{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:40:53Z","timestamp":1790800853127,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bja.2025.02.042","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T15:58:40Z","timestamp":1746806320000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of intraoperative dexmedetomidine on clear cell renal cell carcinoma progression: a retrospective cohort study"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6735-4588","authenticated-orcid":false,"given":"Ryan","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8156-8875","authenticated-orcid":false,"given":"Raj G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cortes-Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-0314","authenticated-orcid":false,"given":"Juan J.","family":"Guerra-Londono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6790-2713","authenticated-orcid":false,"given":"Huang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvik","family":"Gundre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Napa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-1682","authenticated-orcid":false,"given":"Juan P.","family":"Cata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.02.042_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bja.2025.02.042_bib2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/CBM-2011-0176","article-title":"Renal cell carcinoma","volume":"9","author":"Cairns","year":"2011","journal-title":"Cancer Biomark"},{"key":"10.1016\/j.bja.2025.02.042_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ijc.20618","article-title":"Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies","volume":"114","author":"Hunt","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bja.2025.02.042_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.annonc.2024.05.537","article-title":"Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"35","author":"Powles","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bja.2025.02.042_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.eursup.2012.04.003","article-title":"Treatment of locally advanced renal cell carcinoma","volume":"11","author":"H\u00fcsch","year":"2012","journal-title":"Eur Urol Suppl"},{"key":"10.1016\/j.bja.2025.02.042_bib6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(09)60229-4","article-title":"Renal cell carcinoma","volume":"373","author":"Rini","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2025.02.042_bib7","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1470-2045(09)70240-2","article-title":"Resistance to targeted therapy in renal-cell carcinoma","volume":"10","author":"Rini","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.bja.2025.02.042_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bja.2025.02.042_bib9","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1038\/s41467-020-17873-3","article-title":"HIF-1\u03b1 and HIF-2\u03b1 differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice","volume":"11","author":"Hoefflin","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.bja.2025.02.042_bib10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJMra1601333","article-title":"Systemic therapy for metastatic renal-cell carcinoma","volume":"376","author":"Choueiri","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.02.042_bib11","doi-asserted-by":"crossref","first-page":"44124","DOI":"10.1039\/C7RA01768E","article-title":"miRNA-21 promotes renal carcinoma cell invasion in a microfluidic device","volume":"7","author":"Wang","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.bja.2025.02.042_bib12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","article-title":"Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine","volume":"56","author":"Weerink","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.bja.2025.02.042_bib13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1046\/j.1365-2044.1999.00659.x","article-title":"alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role","volume":"54","author":"Khan","year":"1999","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2025.02.042_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2409334","article-title":"Intraoperative dexmedetomidine administration and acute kidney injury in patients undergoing unilateral partial nephrectomy: a retrospective study","volume":"46","author":"Wong","year":"2024","journal-title":"Ren Fail"},{"key":"10.1016\/j.bja.2025.02.042_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bja.2017.11.004","article-title":"Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers","volume":"120","author":"Lavon","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.02.042_bib16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bja.2019.07.027","article-title":"Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis","volume":"123","author":"Wang","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.02.042_bib17","first-page":"931","article-title":"Dexmedetomidine promotes angiogenesis and vasculogenic mimicry in human hepatocellular carcinoma through \u03b1 (2)-AR\/HIF-1\u03b1\/VEGFA pathway","volume":"35","author":"Fang","year":"2022","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.bja.2025.02.042_bib18","first-page":"4820","article-title":"Dexmedetomidine enhances hypoxia-induced cancer cell progression","volume":"18","author":"Chen","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.bja.2025.02.042_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4103\/joacp.JOACP_299_16","article-title":"Intraoperative use of dexmedetomidine is associated with decreased overall survival after lung cancer surgery","volume":"33","author":"Cata","year":"2017","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"10.1016\/j.bja.2025.02.042_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2023.111068","article-title":"Effect of intraoperative dexmedetomidine on long-term survival in older patients after major noncardiac surgery: 3-year