{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:16:52Z","timestamp":1773357412307,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bjane.2014.06.006","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T03:45:51Z","timestamp":1413431151000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Local analgesic effect of tramadol is not mediated by opioid receptors in early postoperative pain in rats"],"prefix":"10.1016","volume":"65","author":[{"given":"Angela Maria","family":"Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem Adel","family":"Ashmawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.bjane.2014.06.006_bib0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2165\/00003495-199700532-00006","article-title":"Pharmacologie du tramadol","author":"Dayer","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.bjane.2014.06.006_bib0010","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/ajhp\/54.6.643","article-title":"Tramadol: a new centrally acting analgesic","volume":"54","author":"Lewis","year":"1997","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.bjane.2014.06.006_bib0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3565(25)11227-5","article-title":"Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an \u2018atypical\u2019 opioid analgesic","volume":"260","author":"Raffa","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bjane.2014.06.006_bib0020","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1097\/00000539-200106000-00040","article-title":"Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked potentials in rats","volume":"92","author":"Tsai","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2014.06.006_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pain.2006.07.003","article-title":"Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels","volume":"126","author":"Haeseler","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1590\/S0100-879X2011007500164","article-title":"Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models","volume":"45","author":"Sousa","year":"2012","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.bjane.2014.06.006_bib0035","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.joms.2013.08.009","article-title":"Comparison of local anesthetic efficacy of tramadol hydrochloride (with adrenaline) versus plain tramadol hydrochloride in the extraction of upper molar teeth","volume":"71","author":"Al-Haideri","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjane.2014.06.006_bib0040","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jpurol.2012.07.022","article-title":"Comparison of local anesthetic effects of lidocaine versus tramadol and effect of child anxiety on pain level in circumcision procedure","volume":"9","author":"Polat","year":"2013","journal-title":"J Pediatr Urol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0045","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.urology.2009.06.108","article-title":"Comparison of local anesthetic effects of tramadol with prilocaine during circumcision procedure","volume":"75","author":"Kargi","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.bjane.2014.06.006_bib0050","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/bja\/ael155","article-title":"Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy","volume":"97","author":"Prakash","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjane.2014.06.006_bib0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1213\/ane.0b013e31818e0c6b","article-title":"Tramadol as an adjuvant to lidocaine for axillary brachial plexus block","volume":"108","author":"Kaabachi","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2014.06.006_bib0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00540-012-1510-7","article-title":"Tramadol and levobupivacaine wound infiltration at Cesarean delivery for postoperative analgesia","volume":"27","author":"Demiraran","year":"2013","journal-title":"J Anesth"},{"key":"10.1016\/j.bjane.2014.06.006_bib0065","doi-asserted-by":"crossref","first-page":"237S","DOI":"10.1111\/j.1365-2125.1980.tb01806.x","article-title":"Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists","volume":"10","author":"Ferreira","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00006396-199706000-00001","article-title":"Peripheral morphine analgesia","volume":"71","author":"Stein","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1744-8069-7-25","article-title":"Peripheral effects of morphine and expression of \u03bc-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling","volume":"7","author":"Hervera","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0080","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroscience.2011.05.062","article-title":"Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats","volume":"190","author":"Saloman","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bjane.2014.06.006_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neulet.2012.07.018","article-title":"Effects of peripheral \u03ba opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats","volume":"524","author":"Auh","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bjane.2014.06.006_bib0090","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/j.1532-2149.2011.00070.x","article-title":"Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids","volume":"16","author":"Khalefa","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0095","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/j.1532-2149.2012.00242.x","article-title":"Involvement of peripheral cannabinoid and opioid receptors in \u03b2-caryophyllene-induced antinociception","volume":"17","author":"Katsuyama","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0100","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1213\/00000539-199706000-00025","article-title":"Intraarticular morphine analgesia in chronic pain patients with osteoarthritis","volume":"84","author":"Likar","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2014.06.006_bib0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0304-3959(95)01441-1","article-title":"Characterization of a rat model of incisional pain","volume":"64","author":"Brennan","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bjane.2014.06.006_bib0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2010.07.015","article-title":"The necessity of animal models in pain research","volume":"151","author":"Mogil","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bjane.2014.06.006_bib0125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/ACO.0b013e3282ef6b2c","article-title":"Genetic factors in pain and its treatment","volume":"20","author":"Stamer","year":"2007","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0130","series-title":"Conf\u00e9rences d\u2019Actualisation","first-page":"715","article-title":"Tramadol et prise en charge de la douleur","author":"Gentilli","year":"2004"},{"key":"10.1016\/j.bjane.2014.06.006_bib0135","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1213\/ANE.0b013e31825683c3","article-title":"Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain","volume":"115","author":"Kimura","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2014.06.006_bib0140","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1523\/JNEUROSCI.15-12-08156.1995","article-title":"Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan induced inflammation","volume":"15","author":"Ji","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjane.2014.06.006_bib0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-2999(02)01368-7","article-title":"Comparison of nerve conduction blocks by an opioid and a local anesthetic","volume":"439","author":"Mert","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2006.06.008","article-title":"Comparative effects of lidocaine and tramadol on injured peripheral nerves","volume":"543","author":"Mert","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0155","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1472-8206.1999.tb00342.x","article-title":"Effects of tramadol on experimental inflammation","volume":"13","author":"Bianchi","year":"1999","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0160","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2006.11.055","article-title":"Local analgesic efficacy of tramadol following intraplantar injection","volume":"858","author":"Mert","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bjane.2014.06.006_bib0165","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1213\/ane.0b013e318172fefc","article-title":"The analgesic drug, tramadol. Acts as an agonist of the transient receptor potential vanilloid-1","volume":"106","author":"Marincs\u00e1k","year":"2008","journal-title":"Anesth Analg"}],"container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001414001705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001414001705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:50:28Z","timestamp":1746420628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0104001414001705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0104001414001705"],"URL":"https:\/\/doi.org\/10.1016\/j.bjane.2014.06.006","relation":{},"ISSN":["0104-0014"],"issn-type":[{"value":"0104-0014","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local analgesic effect of tramadol is not mediated by opioid receptors in early postoperative pain in rats","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2014.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}