{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:31:36Z","timestamp":1793367096642,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790624"],"award-info":[{"award-number":["81790624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91839302"],"award-info":[{"award-number":["91839302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017SHZDZX01"],"award-info":[{"award-number":["2017SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ202201016"],"award-info":[{"award-number":["YCJJ202201016"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bja.2023.11.007","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T12:56:54Z","timestamp":1702645014000},"page":"372-382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Genetic insights into associations of multisite chronic pain with common diseases and biomarkers using data from the UK Biobank"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-7868","authenticated-orcid":false,"given":"Yanghui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-4366","authenticated-orcid":false,"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0512-785X","authenticated-orcid":false,"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-3980","authenticated-orcid":false,"given":"Dao Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2023.11.007_bib1","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","article-title":"Chronic pain: an update on burden, best practices, and new advances","volume":"397","author":"Cohen","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2023.11.007_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.46697","article-title":"Prevalence of pain management techniques among adults with chronic pain in the United States, 2019","volume":"5","author":"Groenewald","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bja.2023.11.007_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.bja.2023.11.007_bib4","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1097\/j.pain.0000000000002291","article-title":"Prevalence of chronic pain among adults in the United States","volume":"163","author":"Yong","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib5","doi-asserted-by":"crossref","first-page":"e884","DOI":"10.1097\/PR9.0000000000000884","article-title":"Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic","volume":"6","author":"Attal","year":"2021","journal-title":"Pain Rep"},{"key":"10.1016\/j.bja.2023.11.007_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bja.2023.04.020","article-title":"Genetic liability to multi-site chronic pain increases the risk of cardiovascular disease","volume":"131","author":"Lin","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.11.007_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"issue":"Suppl 1","key":"10.1016\/j.bja.2023.11.007_bib8","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1097\/j.pain.0000000000001296","article-title":"Chronic pain and mental health: integrated solutions for global problems","volume":"159","author":"Kohrt","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.mayocp.2016.04.029","article-title":"Chronic pain and mental health disorders: shared neural mechanisms, epidemiology, and treatment","volume":"91","author":"Hooten","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.bja.2023.11.007_bib10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S1699-258X(05)72745-5","article-title":"Is there an association between fibromyalgia and an increase in comorbidity: neoplastic and cardiovascular diseases, infections and mortality?","volume":"1","author":"Chamizo-Carmona","year":"2005","journal-title":"Reumatol Clin"},{"key":"10.1016\/j.bja.2023.11.007_bib11","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/eurheartj\/ehz111","article-title":"Widespread pain is a risk factor for cardiovascular mortality: results from the Framingham Heart Study","volume":"40","author":"Tesarz","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bja.2023.11.007_bib12","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/eurjpc\/zwac127","article-title":"The association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease in the UK Biobank","volume":"29","author":"Ronnegard","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.bja.2023.11.007_bib13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.sjpain.2016.06.005","article-title":"Assessing the relationship between chronic pain and cardiovascular disease: a systematic review and meta-analysis","volume":"13","author":"Fayaz","year":"2016","journal-title":"Scand J Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","article-title":"Advances and challenges in neuropathic pain: a narrative review and future directions","volume":"131","author":"Attal","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2023.11.007_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/WCO.0000000000000980","article-title":"Advances in the treatment of neuropathic pain","volume":"34","author":"Attal","year":"2021","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.bja.2023.11.007_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101971","article-title":"Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study","volume":"59","author":"Faber","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.bja.2023.11.007_bib17","first-page":"93","article-title":"WHO guidelines for the use of analgesics in cancer pain","volume":"7","author":"Ventafridda","year":"1985","journal-title":"Int J Tissue React"},{"key":"10.1016\/j.bja.2023.11.007_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bja.2023.11.007_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00296-016-3481-8","article-title":"An overview of treatment approaches for chronic pain management","volume":"37","author":"Hylands-White","year":"2017","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.bja.2023.11.007_bib20","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1093\/eurheartj\/ehab170","article-title":"Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank","volume":"42","author":"Ai","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bja.2023.11.007_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003553","article-title":"Cardiometabolic risk factors for COVID-19 susceptibility and severity: a Mendelian randomization analysis","volume":"18","author":"Leong","year":"2021","journal-title":"PLoS Med"},{"key":"10.1016\/j.bja.2023.11.007_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103948","article-title":"Association between plasma proteome and childhood neurodevelopmental disorders: a two-sample Mendelian randomization analysis","volume":"78","author":"Yang","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bja.2023.11.007_bib23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/CIRCULATIONAHA.121.056663","article-title":"Therapeutic targets for heart failure identified using proteomics and mendelian randomization","volume":"145","author":"Henry","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2023.11.007_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104199","article-title":"Genetic insights into therapeutic targets for aortic aneurysms: a Mendelian randomization study","volume":"83","author":"Chen","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bja.2023.11.007_bib25","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1161\/CIRCULATIONAHA.119.040180","article-title":"Novel drug targets for ischemic stroke identified through mendelian randomization analysis of the blood proteome","volume":"140","author":"Chong","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2023.11.007_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104488","article-title":"Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases","volume":"89","author":"Yuan","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bja.2023.11.007_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009428","article-title":"Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank","volume":"17","author":"Johnston","year":"2021","journal-title":"PLoS