{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:06:58Z","timestamp":1793502418410,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["81620108012"],"award-info":[{"award-number":["81620108012"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1308402"],"award-info":[{"award-number":["2017YFC1308402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007547","name":"Air Force Medical University","doi-asserted-by":"publisher","award":["XJZT24LZ04"],"award-info":[{"award-number":["XJZT24LZ04"]}],"id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007547","name":"Air Force Medical University","doi-asserted-by":"publisher","award":["XJZT24JC22"],"award-info":[{"award-number":["XJZT24JC22"]}],"id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016073","name":"Key Technologies Research and Development Program of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970448"],"award-info":[{"award-number":["81970448"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bja.2025.09.026","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:59:24Z","timestamp":1763416764000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Dexmedetomidine on Outcomes After Cardiac Surgery (DOCS): a randomised double-blind, placebo-controlled trial"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-4479","authenticated-orcid":false,"given":"Chong","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-3541","authenticated-orcid":false,"given":"Ziyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiange","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lini","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiezheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihe","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1261","authenticated-orcid":false,"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-7131","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-9067","authenticated-orcid":false,"given":"Hailong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.09.026_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2288-12-28","article-title":"Hospital-level associations with 30-day patient mortality after cardiac surgery: a tutorial on the application and interpretation of marginal and multilevel logistic regression","volume":"12","author":"Sanagou","year":"2012","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.bja.2025.09.026_bib2","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1161\/CIRCULATIONAHA.112.000936","article-title":"Perioperative dexmedetomidine improves outcomes of cardiac surgery","volume":"127","author":"Ji","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2025.09.026_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/msy.1999.98664","article-title":"The incidence and nature of surgical adverse events in Colorado and Utah in 1992","volume":"126","author":"Gawande","year":"1999","journal-title":"Surgery"},{"key":"10.1016\/j.bja.2025.09.026_bib4","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.athoracsur.2009.05.055","article-title":"The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 3\u2014valve plus coronary artery bypass grafting surgery","volume":"88","author":"Shahian","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.athoracsur.2022.12.033","article-title":"The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2022 update on outcomes and research","volume":"115","author":"Kim","year":"2023","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jtcvs.2017.08.144","article-title":"Cost of individual complications following coronary artery bypass grafting","volume":"155","author":"Mehaffey","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib7","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1345\/aph.1M310","article-title":"An updated focused review of dexmedetomidine in adults","volume":"43","author":"Gerlach","year":"2009","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.bja.2025.09.026_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jss.2014.10.008","article-title":"Effects of dexmedetomidine on patients undergoing radical gastrectomy","volume":"194","author":"Wang","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.bja.2025.09.026_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1053\/j.jvca.2019.09.011","article-title":"Effect of dexmedetomidine on cardiac surgery-associated acute kidney injury: a meta-analysis with trial sequential analysis of randomized controlled trials","volume":"34","author":"Peng","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.09.026_bib10","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","article-title":"Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial","volume":"388","author":"Su","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bja.2025.09.026_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/j.jvca.2013.06.022","article-title":"Perioperative dexmedetomidine improves mortality in patients undergoing coronary artery bypass surgery","volume":"28","author":"Ji","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.09.026_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077446","article-title":"Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bja.2025.09.026_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.clinthera.2018.10.022","article-title":"Effects of perioperative dexmedetomidine on postoperative mortality and morbidity: a systematic review and meta-analysis","volume":"41","author":"Peng","year":"2019","journal-title":"Clin Ther"},{"key":"10.1016\/j.bja.2025.09.026_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1001\/jamasurg.2019.1153","article-title":"Guidelines for perioperative care in cardiac surgery: Enhanced Recovery After Surgery Society recommendations","volume":"154","author":"Engelman","year":"2019","journal-title":"JAMA Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/EJA.0000000000001876","article-title":"Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients","volume":"41","author":"Aldecoa","year":"2024","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.bja.2025.09.026_bib16","first-page":"CD004126","article-title":"Alpha-2 adrenergic agonists for the prevention of cardiac complications among adults undergoing surgery","volume":"3","author":"Duncan","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bja.2025.09.026_bib17","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1164\/rccm.201710-2150OC","article-title":"Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery","volume":"198","author":"Lei","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2025.09.026_bib18","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.athoracsur.2013.10.040","article-title":"In-hospital mortality after cardiac surgery: patient characteristics, timing, and association with postoperative length of intensive care unit and hospital stay","volume":"97","author":"Mazzeffi","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejcts.2003.12.003","article-title":"Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence","volume":"25","author":"Anselmi","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/026765910101600505","article-title":"Systemic inflammation and cardiac surgery: an update","volume":"16","author":"Asimakopoulos","year":"2001","journal-title":"Perfusion"},{"key":"10.1016\/j.bja.2025.09.026_bib23","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1053\/j.jvca.2019.01.043","article-title":"Prevalence