{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:13:23Z","timestamp":1788236003898,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-EURE-022"],"award-info":[{"award-number":["ANR-17-EURE-022"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjaed.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BJA Education"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bjae.2025.04.008","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:29:08Z","timestamp":1748935748000},"page":"357-366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurophysiology of acute and chronic pain: from genes to pain symptoms"],"prefix":"10.1016","volume":"25","author":[{"given":"P.","family":"Poisbeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Salvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjae.2025.04.008_bib1","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/ejp.2232","article-title":"Anxiety, history of childhood adversity, and experiencing chronic pain in adulthood: a systematic literature review and meta-analysis","volume":"28","author":"Dalechek","year":"2024","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2401331121","article-title":"Sex bias in pain management decisions","volume":"121","author":"Guzikevits","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bjae.2025.04.008_bib5","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1073\/pnas.1516047113","article-title":"Racial bias in pain assessment and treatment recommendations, and false beliefs about biological differences between blacks and whites","volume":"113","author":"Hoffman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bjae.2025.04.008_bib6","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1097\/j.pain.0000000000001340","article-title":"Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy","volume":"159","author":"Finnerup","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41583-021-00536-7","article-title":"Innovations and advances in modelling and measuring pain in animals","volume":"23","author":"Sadler","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bjae.2025.04.008_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1533-2500.2005.05203.x","article-title":"Evolution of the neuromatrix theory of pain. The Prithvi Raj lecture: presented at the third world congress of world institute of pain, Barcelona 2004","volume":"5","author":"Melzack","year":"2005","journal-title":"Pain Pract"},{"key":"10.1016\/j.bjae.2025.04.008_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0166-2236(03)00123-1","article-title":"A new view of pain as a homeostatic emotion","volume":"26","author":"Craig","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.bjae.2025.04.008_bib10","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1002\/hbm.23310","article-title":"Pain networks from the inside: spatiotemporal analysis of brain responses leading from nociception to conscious perception","volume":"37","author":"Bastuji","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bjae.2025.04.008_bib11","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1152\/jn.1999.82.4.1934","article-title":"Pain intensity processing within the human brain: a bilateral, distributed mechanism","volume":"82","author":"Coghill","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bjae.2025.04.008_bib12","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa1204471","article-title":"An fMRI-based neurologic signature of physical pain","volume":"368","author":"Wager","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjae.2025.04.008_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pneurobio.2010.10.005","article-title":"The pain matrix reloaded: a salience detection system for the body","volume":"93","author":"Legrain","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bjae.2025.04.008_bib14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3166\/dea-2020-0077","article-title":"Cone snails, a natural resource of analgesics from the bottom of the sea: beyond the ziconotide?","volume":"32","author":"Gier\u00e9","year":"2019","journal-title":"Douleur Analg"},{"key":"10.1016\/j.bjae.2025.04.008_bib15","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1097\/j.pain.0000000000003204","article-title":"Peripheral and central neurobiological effects of botulinum toxin A (BoNT\/A) in neuropathic pain: a systematic review","volume":"165","author":"Moreau","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0306-4522(99)00461-3","article-title":"Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonist","volume":"95","author":"Ishikawa","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.bjae.2025.04.008_bib17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pain.2008.06.016","article-title":"Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms","volume":"139","author":"Charlet","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib18","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central Sensitisation: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","article-title":"The induction of pain: an integrative review","volume":"57","author":"Millan","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bjae.2025.04.008_bib20","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bjae.2025.04.008_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-med-052209-100430","article-title":"Stress- and allostasis-induced brain plasticity","volume":"62","author":"McEwen","year":"2011","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.bjae.2025.04.008_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108032","article-title":"Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization","volume":"233","author":"Gerum","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bjae.2025.04.008_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00001756-200301200-00001","article-title":"Opioid-induced hyperalgesia: abnormal or normal pain?","volume":"14","author":"Simonnet","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.bjae.2025.04.008_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.bjae.2024.07.004","article-title":"The genetics of