Genet"},{"key":"10.1016\/j.bja.2023.11.007_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.bja.2023.11.007_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.bja.2023.11.007_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.bja.2023.11.007_bib31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.bja.2023.11.007_bib32","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.bja.2023.11.007_bib33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/AJP.0000000000000536","article-title":"The relationship between chronic pain and neurocognitive function: a systematic review","volume":"34","author":"Higgins","year":"2018","journal-title":"Clin J Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tics.2021.01.001","article-title":"Cognition in the chronic pain experience: preclinical insights","volume":"25","author":"Phelps","year":"2021","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.bja.2023.11.007_bib35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pain.2004.11.010","article-title":"Chronic spinal pain and physical-mental comorbidity in the United States: results from the national comorbidity survey replication","volume":"113","author":"Von Korff","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pain.2003.09.015","article-title":"Chronic back pain and major depression in the general Canadian population","volume":"107","author":"Currie","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib37","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1017\/S0033291705004952","article-title":"More data on major depression as an antecedent risk factor for first onset of chronic back pain","volume":"35","author":"Currie","year":"2005","journal-title":"Psychol Med"},{"key":"10.1016\/j.bja.2023.11.007_bib38","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1097\/j.pain.0000000000002732","article-title":"Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization","volume":"164","author":"Zhu","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.7150\/thno.22414","article-title":"Targeting ALDH2 for therapeutic interventions in chronic pain-related myocardial ischemic susceptibility","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bja.2023.11.007_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yjmcc.2018.10.018","article-title":"Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL\/CaMKII dependent necroptosis","volume":"125","author":"Yang","year":"2018","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.bja.2023.11.007_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107581","article-title":"Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential","volume":"212","author":"Jiang","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bja.2023.11.007_bib42","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pain.2009.11.017","article-title":"The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition","volume":"148","author":"Gao","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib43","first-page":"485","article-title":"Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury","volume":"13","author":"Kanngiesser","year":"2012","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.bja.2023.11.007_bib44","first-page":"685","article-title":"Promoted interaction of C\/EBP\u03b1 with demethylated Cxcr3 gene promoter contributes to neuropathic pain in mice","volume":"37","author":"Jiang","year":"2017","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.bja.2023.11.007_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41573-022-00561-w","article-title":"Using human genetics to improve safety assessment of therapeutics","volume":"22","author":"Carss","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bja.2023.11.007_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.5603\/AIT.2013.0040","article-title":"Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain?","volume":"45","author":"Paparella","year":"2013","journal-title":"Anaesthesiol Intensive Ther"},{"key":"10.1016\/j.bja.2023.11.007_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13018-017-0526-y","article-title":"Effect of oxidative stress induced by intracranial iron overload on central pain after spinal cord injury","volume":"12","author":"Meng","year":"2017","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.bja.2023.11.007_bib48","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00018-017-2526-9","article-title":"S100A6 protein: functional roles","volume":"74","author":"Donato","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.bja.2023.11.007_bib49","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2353\/ajpath.2010.091217","article-title":"S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer","volume":"177","author":"Wang","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bja.2023.11.007_bib50","first-page":"1291","article-title":"Expression of calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice","volume":"52","author":"Weterman","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.bja.2023.11.007_bib51","doi-asserted-by":"crossref","first-page":"31317","DOI":"10.1074\/jbc.M703951200","article-title":"S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains","volume":"282","author":"Leclerc","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2023.11.007_bib52","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1046\/j.1471-4159.1998.70051793.x","article-title":"Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin","volume":"70","author":"Filipek","year":"1998","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.bja.2023.11.007_bib53","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.freeradbiomed.2011.01.026","article-title":"Roles of reactive oxygen and nitrogen species in pain","volume":"51","author":"Salvemini","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bja.2023.11.007_bib54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.redox.2017.10.011","article-title":"Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain","volume":"14","author":"Zhou","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/j.bja.2023.11.007_bib55","doi-asserted-by":"crossref","first-page":"23895","DOI":"10.1074\/jbc.M116.728550","article-title":"The protein tyrosine phosphatase MEG2 regulates the transport and signal transduction of tropomyosin receptor kinase A","volume":"291","author":"Zhang","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2023.11.007_bib56","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1084\/jem.20051108","article-title":"Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function","volume":"202","author":"Wang","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.bja.2023.11.007_bib57","doi-asserted-by":"crossref","first-page":"14861","DOI":"10.1074\/jbc.M109.099879","article-title":"Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells","volume":"285","author":"Yuan","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.bja.2023.11.007_bib58","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cmet.2006.03.006","article-title":"Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling","volume":"3","author":"Cho","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.bja.2023.11.007_bib59","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122300627X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122300627X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T19:08:27Z","timestamp":1757790507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709122300627X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S000709122300627X"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2023.11.007","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic insights into associations of multisite chronic pain with common diseases and biomarkers using data from the UK Biobank","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2023.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}