{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:01:44Z","timestamp":1780120904127,"version":"3.54.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016819","name":"Octapharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bja.2025.08.060","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:07:17Z","timestamp":1760796437000},"page":"343-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-3225","authenticated-orcid":false,"given":"Daan P.","family":"van den Brink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-6529","authenticated-orcid":false,"given":"Bashar N.","family":"Hilderink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-1471","authenticated-orcid":false,"given":"Derek J.B.","family":"Kleinveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-4530","authenticated-orcid":false,"given":"Robert B.","family":"Klanderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Pareyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vanhoorelbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-6574","authenticated-orcid":false,"given":"Nicole P.","family":"Juffermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.08.060_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bja.2025.08.060_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3389\/fimmu.2019.01037","article-title":"Role of neutrophil extracellular traps and vesicles in regulating vascular endothelial permeability","volume":"10","author":"Ma","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.bja.2025.08.060_bib3","article-title":"Endothelial glycocalyx degradation in critical illness and injury","volume":"9","author":"Patterson","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.bja.2025.08.060_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13054-017-1605-5","article-title":"Shock induced endotheliopathy (SHINE) in acute critical illness \u2013 a unifying pathophysiologic mechanism","volume":"21","author":"Johansson","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.08.060_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/SHK.0000000000000473","article-title":"The endothelium in sepsis","volume":"45","author":"Ince","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.bja.2025.08.060_bib6","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.08.060_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00134-024-07369-9","article-title":"European Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluids","volume":"50","author":"Arabi","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.08.060_bib8","doi-asserted-by":"crossref","first-page":"H363","DOI":"10.1152\/ajpheart.00687.2013","article-title":"Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding","volume":"306","author":"Zeng","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bja.2025.08.060_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220893","article-title":"Normal saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R\/p38 MAPK\/MK2 signaling pathways","volume":"14","author":"Cheung-Flynn","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2025.08.060_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13054-017-1745-7","article-title":"Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids","volume":"21","author":"Torres","year":"2017","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.08.060_bib11","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1097\/CCM.0b013e318211ff6e","article-title":"Human serum albumin improves endothelial dysfunction and survival during experimental endotoxemia: concentration-dependent properties","volume":"39","author":"Kremer","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2025.08.060_bib12","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1056\/NEJMoa040232","article-title":"A comparison of albumin and saline for fluid resuscitation in the intensive care unit","volume":"350","author":"Finfer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.08.060_bib13","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa1305727","article-title":"Albumin replacement in patients with severe sepsis or septic shock","volume":"370","author":"Caironi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.08.060_bib14","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/bmj.38985.398704.7C","article-title":"Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study","volume":"333","author":"Finfer","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2025.08.060_bib15","doi-asserted-by":"crossref","first-page":"S301","DOI":"10.1111\/trf.16462","article-title":"Plasma as a resuscitation fluid for volume-depleted shock: Potential benefits and risks","volume":"61","author":"van den Brink","year":"2021","journal-title":"Transfusion"},{"key":"10.1016\/j.bja.2025.08.060_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13054-019-2369-x","article-title":"Resuscitation fluid choices to preserve the endothelial glycocalyx","volume":"23","author":"Milford","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.08.060_bib17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/jth.13953","article-title":"The role of ADAMTS-13 in the coagulopathy of sepsis","volume":"16","author":"Levi","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.bja.2025.08.060_bib18","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1182\/bloodadvances.2021004404","article-title":"Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis","volume":"5","author":"Kleinveld","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.bja.2025.08.060_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0000000000000918","article-title":"Plasma resuscitation improved survival in a cecal ligation and puncture rat model of sepsis","volume":"49","author":"Chang","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.bja.2025.08.060_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40635-023-00549-9","article-title":"The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model","volume":"11","author":"van den Brink","year":"2023","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.bja.2025.08.060_bib21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1213\/ANE.0b013e318210385c","article-title":"Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock","volume":"112","author":"Kozar","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bja.2025.08.060_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/SHK.0b013e31829f91fc","article-title":"Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1","volume":"40","author":"Peng","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.bja.2025.08.060_bib23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/TA.0b013e3182a92514","article-title":"Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats","volume":"75","author":"Torres","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.bja.2025.08.060_bib24","doi-asserted-by":"crossref","first-page":"H1468","DOI":"10.1152\/ajpheart.00006.2016","article-title":"Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids","volume":"310","author":"Torres Filho","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bja.2025.08.060_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13054-015-0828-6","article-title":"Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial","volume":"19","author":"Straat","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.08.060_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.135350","article-title":"Prehospital plasma is associated with distinct biomarker expression following injury","volume":"5","author":"Gruen","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bja.2025.08.060_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.bja.2025.08.060_bib28","unstructured":"Urbaniak, G. C., & Plous, S. (2013). Research Randomizer (Version 4.0) [Computer program] [cited 01-07-2023]. http:\/\/www.randomizer.org\/"},{"key":"10.1016\/j.bja.2025.08.060_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biochi.2018.06.014","article-title":"Experimental human endotoxemia as a model of systemic inflammation","volume":"159","author":"van Lier","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.bja.2025.08.060_bib30","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/jth.14747","article-title":"Anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura do not hamper ELISA-based quantification of ADAMTS13 antigen","volume":"18","author":"Dekimpe","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.bja.2025.08.060_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/ejh.13094","article-title":"Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13","author":"Schelpe","year":"2018","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.bja.2025.08.060_bib32","doi-asserted-by":"crossref","DOI":"10.3791\/53913","article-title":"Intravenous endotoxin challenge in healthy humans: an experimental platform to investigate and modulate systemic inflammation","author":"Fullerton","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.bja.2025.08.060_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2025.08.060_bib34","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.2147\/JIR.S331020","article-title":"Syndecan-1 shedding by matrix metalloproteinase-9 signaling regulates alveolar epithelial tight junction in lipopolysaccharide-induced early acute lung injury","volume":"14","author":"Zhang","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.bja.2025.08.060_bib35","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/trf.17939","article-title":"Plasma as endothelial rescue in septic shock: a randomized, phase 2a pilot trial","volume":"64","author":"Clausen","year":"2024","journal-title":"Transfusion"},{"key":"10.1016\/j.bja.2025.08.060_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108254","article-title":"Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain","volume":"9","author":"Martin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2025.08.060_bib37","doi-asserted-by":"crossref","first-page":"C87","DOI":"10.1152\/ajpcell.00585.2006","article-title":"Cyclic strain and motion control produce opposite oxidative responses in two human endothelial cell types","volume":"293","author":"Sung","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bja.2025.08.060_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.003126","article-title":"Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload-induced heart failure","volume":"5","author":"Salvador","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.bja.2025.08.060_bib39","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1097\/j.pain.0000000000000256","article-title":"Inflammation-induced pain sensitization in men and women: does sex matter in experimental endotoxemia?","volume":"156","author":"Wegner","year":"2015","journal-title":"Pain"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225006385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225006385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:24:39Z","timestamp":1780118679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225006385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0007091225006385"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.08.060","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.08.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}