follow-up of a randomized trial","volume":"86","author":"Xing","year":"2023","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.bja.2025.02.042_bib21","article-title":"Association between intraoperative dexmedetomidine and all-cause mortality and recurrence after laparoscopic resection of colorectal cancer: follow-up analysis of a previous randomized controlled trial","volume":"13","author":"Hu","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.bja.2025.02.042_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.749003","article-title":"Effects of perioperative dexmedetomidine on immunomodulation in uterine cancer surgery: a randomized, controlled trial","volume":"11","author":"Cho","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.bja.2025.02.042_bib23","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3390\/ijms22052622","article-title":"TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues","volume":"22","author":"Bartha","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bja.2025.02.042_bib24","doi-asserted-by":"crossref","DOI":"10.2196\/27633","article-title":"Web-based survival analysis tool tailored for medical research (KMplot): development and implementation","volume":"23","author":"L\u00e1nczky","year":"2021","journal-title":"J Med Internet Res"},{"key":"10.1016\/j.bja.2025.02.042_bib25","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gyorffy","year":"2024","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.bja.2025.02.042_bib26","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1038\/s41598-021-84787-5","article-title":"Pancancer survival analysis of cancer hallmark genes","volume":"11","author":"Nagy","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.bja.2025.02.042_bib27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2025.02.042_bib28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/pds.3945","article-title":"A synthesis of oral morphine equivalents (OME) for opioid utilisation studies","volume":"25","author":"Nielsen","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.bja.2025.02.042_bib29","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1111\/bcp.14030","article-title":"Prognostic significance of \u03b1- and \u03b22-adrenoceptor gene expression in breast cancer patients","volume":"85","author":"Rivero","year":"2019","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.bja.2025.02.042_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/carcin\/bgae056","article-title":"ADRA2A promotes the classical\/progenitor subtype and reduces disease aggressiveness of pancreatic cancer","volume":"45","author":"Moreno","year":"2024","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bja.2025.02.042_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38241","article-title":"Study on the effects of intraoperative administration of dexmedetomidine on the prognosis and survival outcomes of patients with colorectal cancer","volume":"10","author":"Ren","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bja.2025.02.042_bib32","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3390\/jpm11090912","article-title":"Effect of dexmedetomidine on biochemical recurrence in patients after robot-assisted laparoscopic radical prostatectomy: a retrospective study","volume":"11","author":"Yoo","year":"2021","journal-title":"J Pers Med"},{"key":"10.1016\/j.bja.2025.02.042_bib33","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1016\/j.bja.2020.06.036","article-title":"Impact of intraoperative opioid and adjunct analgesic use on renal cell carcinoma recurrence: role for onco-anaesthesia","volume":"125","author":"Silagy","year":"2020","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.02.042_bib34","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1002\/cam4.2654","article-title":"Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: a prospective randomized controlled trial","volume":"8","author":"Liu","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.bja.2025.02.042_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00280-019-03863-w","article-title":"Exposure time versus cytotoxicity for anticancer agents","volume":"84","author":"Evans","year":"2019","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.bja.2025.02.042_bib36","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrc1951","article-title":"The NCI60 human tumour cell line anticancer drug screen","volume":"6","author":"Shoemaker","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bja.2025.02.042_bib37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3892\/ol.2023.13722","article-title":"Platycodin D inhibits the proliferation, invasion and migration of endometrial cancer cells by blocking the PI3K\/Akt signaling pathway via ADRA2A upregulation","volume":"25","author":"Ni","year":"2023","journal-title":"Oncol Lett"},{"key":"10.1016\/j.bja.2025.02.042_bib38","article-title":"The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus","volume":"14","author":"Xie","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bja.2025.02.042_bib39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12253-015-0010-0","article-title":"ADRA2A germline gene polymorphism is associated to the severity, but not to the risk, of breast cancer","volume":"22","author":"Kaabi","year":"2016","journal-title":"Pathol Oncol Res"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225002077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225002077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:36:12Z","timestamp":1782952572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225002077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0007091225002077"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.02.042","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of intraoperative dexmedetomidine on clear cell renal cell carcinoma progression: a retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.02.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}