{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:45:18Z","timestamp":1790635518827,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["bjaed.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BJA Education"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bjae.2024.10.007","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T01:32:09Z","timestamp":1736040729000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Haemophagocytic lymphohistiocytosis in critical care"],"prefix":"10.1016","volume":"25","author":[{"given":"K.","family":"Bauchm\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Manson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.S.","family":"Tattersall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjae.2024.10.007_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/1751143719893865","article-title":"Haemophagocytic lymphohistiocytosis in adult critical care","volume":"21","author":"Bauchmuller","year":"2020","journal-title":"J\u00a0Intensive Care Soc"},{"key":"10.1016\/j.bjae.2024.10.007_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13045-023-01434-4","article-title":"1-year survival in haemophagocytic lymphohistiocytosis: a nationwide cohort study from England 2003-2018","volume":"16","author":"West","year":"2023","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.bjae.2024.10.007_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12969-019-0309-6","article-title":"Calm in the\u00a0midst of cytokine storm: a collaborative approach to\u00a0the\u00a0diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome","volume":"17","author":"Halyabar","year":"2019","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.bjae.2024.10.007_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/rheumatology\/key006","article-title":"Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment","volume":"58","author":"Carter","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.bjae.2024.10.007_bib5","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1182\/blood.2018894618","article-title":"Recommendations for the management of hemophagocytic lymphohistiocytosis in adults","volume":"133","author":"La Rosee","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.bjae.2024.10.007_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/gene.2012.3","article-title":"Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment","volume":"13","author":"Ravelli","year":"2012","journal-title":"Genes Immun"},{"key":"10.1016\/j.bjae.2024.10.007_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12916-017-0930-5","article-title":"Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis","volume":"15","author":"Kyriazopoulou","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.bjae.2024.10.007_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2017.03.023","article-title":"Similar but not the same: differential diagnosis of HLH and sepsis","volume":"114","author":"Machowicz","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.bjae.2024.10.007_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/rheumatology\/kez379","article-title":"Haemophagocytic lymphohisticytosis-an underrecognized hyperinflammatory syndrome","volume":"58","author":"Hutchinson","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.bjae.2024.10.007_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/joim.13432","article-title":"Incidence and survival of haemophagocytic lymphohistiocytosis: a population-based cohort study from England","volume":"291","author":"West","year":"2022","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.bjae.2024.10.007_bib11","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","article-title":"Adult haemophagocytic syndrome","volume":"383","author":"Ramos-Casals","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bjae.2024.10.007_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2665-9913(23)00273-4","article-title":"Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH across Speciality Collaboration (HiHASC) consensus guideline","volume":"6","author":"Cox","year":"2024","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.bjae.2024.10.007_bib13","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1002\/cncr.30826","article-title":"A\u00a0consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults","volume":"123","author":"Daver","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.bjae.2024.10.007_bib14","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bjae.2024.10.007_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bjae.2022.04.001","article-title":"Chimeric antigen receptor T-cell therapy in adults: management of toxicities and implications for critical care","volume":"22","author":"Haseeb","year":"2022","journal-title":"BJA Educ"},{"key":"10.1016\/j.bjae.2024.10.007_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/pbc.22774","article-title":"Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality","volume":"56","author":"Lin","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bjae.2024.10.007_bib17","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/01.CCM.0000127779.24232.15","article-title":"Multifactorial risk analysis of bone\u00a0marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients\u2013a postmortem clinicopathologic analysis","volume":"32","author":"Strauss","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bjae.2024.10.007_bib18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bjae.2024.10.007_bib19","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/ard-2023-224123","article-title":"HLH\/MAS task force. The 2022 EULAR\/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis\/macrophage activation syndrome (HLH\/MAS)","volume":"82","author":"Shakoory","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bjae.2024.10.007_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bjae.2024.10.007_bib21","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.bjae.2024.10.007_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13054-020-02941-3","article-title":"Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore","volume":"24","author":"Knaak","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.bjae.2024.10.007_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/0885066617711386","article-title":"Interleukin 1 receptor antagonist anakinra, intravenous immunoglobulin, and corticosteroids in the management of critically ill adult patients with hemophagocytic lymphohistiocytosis","volume":"34","author":"Wohlfarth","year":"2019","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.bjae.2024.10.007_bib24","first-page":"1033","article-title":"Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.bjae.2024.10.007_bib25","doi-asserted-by":"crossref","first-page":"e630","DOI":"10.1016\/S2352-3026(19)30156-5","article-title":"Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial","volume":"6","author":"Ahmed","year":"2019","journal-title":"Lancet Haematol"}],"container-title":["BJA Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2058534924001264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2058534924001264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:09:42Z","timestamp":1772327382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2058534924001264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2058534924001264"],"URL":"https:\/\/doi.org\/10.1016\/j.bjae.2024.10.007","relation":{},"ISSN":["2058-5349"],"issn-type":[{"value":"2058-5349","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haemophagocytic lymphohistiocytosis in critical care","name":"articletitle","label":"Article Title"},{"value":"BJA Education","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjae.2024.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}