{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:41:28Z","timestamp":1787244088548,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD114678"],"award-info":[{"award-number":["R01HD114678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bja.2025.01.014","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T15:37:36Z","timestamp":1740497856000},"page":"903-905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["What's old is new again: opioid and benzodiazepine actions on ventilation, a reminder of the importance of knowing one's drugs"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-5453","authenticated-orcid":false,"given":"Konrad","family":"Meissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-922X","authenticated-orcid":false,"given":"Evan D.","family":"Kharasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.01.014_bib1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/00000542-199011000-00005","article-title":"Frequent hypoxemia and apnea after sedation with midazolam and fentanyl","volume":"73","author":"Bailey","year":"1990","journal-title":"Anesthesiol"},{"key":"10.1016\/j.bja.2025.01.014_bib2","doi-asserted-by":"crossref","first-page":"j760","DOI":"10.1136\/bmj.j760","article-title":"Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis","volume":"356","author":"Sun","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2025.01.014_bib3","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bja.2024.11.047","article-title":"Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers.","volume":"134","author":"Gershuny","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.01.014_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/imj.1967.16.1.20","article-title":"A\u00a0clinical method for assessing the ventilatory response to carbon dioxide","volume":"16","author":"Read","year":"1967","journal-title":"Australas Ann Med"},{"key":"10.1016\/j.bja.2025.01.014_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/ALN.0000000000000914","article-title":"Wherefore gabapentinoids? Was there rush too soon to judgment?","volume":"124","author":"Kharasch","year":"2016","journal-title":"Anesthesiol"},{"key":"10.1016\/j.bja.2025.01.014_bib6","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/00000542-200406000-00007","article-title":"A\u00a0response surface analysis of propofol-remifentanil pharmacodynamic interaction in volunteers","volume":"100","author":"Kern","year":"2004","journal-title":"Anesthesiol"},{"key":"10.1016\/j.bja.2025.01.014_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/bja\/aew312","article-title":"Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration","volume":"118","author":"van den Berg","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.01.014_bib8","series-title":"Key Substance Use and Mental Health Indicators in the United States: Results from the 2022 National Survey on Drug Use and Health","year":"2023"},{"key":"10.1016\/j.bja.2025.01.014_bib10","series-title":"Benzodiazepines and opioids","year":"2022"},{"key":"10.1016\/j.bja.2025.01.014_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6501e1","article-title":"CDC guideline for prescribing opioids for chronic pain \u2013 United States, 2016","volume":"65","author":"Dowell","year":"2016","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.bja.2025.01.014_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7103a1","article-title":"CDC clinical practice guideline for prescribing opioids for pain \u2013 United States, 2022","volume":"71","author":"Dowell","year":"2022","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.bja.2025.01.014_bib13","series-title":"Package insert Oxycontin","year":"2023"},{"key":"10.1016\/j.bja.2025.01.014_bib14","first-page":"1","article-title":"Warnings unheeded: the risks of co-prescribing opioids and benzodiazepines","volume":"23","author":"Babalonis","year":"2015","journal-title":"Pain Clin Updates"},{"key":"10.1016\/j.bja.2025.01.014_bib15","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.8325","article-title":"Rates of physician coprescribing of opioids and benzodiazepines after the release of the centers for disease control and prevention guidelines in 2016","volume":"2","author":"Jeffery","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bja.2025.01.014_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1124\/jpet.123.001651","article-title":"Hydrocodone, oxycodone, and morphine metabolism and drug\u2013drug interactions","volume":"387","author":"Coates","year":"2023","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.bja.2025.01.014_bib17","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/acschemneuro.0c00810","article-title":"Drug\u2013drug interaction between oxycodone and diazepam by a combined in silico pharmacokinetic and pharmacodynamic modeling approach","volume":"12","author":"Ji","year":"2021","journal-title":"ACS Chemical Neurosci"},{"key":"10.1016\/j.bja.2025.01.014_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/ALN.0000000000004065","article-title":"Opioids and public\u00a0health: the prescription opioid ecosystem and need for improved management","volume":"136","author":"Kharasch","year":"2022","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2025.01.014_bib19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/ALN.0000000000002664","article-title":"Opioid sensitivity in children with and without obstructive sleep apnea","volume":"130","author":"Montana","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2025.01.014_bib20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bja.2024.10.042","article-title":"Opioid use in treated and untreated obstructive sleep apnoea: remifentanil pharmacokinetics and pharmacodynamics in adult volunteers","volume":"134","author":"Maharaj","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.01.014_bib21","first-page":"21","article-title":"No patient shall be harmed by opioid-induced respiratory depression","volume":"26","author":"Weinger","year":"2011","journal-title":"APSF Newsl"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225000273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225000273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:48:07Z","timestamp":1775004487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225000273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0007091225000273"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.01.014","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What's old is new again: opioid and benzodiazepine actions on ventilation, a reminder of the importance of knowing one's drugs","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2024.11.047","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}