{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:24:11Z","timestamp":1780478651346,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bjanaesthesia.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bja.2025.11.015","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T20:23:47Z","timestamp":1765830227000},"page":"491-494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Beyond activated partial thromboplastin time: viscoelastic monitoring of argatroban in the critically ill"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-0544","authenticated-orcid":false,"given":"Johannes","family":"Gratz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-6659","authenticated-orcid":false,"given":"Marion","family":"Wiegele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-8680","authenticated-orcid":false,"given":"Eva","family":"Schaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bja.2025.11.015_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.bja.2025.08.065","article-title":"Ecarin-based coagulation monitoring of argatroban in patients with heparin-induced thrombocytopenia: a prospective observational study","volume":"136","author":"Schiferer","year":"2026","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.11.015_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/ALN.0000000000004787","article-title":"Monitoring of argatroban in critically ill patients: a prospective study comparing activated partial thromboplastin time, point-of-care viscoelastic testing with ecarin clotting time and diluted thrombin time to mass spectrometry","volume":"140","author":"Heubner","year":"2024","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bja.2025.11.015_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.thromres.2017.07.006","article-title":"Should we abandon the APTT for monitoring unfractionated heparin?","volume":"157","author":"Arachchillage","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.bja.2025.11.015_bib4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.bja.2025.07.060","article-title":"Anticoagulation during extracorporeal membrane oxygenation: questioning the current standards in balancing the risks of thrombosis and bleeding","volume":"135","author":"Gratz","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.11.015_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMcp1411910","article-title":"Heparin-induced thrombocytopenia","volume":"373","author":"Greinacher","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.11.015_bib6","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/ajcp\/36.3.212","article-title":"The partial thromboplastin time with kaolin: a simple screening test for first stage plasma clotting factor deficiencies","volume":"36","author":"Proctor","year":"1961","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.bja.2025.11.015_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1056\/NEJM197208172870703","article-title":"A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time","volume":"287","author":"Basu","year":"1972","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.11.015_bib8","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJMra2104091","article-title":"Heparin resistance \u2014 clinical perspectives and management strategies","volume":"385","author":"Levy","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bja.2025.11.015_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11239-019-01879-w","article-title":"Influence of factor XII deficiency on activated partial thromboplastin time (aPTT) in critically ill patients","volume":"48","author":"Bachler","year":"2019","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.bja.2025.11.015_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MBC.0000000000000837","article-title":"Prolonged activated partial thromboplastin time due to plasma prekallikrein deficiency","volume":"30","author":"Zhou","year":"2019","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.bja.2025.11.015_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/0310057X1604400113","article-title":"Discordance between ROTEM\u00ae clotting time and conventional tests during unfractionated heparin\u2013based anticoagulation in intensive care patients on extracorporeal membrane oxygenation","volume":"44","author":"Prakash","year":"2016","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.bja.2025.11.015_bib12","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1182\/bloodadvances.2018024489","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia","volume":"2","author":"Cuker","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.bja.2025.11.015_bib13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00134-023-07103-x","article-title":"Resistance to unfractionated heparin in the ICU: evaluation and management options","volume":"49","author":"Levy","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bja.2025.11.015_bib14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/jcm9040963","article-title":"A prospective pilot trial to assess the efficacy of argatroban (Argatra\u00ae) in critically ill patients with heparin resistance","volume":"9","author":"Bachler","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.bja.2025.11.015_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-81396-w","article-title":"Detection of enoxaparin and argatroban by use of the novel viscoelastic coagulometer ClotPro","volume":"14","author":"Gratz","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.bja.2025.11.015_bib17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/anae.15254","article-title":"A prospective observational study of the rapid detection of clinically-relevant plasma direct oral anticoagulant levels following acute traumatic injury","volume":"76","author":"Oberladst\u00e4tter","year":"2021","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bja.2025.11.015_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12959-021-00267-w","article-title":"Viscoelastometry for detecting oral anticoagulants","volume":"19","author":"Groene","year":"2021","journal-title":"Thromb J"},{"key":"10.1016\/j.bja.2025.11.015_bib19","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/jth.13857","article-title":"Comparison of the ecarin chromogenic assay and diluted thrombin time for quantification of dabigatran concentrations","volume":"15","author":"Jaffer","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.bja.2025.11.015_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bja.2024.04.016","article-title":"Clinical practice, research, and collaboration with industry: impact of the discontinuation of a critical device","volume":"133","author":"Fries","year":"2024","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.11.015_bib21","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bja.2024.10.047","article-title":"Altered thrombin generation with prothrombin complex concentrate is not detected by viscoelastic testing: an in vitro study","volume":"134","author":"Hofmann","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bja.2025.11.015_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/ALN.0000000000004814","article-title":"Monitoring argatroban anticoagulation in the critically ill: all tests are not created equal","volume":"140","author":"Erdoes","year":"2024","journal-title":"Anesthesiology"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225008141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091225008141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:41:52Z","timestamp":1779813712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091225008141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0007091225008141"],"URL":"https:\/\/doi.org\/10.1016\/j.bja.2025.11.015","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond activated partial thromboplastin time: viscoelastic monitoring of argatroban in the critically ill","name":"articletitle","label":"Article Title"},{"value":"British Journal of Anaesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bja.2025.08.065","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}