{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T02:10:31Z","timestamp":1758593431337,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bjan.2020.08.006","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T18:25:06Z","timestamp":1603391106000},"page":"605-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efeito da pr\u00e9\u2010administra\u00e7\u00e3o de flurbiprofeno axetil na CE50 do propofol durante anestesia em pacientes n\u00e3o estimulados: estudo cl\u00ednico randomizado"],"prefix":"10.1016","volume":"70","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mian","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong\u2010Ze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-6536","authenticated-orcid":false,"given":"Yan\u2010Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjan.2020.08.006_bib0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(97)00120-6","article-title":"Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)\u2010flurbiprofen following extraction of impacted third molars","volume":"73","author":"Roszkowski","year":"1997","journal-title":"Pain."},{"key":"10.1016\/j.bjan.2020.08.006_bib0160","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1007\/s00540-017-2409-0","article-title":"Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta\u2010analysis of randomized controlled trials","volume":"31","author":"Wang","year":"2017","journal-title":"J Anesth."},{"key":"10.1016\/j.bjan.2020.08.006_bib0165","doi-asserted-by":"crossref","first-page":"e9911","DOI":"10.1097\/MD.0000000000009911","article-title":"Effect of oxycodone hydrochloride combined with flurbiprofen axetil for intravenous patient\u2010controlled analgesia in lower abdominal patients: A randomized trial","volume":"97","author":"Xiang","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.bjan.2020.08.006_bib0170","first-page":"3942040","article-title":"Effect of preemptive flurbiprofen axetil and tramadol on transurethral resection of the prostate under spinal anesthesia","volume":"2016","author":"Wang","year":"2016","journal-title":"Pain Res Treat."},{"key":"10.1016\/j.bjan.2020.08.006_bib0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jocn.12258","article-title":"Facilitating early recovery of bowel motility after colorectal surgery: a systematic review","volume":"23","author":"Wallstrom","year":"2014","journal-title":"J Clin Nurs."},{"key":"10.1016\/j.bjan.2020.08.006_bib0180","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/BF03016307","article-title":"Intravenous flurbiprofen axetil accelerates restoration of bowel function after colorectal surgery","volume":"55","author":"Xu","year":"2008","journal-title":"Can J Anaesth."},{"key":"10.1016\/j.bjan.2020.08.006_bib0185","doi-asserted-by":"crossref","first-page":"995","DOI":"10.12659\/MSM.890102","article-title":"Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta\u2010analysis","volume":"20","author":"Zhang","year":"2014","journal-title":"Med Sci Monit."},{"key":"10.1016\/j.bjan.2020.08.006_bib0190","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00540-007-0530-1","article-title":"Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration","volume":"21","author":"Ueki","year":"2007","journal-title":"J Anesth."},{"key":"10.1016\/j.bjan.2020.08.006_bib0195","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/BF01966467","article-title":"Effects of pentazocine and acetylsalicylic acid on pain\u2010rating, pain\u2010related evoked potentials and vigilance in relationship to pharmacokinetic parameters","volume":"29","author":"Kobal","year":"1990","journal-title":"Agents Actions."},{"key":"10.1016\/j.bjan.2020.08.006_bib0200","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2125.1995.tb05799.x","article-title":"Effects of azapropazone on pain\u2010related brain activity in human subjects","volume":"40","author":"Lotsch","year":"1995","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0205","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/sleep\/12.6.516","article-title":"Aspirin and nonfebrile waking oral temperature in healthy men and women: links with SWS changes?","volume":"12","author":"Horne","year":"1989","journal-title":"Sleep."},{"key":"10.1016\/j.bjan.2020.08.006_bib0210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-2999(85)90757-5","article-title":"Differential effects of prostaglandin synthetase inhibitors on EEG in rat","volume":"111","author":"Wallenstein","year":"1985","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0215","doi-asserted-by":"crossref","first-page":"601083","DOI":"10.1155\/2015\/601083","article-title":"Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery","volume":"2015","author":"Geng","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bjan.2020.08.006_bib0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12871-015-0141-6","article-title":"Target\u2010controlled infusion of remifentanil with or without flurbiprofen axetil in sedation for extracorporeal shock wave lithotripsy of pancreatic stones: a prospective, open\u2010label, randomized controlled trial","volume":"15","author":"Yang","year":"2015","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0225","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/00000542-200111000-00019","article-title":"Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol","volume":"95","author":"Ibrahim","year":"2001","journal-title":"Anesthesiology."