pain","volume":"24","author":"Cox","year":"2024","journal-title":"BJA Educ"},{"key":"10.1016\/j.bjae.2025.04.008_bib25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrg2322","article-title":"Heritability in the genomics era--concepts and misconceptions","volume":"9","author":"Visscher","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bjae.2025.04.008_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0304-3959(87)90080-7","article-title":"Pain and families. I. Etiology, maintenance, and psychosocial impact","volume":"30","author":"Turk","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ng.3285","article-title":"Meta-analysis of the heritability of human traits based on fifty years of twin studies","volume":"47","author":"Polderman","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.bjae.2025.04.008_bib28","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/j.1532-2149.2011.00095.x","article-title":"Heritability of chronic pain in 2195 extended families","volume":"16","author":"Hocking","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib29","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/brain\/awab359","article-title":"Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions","volume":"145","author":"Khoury","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.bjae.2025.04.008_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41572-022-00365-7","article-title":"Genetic pain loss disorders","volume":"8","author":"Lischka","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.bjae.2025.04.008_bib31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tig.2012.02.004","article-title":"Pain genetics: past, present and future","volume":"28","author":"Mogil","year":"2012","journal-title":"Trends Genet"},{"key":"10.1016\/j.bjae.2025.04.008_bib32","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/j.pain.0000000000001135","article-title":"Human pain genetics database: a resource dedicated to human pain genetics research","volume":"159","author":"Meloto","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib33","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/j.pain.0000000000002910","article-title":"A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses","volume":"164","author":"Li","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.bjae.2025.04.008_bib34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1146\/annurev.neuro.24.1.1161","article-title":"Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations","volume":"24","author":"Meaney","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.bjae.2025.04.008_bib35","first-page":"250","article-title":"The epigenetic scars of our life experiences with acute and chronic pain","volume":"36","author":"Baire","year":"2023","journal-title":"Douleur Analg"},{"key":"10.1016\/j.bjae.2025.04.008_bib36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/jn.00751.2010","article-title":"Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission","volume":"106","author":"Nelson","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bjae.2025.04.008_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13148-023-01569-8","article-title":"A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain","volume":"15","author":"Maiar\u00f9","year":"2023","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.bjae.2025.04.008_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2217\/epi.15.78","article-title":"Methadone induces hypermethylation of human DNA","volume":"8","author":"Knothe","year":"2016","journal-title":"Epigenomics"},{"key":"10.1016\/j.bjae.2025.04.008_bib39","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2119\/molmed.2011.00030","article-title":"HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritis","volume":"17","author":"Vojinovic","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.bjae.2025.04.008_bib40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/cncr.25584","article-title":"Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma","volume":"117","author":"Niesvizky","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.bjae.2025.04.008_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-9-195","article-title":"MicroRNA modulation in complex regional pain syndrome","volume":"9","author":"Orlova","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.bjae.2025.04.008_bib42","article-title":"Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients","volume":"96","author":"Huang","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.bjae.2025.04.008_bib43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.expneurol.2016.06.025","article-title":"Increased miR-132-3p expression is associated with chronic neuropathic pain","volume":"283","author":"Leinders","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjae.2025.04.008_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078762","article-title":"Profile of cerebrospinal microRNAs in fibromyalgia","volume":"8","author":"Bjersing","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bjae.2025.04.008_bib45","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2015.11.102","article-title":"MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome","volume":"469","author":"Liao","year":"2016","journal-title":"Biochem Biophys Res Commun"}],"container-title":["BJA Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2058534925000472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2058534925000472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:16:37Z","timestamp":1788232597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2058534925000472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2058534925000472"],"URL":"https:\/\/doi.org\/10.1016\/j.bjae.2025.04.008","relation":{},"ISSN":["2058-5349"],"issn-type":[{"value":"2058-5349","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurophysiology of acute and chronic pain: from genes to pain symptoms","name":"articletitle","label":"Article Title"},{"value":"BJA Education","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjae.2025.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Journal of Anaesthesia. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}