3 study","volume":"130","author":"Payne","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.05.009_bib3","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.bja.2023.05.009_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J\u00a0Geriatr Psychiatry Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/35050103","article-title":"A\u00a0learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer\u2019s disease","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bja.2023.05.009_bib7","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1016\/j.neurobiolaging.2015.08.023","article-title":"Altered hippocampal information coding and network synchrony in APP-PS1 mice","volume":"36","author":"Cayzac","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bja.2023.05.009_bib8","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1523\/JNEUROSCI.2009-15.2015","article-title":"The APP intracellular domain is required for normal synaptic morphology, synaptic plasticity, and hippocampus-dependent behavior","volume":"35","author":"Klevanski","year":"2015","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.bja.2023.05.009_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fnins.2020.00266","article-title":"Hippocampal deficits in amyloid-beta-related rodent models of Alzheimer\u2019s disease","volume":"14","author":"Vyas","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.bja.2023.05.009_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3233\/JAD-142208","article-title":"Systematic review of the relationship between amyloid-beta levels and measures of transgenic mouse cognitive deficit in Alzheimer\u2019s disease","volume":"44","author":"Foley","year":"2015","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.bja.2023.05.009_bib11","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2023.05.009_bib13","doi-asserted-by":"crossref","first-page":"n1682","DOI":"10.1136\/bmj.n1682","article-title":"Aducanumab for Alzheimer\u2019s disease?","volume":"374","author":"Walsh","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2023.05.009_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2017.08.010","article-title":"Anti-amyloid-beta monoclonal antibodies for Alzheimer\u2019s disease: pitfalls and promise","volume":"83","author":"van Dyck","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bja.2023.05.009_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13195-019-0485-0","article-title":"Advantages and disadvantages of the use of the CSF amyloid \u03b2 (A\u03b2) 42\/40 ratio in the diagnosis of Alzheimer\u2019s disease","volume":"11","author":"Hansson","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.bja.2023.05.009_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/acn3.51499","article-title":"Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers","volume":"9","author":"Berger","year":"2022","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/ALN.0b013e31822e9306","article-title":"Human Alzheimer and inflammation biomarkers after anesthesia and surgery","volume":"115","author":"Tang","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.05.009_bib18","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/ALN.0000000000002103","article-title":"18F-florbetapir positron emission tomography-determined cerebral \u03b2-amyloid deposition and neurocognitive performance after cardiac surgery","volume":"128","author":"Klinger","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.05.009_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bja.2022.01.005","article-title":"Postoperative delirium and changes in the blood\u2013brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study","volume":"129","author":"Taylor","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.05.009_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3233\/JAD-2011-101977","article-title":"Meta-analysis of plasma amyloid-\u03b2 levels in Alzheimer\u2019s disease","volume":"26","author":"Song","year":"2011","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.bja.2023.05.009_bib21","article-title":"Conserved YKL-40 changes in mice and humans after postoperative delirium","volume":"26","author":"David-Bercholz","year":"2022","journal-title":"Brain Behav Immun Health"},{"key":"10.1016\/j.bja.2023.05.009_bib22","doi-asserted-by":"crossref","unstructured":"Devinney MJ, Wong MK, Wright MC, et\u00a0al. A role for blood-brain barrier dysfunction in delirium following non-cardiac surgery in older adults. medRxiv Preprint published on May 10, doi: https:\/\/doi.org\/10.1101\/2023.04.07.23288303.","DOI":"10.1101\/2023.04.07.23288303"},{"key":"10.1016\/j.bja.2023.05.009_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/acn3.58","article-title":"Preoperative cerebrospinal fluid \u03b2-amyloid\/tau ratio and postoperative delirium","volume":"1","author":"Xie","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.bja.2023.05.009_bib24","article-title":"Association of CSF Alzheimer\u2019s disease biomarkers with postoperative delirium in older adults","volume":"7","author":"Fong","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.bja.2023.05.009_bib25","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/SLA.0000000000002684","article-title":"CSF beta-amyloid 1\u201342 concentration predicts delirium following elective arthroplasty surgery in an observational cohort study","volume":"269","author":"Cunningham","year":"2019","journal-title":"Ann Surg"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091223002453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091223002453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T19:05:32Z","timestamp":1757790332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091223002453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0007091223002453"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2023.05.009","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2023.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2023.01.020","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}