},{"key":"10.1016\/j.bjan.2020.08.006_bib0230","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/00000542-199704000-00014","article-title":"Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers","volume":"86","author":"Glass","year":"1997","journal-title":"Anesthesiology."},{"key":"10.1016\/j.bjan.2020.08.006_bib0235","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0149-7634(05)80090-9","article-title":"Staircase bioassay: the up\u2010and\u2010down method","volume":"15","author":"Dixon","year":"1991","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.bjan.2020.08.006_bib0240","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1213\/01.ane.0000252966.03103.89","article-title":"Low and moderate remifentanil infusion rates do not alter target\u2010controlled infusion propofol concentrations necessary to maintain anesthesia as assessed by bispectral index monitoring","volume":"104","author":"Wang","year":"2007","journal-title":"Anesth Analg."},{"key":"10.1016\/j.bjan.2020.08.006_bib0245","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12688\/f1000research.12502.1","article-title":"Recent progress on the molecular pharmacology of propofol","volume":"7","author":"Tang","year":"2018","journal-title":"F1000Res."},{"key":"10.1016\/j.bjan.2020.08.006_bib0250","first-page":"5","article-title":"Acute inflammation reveals GABAA receptor\u2010mediated nociception in mouse dorsal root ganglion neurons via PGE2 receptor 4 signaling","author":"Jang","year":"2017","journal-title":"Physiol Rep."},{"key":"10.1016\/j.bjan.2020.08.006_bib0255","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1073\/pnas.1618144114","article-title":"Identification of a putative binding site critical for general anesthetic activation of TRPA1","volume":"114","author":"Ton","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.bjan.2020.08.006_bib0260","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.bpj.2017.08.040","article-title":"Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling","volume":"113","author":"Woll","year":"2017","journal-title":"Biophys J."},{"key":"10.1016\/j.bjan.2020.08.006_bib0265","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00424-009-0749-9","article-title":"Activation of TRPA1 channels by fenamate nonsteroidal anti\u2010inflammatory drugs","volume":"459","author":"Hu","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bjan.2020.08.006_bib0270","first-page":"18","article-title":"Clinical Pharmacokinetics and Pharmacodynamics of Propofol","author":"Sahinovic","year":"2018","journal-title":"Clin Pharmacokinet."},{"key":"10.1016\/j.bjan.2020.08.006_bib0275","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1211\/jpp.60.1.0002","article-title":"Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats","volume":"60","author":"Ogata","year":"2008","journal-title":"J Pharm Pharmacol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0280","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2125.1999.00860.x","article-title":"Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics","volume":"47","author":"Mazoit","year":"1999","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0285","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1365-2125.1989.tb03451.x","article-title":"Differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans","volume":"27","author":"Sweeney","year":"1989","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.bjan.2020.08.006_bib0290","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.12659\/MSM.910103","article-title":"Pharmacokinetic Analysis of Propofol Target\u2010Controlled Infusion Models in Chinese Patients with Hepatic Insufficiency","volume":"24","author":"Chi","year":"2018","journal-title":"Med Sci Monit."},{"key":"10.1016\/j.bjan.2020.08.006_bib0295","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1631\/jzus.2005.B0043","article-title":"Predictive performance of \u2018Diprifusor\u2019 T.C.I. system in patients during upper abdominal surgery under propofol\/fentanyl anesthesia","volume":"6","author":"Li","year":"2005","journal-title":"Zhejiang Univ Sci J.B."},{"key":"10.1016\/j.bjan.2020.08.006_bib0300","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bjan.2016.02.010","article-title":"A comparative study between propofol and etomidate in patients under general anesthesia","volume":"66","author":"Aggarwal","year":"2016","journal-title":"Rev Bras Anestesiol."}],"container-title":["Brazilian Journal of Anesthesiology"],"original-title":[],"language":"pt","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034709420304335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034709420304335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T05:19:38Z","timestamp":1758518378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034709420304335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0034709420304335"],"URL":"https:\/\/doi.org\/10.1016\/j.bjan.2020.08.006","relation":{},"ISSN":["0034-7094"],"issn-type":[{"type":"print","value":"0034-7094"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efeito da pr\u00e9\u2010administra\u00e7\u00e3o de flurbiprofeno axetil na CE50 do propofol durante anestesia em pacientes n\u00e3o estimulados: estudo cl\u00ednico randomizado","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjan.2020.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2020.10.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia.","name":"copyright","label":"Copyright"}]}}