{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:58:14Z","timestamp":1790823494084,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bja.2025.07.052","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:29:31Z","timestamp":1755736171000},"page":"844-846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the contributors to vasorelaxation during vasoplegia from cardiopulmonary bypass"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-5186","authenticated-orcid":false,"given":"Patrick M.","family":"Wieruszewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-7213","authenticated-orcid":false,"given":"Jamel P.","family":"Ortoleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.07.052_bib1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0022-5223(94)70355-8","article-title":"Vasoplegic syndrome: a new dilemma","volume":"107","author":"Gomes","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bja.2025.07.052_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-2743-8","article-title":"Vasoplegic syndrome following cardiothoracic surgery-review of pathophysiology and update of treatment options","volume":"24","author":"Busse","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.07.052_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ccc.2023.06.002","article-title":"Management of vasoplegic shock in the cardiovascular intensive care unit after cardiac surgery","volume":"40","author":"Suero","year":"2024","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.bja.2025.07.052_bib4","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/j.jvca.2025.01.012","article-title":"Vasoplegia in heart, lung, or liver transplantation: a narrative review","volume":"39","author":"Ortoleva","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13054-022-03911-7","article-title":"Vasopressor choice and timing in vasodilatory shock","volume":"26","author":"Wieruszewski","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.07.052_bib6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bja.2025.05.026","article-title":"Hydroxocobalamin for vasoplegia in cardiac surgery: a retrospective cohort analysis","volume":"135","author":"Zakaria","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.07.052_bib7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1053\/j.jvca.2018.08.017","article-title":"Hydroxocobalamin for the treatment of vasoplegia: a review of current literature and considerations for use","volume":"33","author":"Shapeton","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib8","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1053\/j.jvca.2023.04.006","article-title":"Hydroxocobalamin for vasodilatory hypotension in shock: a systematic review with meta-analysis for comparison to methylene blue","volume":"37","author":"Brokmeier","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hrtlng.2020.11.003","article-title":"Extended duration infusion of high-dose hydroxocobalamin for vasoplegic syndrome following cardiac surgery","volume":"50","author":"Seelhammer","year":"2021","journal-title":"Heart Lung"},{"key":"10.1016\/j.bja.2025.07.052_bib10","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.athoracsur.2013.08.050","article-title":"The use of high-dose hydroxocobalamin for vasoplegic syndrome","volume":"97","author":"Roderique","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.07.052_bib11","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1053\/j.jvca.2023.08.145","article-title":"Intraoperative versus postoperative hydroxocobalamin for vasoplegic shock in cardiothoracic surgery","volume":"37","author":"Khandekar","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib12","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1053\/j.jvca.2025.02.001","article-title":"Use of hydroxycobolamin in the prevention of vasoplegic syndrome in adult patients undergoing cardiopulmonary bypass: a controlled prospective trial","volume":"39","author":"Salah","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/j.jvca.2016.05.029","article-title":"Low-cardiac-output syndrome after cardiac surgery","volume":"31","author":"Lomivorotov","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.07.052_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/bja\/aep018","article-title":"Effects of phenylephrine on the sublingual microcirculation during cardiopulmonary bypass","volume":"102","author":"Maier","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.07.052_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/j.jvca.2023.10.032","article-title":"Timing is everything: two decades of nitric oxide modulation in vasoplegia","volume":"38","author":"Pisano","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225005033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225005033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:20:22Z","timestamp":1790821222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225005033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0007091225005033"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.07.052","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the contributors to vasorelaxation during vasoplegia from cardiopulmonary bypass","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.07.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.05.026","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}