{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:23:56Z","timestamp":1790029436918,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bjane.2021.05.016","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:53:20Z","timestamp":1623239600000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-7572","authenticated-orcid":false,"given":"Daniella Aparecida Godoi","family":"Kemper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-3898","authenticated-orcid":false,"given":"Denise Aya","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-6627","authenticated-orcid":false,"given":"D..bora Rothstein Ramos","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8030-0609","authenticated-orcid":false,"given":"Cristina de Oliveira","family":"Mossoco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-5036","authenticated-orcid":false,"given":"Rog..rio Anderson","family":"Marcasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-2087","authenticated-orcid":false,"given":"Ligia Cristina C..mara","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-1743","authenticated-orcid":false,"suffix":"Jr.","given":"Jos.. Ot..vio Costa","family":"Auler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-2038","authenticated-orcid":false,"given":"Denise Tabacchi","family":"Fantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjane.2021.05.016_bib0005","first-page":"315801","article-title":"The Thrid International Consensus Definitions for Sepsis and Septic Shock (Sepsis -3)","author":"Singer","year":"2016","journal-title":"JAMA."},{"key":"10.1016\/j.bjane.2021.05.016_bib0010","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1378\/chest.73.5.583","article-title":"Pulmonary hypertension in sepsis: measurement by the pulmonary arterial diastolic-pulmonary wedge pressure gradient and the influence of passive and active factors","volume":"73","author":"Sibbald","year":"1978","journal-title":"Chest."},{"key":"10.1016\/j.bjane.2021.05.016_bib0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccm.2008.07.002","article-title":"The right ventricle in sepsis","volume":"29","author":"Chan","year":"2008","journal-title":"Clin Chest Med."},{"key":"10.1016\/j.bjane.2021.05.016_bib0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/jsre.1999.5748","article-title":"Platelet-activating factor and bacteremia-induced pulmonary hypertension","volume":"88","author":"Clavijo","year":"2000","journal-title":"J Surg Res."},{"key":"10.1016\/j.bjane.2021.05.016_bib0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1164\/ajrccm.163.2.2003021","article-title":"Sildenafil modulates hemodynamics and pulmonary gas exchange","volume":"163","author":"Kleinsasser","year":"2001","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.bjane.2021.05.016_bib0030","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1053\/j.jvca.2005.12.011","article-title":"Treatment of pulmonary arterial hypertension with sildenafil: from pathophysiology to clinical evidence","volume":"20","author":"Raja","year":"2006","journal-title":"J Cardiothorac Vasc Anesth."},{"key":"10.1016\/j.bjane.2021.05.016_bib0035","doi-asserted-by":"crossref","first-page":"R103","DOI":"10.1530\/EJE-14-0700","article-title":"Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis","volume":"172","author":"Santi","year":"2015","journal-title":"Eur J Endocrinol."},{"key":"10.1016\/j.bjane.2021.05.016_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126580","article-title":"Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice","volume":"10","author":"Venneri","year":"2015","journal-title":"PLoS One."},{"key":"10.1016\/j.bjane.2021.05.016_bib0045","doi-asserted-by":"crossref","first-page":"I20","DOI":"10.1002\/clc.4960271306","article-title":"Novel phosphodiesterase type 5 inhibitors: assessing hemodynamic effects and safety parameters","volume":"27","author":"Kloner","year":"2004","journal-title":"Clin Cardiol."},{"key":"10.1016\/j.bjane.2021.05.016_bib0050","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4065\/78.10.1207","article-title":"Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy","volume":"78","author":"Bhatia","year":"2003","journal-title":"Mayo Clin Proc."},{"key":"10.1016\/j.bjane.2021.05.016_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.resp.2015.04.003","article-title":"Effects of lipopolysaccharide-induced inflammation on initial lung fibrosis during open-lung mechanical ventilation in rats","volume":"212...214","author":"Krebs","year":"2015","journal-title":"Respir Physiol Neurobiol."},{"key":"10.1016\/j.bjane.2021.05.016_bib0060","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1365-2249.2011.04483.x","article-title":"Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study","volume":"166","author":"Cadirci","year":"2011","journal-title":"Clin Exp Immunol."},{"key":"10.1016\/j.bjane.2021.05.016_bib0065","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.shk.0000209529.43367.00","article-title":"Infusion of increasing doses of endotoxin induces progressive acute lung injury but prevents early pulmonary hypertension in pigs","volume":"25","author":"Schmidhammer","year":"2006","journal-title":"Shock."},{"key":"10.1016\/j.bjane.2021.05.016_bib0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/shk.0b013e318067dfbc","article-title":"Effect of the administration rate on the biological responses to a fixed dose of endotoxin in the anesthetized pig","volume":"29","author":"Lipcsey","year":"2008","journal-title":"Shock."