{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:57:06Z","timestamp":1790823426403,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bja.2025.05.026","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:15:26Z","timestamp":1751958926000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hydroxocobalamin for vasoplegia in cardiac surgery: a retrospective cohort analysis"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7285-1890","authenticated-orcid":false,"given":"Luai","family":"Zakaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-0246","authenticated-orcid":false,"given":"Karan","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-0945","authenticated-orcid":false,"given":"Dongsheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kelava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-0123","authenticated-orcid":false,"given":"Haytham","family":"Elgharably","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-891X","authenticated-orcid":false,"given":"Ashish K.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-7223","authenticated-orcid":false,"given":"Sanchit","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-3519","authenticated-orcid":false,"given":"Benjamin","family":"Hohlfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-0347","authenticated-orcid":false,"given":"Andrej","family":"Alfirevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-1828","authenticated-orcid":false,"given":"Andra E.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0677","authenticated-orcid":false,"given":"Nikolaos J.","family":"Skubas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-3077","authenticated-orcid":false,"given":"Daniel I.","family":"Sessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.05.026_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/2050312120935466","article-title":"Vasoplegia after cardiopulmonary bypass: a narrative review of pathophysiology and emerging targeted therapies","volume":"8","author":"Barnes","year":"2020","journal-title":"SAGE Open Med"},{"key":"10.1016\/j.bja.2025.05.026_bib2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/j.semtcvs.2010.09.007","article-title":"Vasoplegia during cardiac surgery: current concepts and management","volume":"22","author":"Fischer","year":"2010","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bja.2025.05.026_bib3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMra002709","article-title":"The pathogenesis of vasodilatory shock","volume":"345","author":"Landry","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.05.026_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13054-018-1967-3","article-title":"Vasoplegia treatments: the past, the present, and the future","volume":"22","author":"Levy","year":"2018","journal-title":"Crit Care (London, England)"},{"key":"10.1016\/j.bja.2025.05.026_bib5","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1053\/j.jvca.2025.02.047","article-title":"Vasoplegic syndrome in cardiac surgery: a narrative review of etiologic mechanisms and therapeutic options","volume":"39","author":"Polyak","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib6","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.jvca.2025.02.027","article-title":"Vasoplegia in cardiac surgery: a systematic review and meta-analysis of current definitions and their influence on clinical outcomes","volume":"39","author":"Papazisi","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chest.2017.12.021","article-title":"Management of refractory vasodilatory shock","volume":"154","author":"Jentzer","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.bja.2025.05.026_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/17512433.2022.2110067","article-title":"The pharmacotherapeutic options in patients with catecholamine-resistant vasodilatory shock","volume":"15","author":"Albertson","year":"2022","journal-title":"Exp Rev Clin Pharmacol"},{"key":"10.1016\/j.bja.2025.05.026_bib9","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s12630-019-01449-x","article-title":"Vitamin B12 for the treatment of vasoplegia in cardiac surgery and liver transplantation: a narrative review of cases and potential biochemical mechanisms","volume":"66","author":"Charles","year":"2019","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bja.2025.05.026_bib10","article-title":"The durability of intravenous hydroxocobalamin in vasoplegia","volume":"15","author":"Blaha","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.bja.2025.05.026_bib11","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.athoracsur.2013.08.050","article-title":"The use of high-dose hydroxocobalamin for vasoplegic syndrome","volume":"97","author":"Roderique","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.05.026_bib12","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1053\/j.jvca.2023.08.145","article-title":"Intraoperative versus postoperative hydroxocobalamin for vasoplegic shock in cardiothoracic surgery","volume":"37","author":"Khandekar","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib13","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1053\/j.jvca.2023.07.015","article-title":"Hydroxocobalamin versus methylene blue for the treatment of vasoplegic shock associated with cardiopulmonary bypass","volume":"37","author":"Hiruy","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib14","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1053\/j.jvca.2023.12.016","article-title":"Adverse clinical effects associated with non-catecholamine pharmacologic agents for treatment of vasoplegic syndrome in adult cardiac surgery","volume":"38","author":"Hwang","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-023-04322-y","article-title":"An updated \u2018norepinephrine equivalent\u2019 score in intensive care as a marker of shock severity","volume":"27","author":"Kotani","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.05.026_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/aje\/kwy252","article-title":"Risk-set matching to assess the impact of hospital-acquired bloodstream infections","volume":"188","author":"Watson","year":"2019","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.bja.2025.05.026_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the treatment of vasodilatory shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.05.026_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13613-019-0536-5","article-title":"Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial","volume":"9","author":"Ham","year":"2019","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2025.05.026_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.jvca.2020.08.001","article-title":"Treatment with angiotensin II is associated with rapid blood pressure response and vasopressor sparing in patients with vasoplegia after cardiac surgery: a Post-Hoc Analysis of Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) Study","volume":"35","author":"Klijian","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.05.026_bib20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.athoracsur.2014.05.073","article-title":"Prediction of costs and length of stay in coronary artery bypass grafting","volume":"98","author":"Osnabrugge","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.05.026_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hrtlng.2020.11.003","article-title":"Extended duration infusion of high-dose hydroxocobalamin for vasoplegic syndrome following cardiac surgery","volume":"50","author":"Seelhammer","year":"2021","journal-title":"Heart Lung"},{"key":"10.1016\/j.bja.2025.05.026_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s13054-024-05212-7","article-title":"Non-adrenergic vasopressors for vasodilatory shock or perioperative vasoplegia: a meta-analysis of randomized controlled trials","volume":"28","author":"Kotani","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.05.026_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/0885066609340519","article-title":"Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress","volume":"24","author":"D\u00fcnser","year":"2009","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.bja.2025.05.026_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142605","article-title":"Non-adrenergic vasopressors in patients with or at risk for vasodilatory shock. A systematic review and meta-analysis of randomized trials","volume":"10","author":"Belletti","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2025.05.026_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-018-2102-1","article-title":"Definitions and pathophysiology of vasoplegic shock","volume":"22","author":"Lambden","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.05.026_bib26","first-page":"1603","article-title":"Treatment-effect heterogeneity in hemodynamic responses to hydroxocobalamin","volume":"38","author":"Zakaria","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225003393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225003393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:21:40Z","timestamp":1790821300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225003393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0007091225003393"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.05.026","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxocobalamin for vasoplegia in cardiac surgery: a retrospective cohort analysis","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}