{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:59:05Z","timestamp":1787504345255,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171210"],"award-info":[{"award-number":["82171210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-BHX0015"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0015"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTC2021JCYJ-MSXMX0188"],"award-info":[{"award-number":["CSTC2021JCYJ-MSXMX0188"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bja.2023.08.039","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:36:47Z","timestamp":1696865807000},"page":"1072-1081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-0304","authenticated-orcid":false,"given":"Bin","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9200-6773","authenticated-orcid":false,"given":"Huiting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2917-8810","authenticated-orcid":false,"given":"Xuemei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3141-5239","authenticated-orcid":false,"given":"Yuanjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-1201","authenticated-orcid":false,"given":"Hongni","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-7882","authenticated-orcid":false,"given":"Guangyou","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2023.08.039_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/healthcare9030333","article-title":"Perioperative pain management and opioid stewardship: a practical guide","volume":"9","author":"Hyland","year":"2021","journal-title":"Healthcare"},{"key":"10.1016\/j.bja.2023.08.039_bib2","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1097\/MJT.0000000000000019","article-title":"Remifentanil-acute opioid tolerance and opioid-induced hyperalgesia: a systematic review","volume":"22","author":"Kim","year":"2015","journal-title":"Am J Ther"},{"key":"10.1016\/j.bja.2023.08.039_bib3","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1097\/MJT.0000000000000734","article-title":"Opioid-induced hyperalgesia in the nonsurgical setting: a systematic review","volume":"26","author":"Yang","year":"2019","journal-title":"Am J Ther"},{"key":"10.1016\/j.bja.2023.08.039_bib4","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/00000542-199511000-00009","article-title":"Measured context-sensitive half-times of remifentanil and alfentanil","volume":"83","author":"Kapila","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.08.039_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/j.pain.0000000000001713","article-title":"Remifentanil for abdominal surgery is associated with unexpectedly unfavorable outcomes","volume":"161","author":"Niedermayer","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.08.039_bib6","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/anae.13602","article-title":"Remifentanil tolerance and hyperalgesia: short-term gain, long-term pain?","volume":"71","author":"Yu","year":"2016","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2023.08.039_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00000542-200507000-00022","article-title":"Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine","volume":"103","author":"Joly","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.08.039_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/aas.13470","article-title":"Low- versus high-dose intraoperative opioids: a systematic review with meta-analyses and trial sequential analyses","volume":"64","author":"Albrecht","year":"2020","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.bja.2023.08.039_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/ALN.0000000000000976","article-title":"Does fentanyl lead to opioid-induced hyperalgesia in healthy volunteers?: a double-blind, randomized, crossover trial","volume":"124","author":"Mauermann","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.08.039_bib10","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S0140-6736(19)30430-1","article-title":"Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia","volume":"393","author":"Colvin","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2023.08.039_bib11","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0140-6736(19)30352-6","article-title":"Transition from acute to chronic pain after surgery","volume":"393","author":"Glare","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2023.08.039_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neures.2018.07.007","article-title":"Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12\/CXCR4 in rats","volume":"144","author":"Li","year":"2019","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bja.2023.08.039_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/ALN.0b013e31817f4c5d","article-title":"Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance","volume":"109","author":"Zhao","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2023.08.039_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/AJP.0b013e31816b2f43","article-title":"Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations","volume":"24","author":"Chu","year":"2008","journal-title":"Clin J Pain"},{"key":"10.1016\/j.bja.2023.08.039_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2217\/pmt-2020-0105","article-title":"Mechanisms, diagnosis, prevention and management of perioperative opioid-induced hyperalgesia","volume":"11","author":"Wilson","year":"2021","journal-title":"Pain Manag"},{"key":"10.1016\/j.bja.2023.08.039_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pain.2005.04.014","article-title":"Role of NK-1 neurotransmission in opioid-induced hyperalgesia","volume":"116","author":"King","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.08.039_bib17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.brainresbull.2021.10.006","article-title":"P2Y1 purinergic receptor inhibition attenuated remifentanil-induced postoperative hyperalgesia via decreasing NMDA receptor phosphorylation in dorsal root ganglion","volume":"177","author":"Su","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.bja.2023.08.039_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainresbull.2014.12.001","article-title":"Inhibition of DOR prevents remifentanil induced postoperative hyperalgesia through regulating the trafficking and function of spinal NMDA receptors in\u00a0vivo and in\u00a0vitro","volume":"110","author":"Wang","year":"2015","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.bja.2023.08.039_bib19","first-page":"667","article-title":"TRPV1 channel contributes to remifentanil-induced postoperative hyperalgesia via regulation of NMDA receptor trafficking in dorsal root ganglion","volume":"12","author":"Song","year":"2019","journal-title":"J\u00a0Pain Res"},{"key":"10.1016\/j.bja.2023.08.039_bib20","first-page":"653","article-title":"The efficacy of NMDA receptor antagonists for preventing remifentanil-induced increase in postoperative pain and analgesic requirement: a meta-analysis","volume":"78","author":"Liu","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.bja.2023.08.039_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jclinane.2015.03.020","article-title":"The efficacy of N-methyl-D-aspartate receptor antagonists on improving the postoperative pain intensity and satisfaction after remifentanil-based anesthesia in adults: a meta-analysis","volume":"27","author":"Wu","year":"2015","journal-title":"J\u00a0Clin Anesth"},{"key":"10.1016\/j.bja.2023.08.039_bib22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.cbi.2019.05.049","article-title":"Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice","volume":"308","author":"Lin","year":"2019","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bja.2023.08.039_bib23","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.7150\/thno.28676","article-title":"Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bja.2023.08.039_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.bja.2023.08.039_bib25","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s12264-020-00568-6","article-title":"Spinal cord stimulation enhances microglial activation in the spinal cord of nerve-injured rats","volume":"36","author":"Shu","year":"2020","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.bja.2023.08.039_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bja.2023.08.039_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb0738","article-title":"Clocks, cancer, and chronochemotherapy","volume":"371","author":"Sancar","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.bja.2023.08.039_bib28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neubiorev.2021.08.004","article-title":"Circadian rhythms and pain","volume":"129","author":"Bumgarner","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bja.2023.08.039_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0163-7258(95)02003-9","article-title":"Biological rhythms in pain and in the effects of opioid analgesics","volume":"68","author":"Labrecque","year":"1995","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bja.2023.08.039_bib30","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1007\/s12035-019-01650-5","article-title":"Opioid-induced hyperalgesia is associated with dysregulation of circadian rhythm and adaptive immune pathways in the mouse trigeminal ganglia and nucleus accumbens","volume":"56","author":"Zhang","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.bja.2023.08.039_bib31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.toxlet.2010.03.020","article-title":"The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver","volume":"196","author":"Qu","year":"2010","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bja.2023.08.039_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bja.2017.11.103","article-title":"Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats","volume":"120","author":"Li","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.08.039_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.semcdb.2021.04.010","article-title":"Estrogens and the circadian system","volume":"126","author":"Alvord","year":"2022","journal-title":"Semin Cell Dev Biol"},{"issue":"Suppl 1","key":"10.1016\/j.bja.2023.08.039_bib34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.pain.2007.09.028","article-title":"Modulation of pain by estrogens","volume":"132","author":"Craft","year":"2007","journal-title":"Pain"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122300497X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122300497X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T19:07:52Z","timestamp":1757790472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709122300497X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S000709122300497X"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2023.08.039","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opioid infusions at different times of the day produce varying degrees of opioid-induced hyperalgesia","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2023.08.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}