{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:47:28Z","timestamp":1770774448310,"version":"3.50.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AG070371"],"award-info":[{"award-number":["R21 AG070371"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL-051952"],"award-info":[{"award-number":["HL-051952"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004333","name":"La Jolla Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bja.2024.04.061","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T07:27:19Z","timestamp":1718954839000},"page":"667-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Angiotensin II treatment of hypotension in noncardiac surgery: an initial dose-finding study"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-3291","authenticated-orcid":false,"given":"Rohesh J.","family":"Fernando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger L.","family":"Royster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-6239","authenticated-orcid":false,"given":"Carlos M.","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-4319","authenticated-orcid":false,"given":"Amit K.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-1618","authenticated-orcid":false,"given":"Sarfaraz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-9915","authenticated-orcid":false,"given":"Daryl S.","family":"Henshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-5279","authenticated-orcid":false,"given":"Sarah L.","family":"Kittner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6431-3908","authenticated-orcid":false,"given":"Ashley L.","family":"Talbott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-891X","authenticated-orcid":false,"given":"Ashish K.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin N.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-7358","authenticated-orcid":false,"given":"Leanne","family":"Groban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-8138","authenticated-orcid":false,"given":"Thomas W.","family":"Templeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2024.04.061_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s13054-014-0534-9","article-title":"Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study","volume":"18","author":"Chawla","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2024.04.061_bib2","doi-asserted-by":"crossref","first-page":"H137","DOI":"10.1152\/ajpheart.00618.2015","article-title":"Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?","volume":"310","author":"Chappell","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bja.2024.04.061_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bja.2022.07.056","article-title":"Endotypes\u00a0of intraoperative hypotension during major abdominal surgery: a retrospective machine learning analysis of an observational cohort study","volume":"130","author":"Kouz","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.04.061_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the treatment of vasodilatory shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bja.2024.04.061_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.jvca.2020.08.001","article-title":"Treatment with\u00a0angiotensin II is associated with rapid blood pressure\u00a0response and vasopressor sparing in patients\u00a0with vasoplegia after cardiac surgery: a post-hoc analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study","volume":"35","author":"Klijian","year":"2021","journal-title":"J\u00a0Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2024.04.061_bib6","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jtcvs.2021.02.097","article-title":"Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients","volume":"163","author":"Chow","year":"2022","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bja.2024.04.061_bib7","unstructured":"Giapreza (Angiotensin II) [package insert]. U.S Food Drug Adm Website. Available from https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/209360s000lbl.pdf (accessed 24 July 2022)."},{"key":"10.1016\/j.bja.2024.04.061_bib8","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1053\/j.jvca.2019.03.004","article-title":"Synthetic human angiotensin II for postcardiopulmonary bypass vasoplegic shock","volume":"33","author":"Wieruszewski","year":"2019","journal-title":"J\u00a0Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2024.04.061_bib9","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1053\/j.jvca.2020.07.087","article-title":"Angiotensin II for critically ill patients with shock after heart transplant","volume":"35","author":"Cutler","year":"2021","journal-title":"J\u00a0Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2024.04.061_bib10","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1213\/ANE.0000000000005953","article-title":"The association between angiotensin II and renin kinetics in patients after cardiac surgery","volume":"134","author":"Meersch","year":"2022","journal-title":"Anesth Analg"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122400312X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000709122400312X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:17:44Z","timestamp":1762103864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000709122400312X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S000709122400312X"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2024.04.061","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II treatment of hypotension in noncardiac surgery: an initial dose-finding study","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2024.04.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}