{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:09:02Z","timestamp":1793171342225,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bja.2025.10.048","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T04:37:25Z","timestamp":1764650245000},"page":"542-551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-2519","authenticated-orcid":false,"given":"Martin","family":"Ruste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Rodemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-2019","authenticated-orcid":false,"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Amaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-9886","authenticated-orcid":false,"given":"Jean-Luc","family":"Fellahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Jacquet-Lagr\u00e8ze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.10.048_bib1","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.10.048_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5603\/AIT.2014.0060","article-title":"Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice","volume":"46","author":"Malbrain","year":"2014","journal-title":"Anaesthesiol Intensive Ther"},{"key":"10.1016\/j.bja.2025.10.048_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13613-020-00679-3","article-title":"Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)","volume":"10","author":"Malbrain","year":"2020","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bja.2025.10.048_bib4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s00134-022-06761-7","article-title":"Everything you need to know about deresuscitation","volume":"48","author":"Malbrain","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13054-022-04255-y","article-title":"A plea for personalization of the hemodynamic management of septic shock","volume":"26","author":"De Backer","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib6","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1007\/s00134-022-06808-9","article-title":"How can assessing hemodynamics help to assess volume status?","volume":"48","author":"De Backer","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrneph.2009.213","article-title":"Fluid balance and acute kidney injury","volume":"6","author":"Prowle","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.bja.2025.10.048_bib8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/sdi.12964","article-title":"Fluid balance management during continuous renal replacement therapy","volume":"34","author":"Prowle","year":"2021","journal-title":"Semin Dial"},{"key":"10.1016\/j.bja.2025.10.048_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13054-023-04496-5","article-title":"Hypovolemia with peripheral edema: what is wrong?","volume":"27","author":"Dull","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLOS Med"},{"key":"10.1016\/j.bja.2025.10.048_bib11","article-title":"Salzburg Intensive Care database (SICdb), a freely accessible intensive care database","author":"Rodemund","year":"2024","journal-title":"PhysioNet"},{"key":"10.1016\/j.bja.2025.10.048_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41597-024-03164-9","article-title":"Harnessing big data in critical care: exploring a new European dataset","volume":"11","author":"Rodemund","year":"2024","journal-title":"Sci Data"},{"key":"10.1016\/j.bja.2025.10.048_bib13","doi-asserted-by":"crossref","first-page":"E215","DOI":"10.1161\/01.CIR.101.23.e215","article-title":"PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals","volume":"101","author":"Goldberger","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bja.2025.10.048_bib15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00134-005-2763-5","article-title":"SAPS 3\u2014from evaluation of the patient to evaluation of the intensive care unit. Part 2: development of a prognostic model for hospital mortality at ICU admission","volume":"31","author":"Moreno","year":"2005","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib16","article-title":"the Portuguese Community-Acquired Sepsis Study Group (SACiUCI). C-reactive protein, an early marker of community-acquired sepsis resolution: a multi-center prospective observational study","volume":"15","author":"P\u00f3voa","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib17","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1038\/s41467-022-32222-2","article-title":"Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations","volume":"13","author":"Foy","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.bja.2025.10.048_bib18","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.bja.2025.10.048_bib19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0165025409343765","article-title":"Growth mixture modeling: a method for identifying differences in longitudinal change among unobserved groups","volume":"33","author":"Ram","year":"2009","journal-title":"Int J Behav Dev"},{"key":"10.1016\/j.bja.2025.10.048_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.alcr.2019.100323","article-title":"An overview of mixture modelling for latent evolutions in longitudinal data: modelling approaches, fit statistics and software","volume":"43","author":"van der Nest","year":"2020","journal-title":"Adv Life Course Res"},{"key":"10.1016\/j.bja.2025.10.048_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v078.i02","article-title":"Estimation of extended mixed models using latent classes and latent processes: the R Package lcmm","volume":"78","author":"Proust-Lima","year":"2017","journal-title":"J Stat Softw"},{"key":"10.1016\/j.bja.2025.10.048_bib22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13054-016-1355-9","article-title":"The Dose Response Multicentre Investigation on Fluid Assessment (DoReMIFA) in critically ill patients","volume":"20","author":"Garzotto","year":"2016","journal-title":"Crit Care Lond Engl"},{"key":"10.1016\/j.bja.2025.10.048_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/CCM.0000000000002189","article-title":"Higher fluid balance increases the risk of death from sepsis: results from a large international audit","volume":"45","author":"Sakr","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib24","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1097\/CCM.0000000000004617","article-title":"Fluid overload and mortality in adult critical care patients \u2013 a systematic review and meta-analysis of observational studies","volume":"48","author":"Messmer","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jcrc.2019.09.025","article-title":"Association of negative fluid balance during the de-escalation phase of sepsis management with mortality: a cohort study","volume":"55","author":"Dhondup","year":"2020","journal-title":"J Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib26","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1097\/CCM.0000000000003276","article-title":"Deresuscitation of patients with iatrogenic fluid overload is associated with reduced mortality in critical illness","volume":"46","author":"Silversides","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13054-022-04173-z","article-title":"Effective hemodynamic monitoring","volume":"26","author":"Pinsky","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13054-025-05490-9","article-title":"Can we reliably use pulse pressure as a surrogate for stroke volume? Physiological background and potential clinical implications for shock resuscitation","volume":"29","author":"Putowski","year":"2025","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00134-018-5147-3","article-title":"Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population","volume":"44","author":"Van Regenmortel","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2022.154169","article-title":"Perfusion-based deresuscitation during continuous renal replacement therapy: a before-after pilot study (The early dry Cohort)","volume":"72","author":"Ruste","year":"2022","journal-title":"J Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13054-025-05447-y","article-title":"Trajectories of fluid management after the initiation of renal replacement therapy in critically ill patients: a secondary analysis of the STARRT-AKI trial","volume":"29","author":"Beaubien-Souligny","year":"2025","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-021-03509-5","article-title":"Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study","volume":"25","author":"Cinotti","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.bja.2025.10.048_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13054-020-2795-9","article-title":"Impact of protocolized diuresis for de-resuscitation in the intensive care unit","volume":"24","author":"Bissell","year":"2020","journal-title":"Crit Care Lond Engl"},{"key":"10.1016\/j.bja.2025.10.048_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101970","article-title":"Subphenotyping heterogeneous patients with chronic critical illness to guide individualised fluid balance treatment using machine learning: a retrospective cohort study","volume":"59","author":"Liu","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.bja.2025.10.048_bib35","doi-asserted-by":"crossref","first-page":"e581","DOI":"10.1097\/CCM.0000000000005517","article-title":"Systematic review and comparison of publicly available ICU data sets \u2013 a decision guide for clinicians and data scientists","volume":"50","author":"Sauer","year":"2022","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bja.2025.10.048_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bja.2023.10.033","article-title":"The microcirculation in perioperative medicine: a narrative review","volume":"132","author":"Flick","year":"2024","journal-title":"Br J Anaesth"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225007883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225007883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:43:07Z","timestamp":1779813787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225007883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0007091225007883"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.10.048","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.10.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}]}}