},{"key":"10.1016\/j.bjane.2021.05.016_bib0075","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1399-6576.1987.tb02619.x","article-title":"Choice of anesthetic alters the circulatory shock pattern as gauged by conscious rat endotoxemia","volume":"31","author":"Schaefer","year":"1987","journal-title":"Acta Anaesthesiol Scand."},{"key":"10.1016\/j.bjane.2021.05.016_bib0080","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1399-6576.2011.02436.x","article-title":"No beneficial effects of levosimendan in acute porcine endotoxaemia","volume":"55","author":"Chew","year":"2011","journal-title":"Acta Anaesthesiol Scand."},{"key":"10.1016\/j.bjane.2021.05.016_bib0085","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0140-6736(07)60604-7","article-title":"Acute lung injury and the acute respiratory distress syndrome: a clinical review","volume":"369","author":"Wheeler","year":"2007","journal-title":"Lancet."},{"key":"10.1016\/j.bjane.2021.05.016_bib0090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000121471","article-title":"Overview of the pathology of three widely used animal models of acute lung injury","volume":"40","author":"Wang","year":"2008","journal-title":"Eur Surg Res."},{"key":"10.1016\/j.bjane.2021.05.016_bib0095","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccc.2010.01.001","article-title":"The role of echocardiography in hemodynamic assessment of septic shock","volume":"26","author":"Griffee","year":"2010","journal-title":"Crit Care Clin."},{"key":"10.1016\/j.bjane.2021.05.016_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2011.06.017","article-title":"Ventricular dysfunction and dilation in severe sepsis and septic shock: relation to endothelial function and mortality","volume":"27","author":"Furian","year":"2012","journal-title":"J Crit Care."},{"key":"10.1016\/j.bjane.2021.05.016_bib0105","doi-asserted-by":"crossref","first-page":"R149","DOI":"10.1186\/cc13987","article-title":"Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function","volume":"18","author":"Orde","year":"2014","journal-title":"Crit Care."},{"key":"10.1016\/j.bjane.2021.05.016_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2013.07.059","article-title":"Assessment of right ventricular functions in patients with sepsis, severe sepsis and septic shock and its prognostic importance: a tissue Doppler study","volume":"28","author":"Harmankaya","year":"2013","journal-title":"J Crit Care."},{"key":"10.1016\/j.bjane.2021.05.016_bib0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.shk.0000215321.44983.98","article-title":"Dose response of intravenous sildenafil on systemic and regional hemodynamics in hypoxic neonatal piglets","volume":"26","author":"Haase","year":"2006","journal-title":"Shock."},{"key":"10.1016\/j.bjane.2021.05.016_bib0120","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1203\/01.pdr.0000219501.58546.aa","article-title":"Effect of intravenous sildenafil on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung injury in piglets","volume":"59","author":"Ryhammer","year":"2006","journal-title":"Pediatr Res."},{"key":"10.1016\/j.bjane.2021.05.016_bib0125","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(02)11024-5","article-title":"Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial","volume":"360","author":"Ghofrani","year":"2002","journal-title":"Lancet."},{"key":"10.1016\/j.bjane.2021.05.016_bib0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cardfail.2013.12.001","article-title":"Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes","volume":"20","author":"Roy","year":"2014","journal-title":"J Card Fail."},{"key":"10.1016\/j.bjane.2021.05.016_bib0135","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1097\/01.CCM.0000281852.36573.22","article-title":"Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome","volume":"35","author":"Bajwa","year":"2007","journal-title":"Crit Care Med."},{"key":"10.1016\/j.bjane.2021.05.016_bib0140","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2210-5-10","article-title":"Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T","volume":"5","author":"Hassan","year":"2005","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.bjane.2021.05.016_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104890","article-title":"Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines\/chemokines, MAP kinases and Akt","volume":"9","author":"Kiss","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.bjane.2021.05.016_bib0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.103.061739","article-title":"A nitric oxide-releasing salbutamol elicits potent relaxant and anti-inflammatory activities","volume":"310","author":"Lagente","year":"2004","journal-title":"J Pharmacol Exp Ther."}],"container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001421002396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001421002396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:01:08Z","timestamp":1758830468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0104001421002396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0104001421002396"],"URL":"https:\/\/doi.org\/10.1016\/j.bjane.2021.05.016","relation":{},"ISSN":["0104-0014"],"issn-type":[{"value":"0104-0014","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2021.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia.","name":"copyright","label":"Copyright"}]}}