and clinical impact of systemic inflammatory reaction after cardiac surgery","volume":"33","author":"Squiccimarro","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.bja.2025.09.026_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bja.2019.07.027","article-title":"Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis","volume":"123","author":"Wang","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.09.026_bib25","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/jama.2017.2088","article-title":"Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial","volume":"317","author":"Kawazoe","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2025.09.026_bib26","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1016\/j.jss.2010.02.020","article-title":"Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats","volume":"167","author":"Yang","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.bja.2025.09.026_bib27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41569-019-0166-5","article-title":"Postoperative atrial fibrillation: mechanisms, manifestations and management","volume":"16","author":"Dobrev","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.bja.2025.09.026_bib28","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","article-title":"Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit","volume":"291","author":"Ely","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2025.09.026_bib29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/SLA.0000000000001582","article-title":"Acute and chronic kidney disease and cardiovascular mortality after major surgery","volume":"264","author":"Ozrazgat-Baslanti","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40256-019-00380-2","article-title":"Dexmedetomidine reduces atrial fibrillation after adult cardiac surgery: a meta-analysis of randomized controlled trials","volume":"20","author":"Liu","year":"2020","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.bja.2025.09.026_bib31","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1056\/NEJMoa1816476","article-title":"Volatile anesthetics versus total intravenous anesthesia for cardiac surgery","volume":"380","author":"Landoni","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.09.026_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.hlc.2014.11.014","article-title":"Procedure-specific cardiac surgeon volume associated with patient outcome following valve surgery, but not isolated CABG surgery","volume":"24","author":"Ch\u2019ng","year":"2015","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.bja.2025.09.026_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12871-022-01589-6","article-title":"Comparison between dexmedetomidine and propofol on outcomes after coronary artery bypass graft surgery: a retrospective study","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.bja.2025.09.026_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2253-15-17","article-title":"Adequate sedation with single-dose dexmedetomidine in patients undergoing transurethral resection of the prostate with spinal anaesthesia: a dose-response study by age group","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.bja.2025.09.026_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1365-2125.2003.02007.x","article-title":"Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications","volume":"57","author":"Mangoni","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.bja.2025.09.026_bib36","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1056\/NEJMoa1904710","article-title":"Early sedation with dexmedetomidine in critically ill patients","volume":"380","author":"Shehabi","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.09.026_bib37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/anae.15947","article-title":"Dexmedetomidine for adult cardiac surgery: a systematic review, meta-analysis and trial sequential analysis","volume":"78","author":"Poon","year":"2023","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2025.09.026_bib38","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2017.1505","article-title":"Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial","volume":"152","author":"Deiner","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.bja.2025.09.026_bib39","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/jama.2019.0234","article-title":"Effect of intravenous acetaminophen vs placebo combined with propofol or dexmedetomidine on postoperative delirium among older patients following cardiac surgery: the DEXACET randomized clinical trial","volume":"321","author":"Subramaniam","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.bja.2025.09.026_bib40","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201710-1995OC","article-title":"Low-dose nocturnal dexmedetomidine prevents ICU delirium. A randomized, placebo-controlled trial","volume":"197","author":"Skrobik","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bja.2025.09.026_bib41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jclinane.2018.06.046","article-title":"The association between intraoperative dexmedetomidine and 1 year morbidity and mortality after cardiac surgery: a propensity matched analysis of over 1400 patients","volume":"50","author":"Xu","year":"2018","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.bja.2025.09.026_bib42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13054-016-1480-5","article-title":"Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial","volume":"20","author":"Liu","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.09.026_bib43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bja.2018.04.046","article-title":"Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials","volume":"121","author":"Duan","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.09.026_bib44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jclinane.2018.06.045","article-title":"Perioperative dexmedetomidine reduces delirium after cardiac surgery: a meta-analysis of randomized controlled trials","volume":"50","author":"Wu","year":"2018","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.bja.2025.09.026_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12871-018-0472-1","article-title":"Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.bja.2025.09.026_bib46","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13054-016-1386-2","article-title":"Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study","volume":"20","author":"Conti","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.09.026_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0140-6736(20)30631-0","article-title":"Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial","volume":"396","author":"Turan","year":"2020","journal-title":"Lancet"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225006919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225006919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:21:07Z","timestamp":1780118467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225006919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0007091225006919"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.09.026","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Dexmedetomidine on Outcomes After Cardiac Surgery (DOCS): a randomised double-blind, placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}