{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:08:06Z","timestamp":1790878086345,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bja.2024.11.026","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T15:40:44Z","timestamp":1736523644000},"page":"641-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-4096","authenticated-orcid":false,"given":"Anna","family":"Littlejohns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-1739","authenticated-orcid":false,"given":"Philip M.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Savic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Mistry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2681-2288","authenticated-orcid":false,"given":"Louise","family":"Savic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2024.11.026_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jaci.2011.03.003","article-title":"Groupe d'Etudes des R\u00e9actions Anaphylacto\u00efdes Peranesth\u00e9siques. Anaphylaxis during anesthesia in France: an 8-year national survey","volume":"128","author":"Mertes","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bja.2024.11.026_bib2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/all.12426","article-title":"Fatal anaphylaxis with neuromuscular blocking agents: a risk factor and management analysis","volume":"69","author":"Reitter","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bja.2018.04.014","article-title":"Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6)","volume":"121","author":"Harper","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/pds.1196","article-title":"Adverse effects of neuromuscular blocking agents based on yellow card reporting in the U.K.: are there differences between males and females?","volume":"15","author":"Light","year":"2006","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.bja.2024.11.026_bib5","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.bja.2019.01.027","article-title":"Comparative epidemiology of suspected perioperative hypersensitivity reactions","volume":"123","author":"Mertes","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib6","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1016\/j.bja.2019.03.018","article-title":"The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status","volume":"123","author":"Garvey","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2222.2009.03404.x","article-title":"BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesia","volume":"40","author":"Ewan","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs - an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bja.2023.02.026","article-title":"Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study","volume":"131","author":"Mertes","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coi.2021.03.011","article-title":"Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs","volume":"72","author":"Ali","year":"2021","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.bja.2024.11.026_bib11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.18176\/jiaci.0557","article-title":"MRGPRX2 and immediate drug hypersensitivity: insights from cultured human mast cells","volume":"31","author":"Elst","year":"2021","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.bja.2024.11.026_bib12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/cea.14487","article-title":"Mast cell versus basophil activation test in allergy: current status","volume":"54","author":"Ebo","year":"2024","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib13","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1111\/all.14747","article-title":"Basophil activation test: mechanisms and considerations for use in clinical trials and clinical practice","volume":"76","author":"Santos","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/cea.12344","article-title":"Predictive value of allergy tests for neuromuscular blocking agents: tackling an unmet need","volume":"44","author":"Leysen","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","article-title":"Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations","volume":"58","author":"Aberer","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib16","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12350","article-title":"International Consensus on drug allergy","volume":"69","author":"Demoly","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib17","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/EJA.0000000000002033","article-title":"Neuromuscular blocking agent drug challenge: a literature review and protocol proposal with biological evaluation","volume":"41","author":"Gouel-Ch\u00e9ron","year":"2024","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.bja.2024.11.026_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40521-016-0078-0","article-title":"Perioperative hypersensitivity reactions: diagnosis, treatment and evaluation","volume":"3","author":"Garvey","year":"2016","journal-title":"Curr Treat Options Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib19","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.bja.2019.03.010","article-title":"Optimising diagnostics in perioperative allergy","volume":"123","author":"Opstrup","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib20","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.bja.2019.04.044","article-title":"Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations","volume":"123","author":"Garvey","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib21","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1111\/all.13820","article-title":"An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions","volume":"74","author":"Garvey","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.bja.2024.11.026_bib22","first-page":"318","article-title":"Intravenous provocation with neuromuscular blocking agents in the investigation of perioperative anaphylaxis - preliminary findings from the Danish Anaesthesia Allergy Centre (DAAC)","volume":"35","author":"Melchiors","year":"2018","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.bja.2024.11.026_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/ACI.0000000000000543","article-title":"Drug provocation testing: risk stratification is key","volume":"19","author":"Garvey","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.bja.2024.11.026_bib24","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/j.bja.2019.03.038","article-title":"Awake intravenous provocation with small doses of neuromuscular blocking agent in patients with suspected allergy: experiences from the Dutch Perioperative Allergy Centre","volume":"123","author":"van Cuilenborg","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib25","first-page":"44","article-title":"Mechanisms of hypersensitivity reactions induced by drugs","volume":"90","author":"Franceschini","year":"2019","journal-title":"Acta Biomed"},{"key":"10.1016\/j.bja.2024.11.026_bib26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000453265","article-title":"Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms","volume":"171","author":"Pichler","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.bja.2024.11.026_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.0105-1873.2003.00157.x","article-title":"Experimental systemic contact dermatitis from nickel: a dose-response study","volume":"49","author":"Jensen","year":"2003","journal-title":"Contact Dermat"},{"key":"10.1016\/j.bja.2024.11.026_bib28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bja.2021.05.026","article-title":"DALES, Drug Allergy Labels in Elective Surgical patients: a prospective, multicentre cross-sectional study of prevalence, nature and anaesthetists\u2019 approach to management","volume":"127","author":"Thomas","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib29","first-page":"374","article-title":"[The effect of priming dose of vecuronium on the diaphragm and the hypothenar muscle]","volume":"43","author":"Tatsumi","year":"1994","journal-title":"Masui"},{"key":"10.1016\/j.bja.2024.11.026_bib30","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/bja\/59.12.1528","article-title":"Side effects and changes in pulmonary function after fixed dose precurarization with alcuronium, pancuronium or vecuronium","volume":"59","author":"Motsch","year":"1987","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2024.11.026_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.18176\/jiaci.0236","article-title":"Practical guidelines for perioperative hypersensitivity reactions","volume":"28","author":"Laguna","year":"2018","journal-title":"J\u00a0Investig Allergol Clin Immunol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091224007165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091224007165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:55:32Z","timestamp":1774256132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091224007165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0007091224007165"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2024.11.026","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug challenge testing: a critical step in the investigation of neuromuscular blocking agent hypersensitivity","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2024.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}