{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:23:34Z","timestamp":1758846214737,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bjane.2021.09.011","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T03:54:38Z","timestamp":1633492478000},"page":"744290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of exogenous opioids on the acute inflammatory response in the perioperative period of oncological surgery: a clinical study"],"prefix":"10.1016","volume":"74","author":[{"given":"Odirlei Jo.\u00b7o","family":"Titon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana Perotta","family":"Titon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana.\u00edna Carla da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane Okamoto","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Ricrado","family":"Garbim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jano..rio Athanazio de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-4369","authenticated-orcid":false,"given":"Carolina","family":"Panis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2014","series-title":"Protocolos Cl.\u00ednicos e Diretrizes Terap.\u00bcuticas em Oncologia","author":"Minist..rio da Sa..de (Brasil)","key":"10.1016\/j.bjane.2021.09.011_bib0005"},{"key":"10.1016\/j.bjane.2021.09.011_bib0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4103\/0973-1482.157321","article-title":"Anesthesia and cancer recurrences: the current knowledge and evidence","volume":"11","author":"Bajwa","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.bjane.2021.09.011_bib0015","first-page":"756","article-title":"Cancer Recurrence and Regional Anesthesia: The Theories, the Data, and the Future in Outcomes","volume":"17","author":"Le-Wendling","year":"2016","journal-title":"Pain Med"},{"key":"10.1016\/j.bjane.2021.09.011_bib0020","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/ijc.26448","article-title":"Cancer recurrence after surgery: direct and indirect effects of anesthetic agents","volume":"130","author":"Tavare","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bjane.2021.09.011_bib0025","doi-asserted-by":"crossref","first-page":"ii34","DOI":"10.1093\/bja\/aev375","article-title":"Regional anaesthesia and analgesia: relationship to cancer recurrence and survival","volume":"115","author":"Tedore","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjane.2021.09.011_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008877.pub2","article-title":"Anaesthetic techniques for risk of malignant tumour recurrence","author":"Cakmakkaya","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjane.2021.09.011_bib0035","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/cncr.29532","article-title":"Opioids and breast cancer recurrence: A Danish population-based cohort study","volume":"121","author":"Cronin-Fenton","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.bjane.2021.09.011_bib0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-018-1389-7","article-title":"Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence","volume":"16","author":"Kim","year":"2018","journal-title":"J Transl Med"},{"key":"10.1016\/j.bjane.2021.09.011_bib0045","first-page":"290","article-title":"Surgery for triple-negative breast cancer- does the type of anaesthesia have an influence on oxidative stress, inflammation, molecular regulators, and outcomes of disease?","volume":"23","author":"Lukoseviciene","year":"2018","journal-title":"J Buon"},{"key":"10.1016\/j.bjane.2021.09.011_bib0050","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000502107","article-title":"Morphine promotes the angiogenesis of postoperative recurrent tumors and metastasis of dormant breast cancer cells","volume":"104","author":"Cheng","year":"2019","journal-title":"Pharmacol"},{"key":"10.1016\/j.bjane.2021.09.011_bib0055","doi-asserted-by":"crossref","first-page":"i4","DOI":"10.1093\/bja\/aeu090","article-title":"Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer","volume":"113","author":"Nguyen","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjane.2021.09.011_bib0060","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10555-011-9285-0","article-title":"Morphine and tumor growth and metastasis","volume":"30","author":"Afsharimani","year":"2011","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.bjane.2021.09.011_bib0065","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1213\/ANE.0000000000004058","article-title":"Suppression of Human Natural Killer Cells by Different Classes of Opioids","volume":"128","author":"Maher","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2021.09.011_bib0070","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AIA.0000000000000112","article-title":"Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases?","volume":"54","author":"Aich","year":"2016","journal-title":"Int Anesthesiol Clin"},{"key":"10.1016\/j.bjane.2021.09.011_bib0075","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1038\/srep11389","article-title":"Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages","volume":"5","author":"Khabbazi","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bjane.2021.09.011_bib0080","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1213\/ANE.0000000000001652","article-title":"Perioperative Anesthesia Care and Tumor Progression","volume":"124","author":"Sekandarzad","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2021.09.011_bib0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000360300","article-title":"Impact of thoracic epidural analgesia on blood loss in radical retropubic prostatectomy","volume":"93","author":"Baumunk","year":"2014","journal-title":"Urol Int"},{"key":"10.1016\/j.bjane.2021.09.011_bib0090","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1213\/ANE.0000000000004058","article-title":"Suppression of Human Natural Killer Cells by Different Classes of Opioids","volume":"128","author":"Maher","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2021.09.011_bib0095","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4065\/83.10.1116","article-title":"Development of peripheral opioid antagonists... new insights into opioid effects","volume":"83","author":"Moss","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.bjane.2021.09.011_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mvr.2006.04.004","article-title":"Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation","volume":"72","author":"Singleton","year":"2006","journal-title":"Microvasc Res"},{"key":"10.1016\/j.bjane.2021.09.011_bib0105","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/ALN.0b013e31824babe2","article-title":"Overexpression of the ..-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis","volume":"116","author":"Lennon","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2021.09.011_bib0110","first-page":"4491","article-title":"Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth","volume":"62","author":"Gupta","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.bjane.2021.09.011_bib0115","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neo.2020.12.011","article-title":"Opioids drive breast cancer metastasis through the ..-opioid receptor and oncogenic STAT3","volume":"23","author":"Tripolt","year":"2021","journal-title":"Neoplasia"},{"key":"10.1016\/j.bjane.2021.09.011_bib0120","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bpa.2019.07.004","article-title":"The role of regional anesthesia in the propagation of cancer: A comprehensive review","volume":"33","author":"Sen","year":"2019","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1016\/j.bjane.2021.09.011_bib0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00210-011-0672-4","article-title":"The role of morphine in regulation of cancer cell growth","volume":"384","author":"Gach","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bjane.2021.09.011_bib0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SLE.0000000000000630","article-title":"Effects of a Preoperative Transdermal Fentanyl Patch on Proinflammatory Cytokine and Pain Levels During the Postoperative Period: A Randomized Controlled Trial","volume":"29","author":"Kwon","year":"2019","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"10.1016\/j.bjane.2021.09.011_bib0135","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/1547691X.2011.620036","article-title":"Intravenous anesthetic propofol suppresses prostaglandin E2 production in murine dendritic cells","volume":"8","author":"Inada","year":"2011","journal-title":"J Immunotoxicol"},{"key":"10.1016\/j.bjane.2021.09.011_bib0140","first-page":"1464","article-title":"Intravenous, Perioperatively Administered Lidocaine Regulates Serum Pain Modulators... Concentrations in Children Undergoing Spinal Surgery Pain","volume":"21","author":"Ko.\u00f3cielniak-Merak","year":"2020","journal-title":"Med"},{"key":"10.1016\/j.bjane.2021.09.011_bib0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5055\/jom.2017.0392","article-title":"Impact of opioids on oxidative status and related signaling pathways: An integrated view","volume":"13","author":"Zahmatkesh","year":"2017","journal-title":"J Opioid Manag"},{"key":"10.1016\/j.bjane.2021.09.011_bib0150","first-page":"5995","article-title":"How does the anesthetic agent propofol affect tumors?","volume":"10","author":"Wei","year":"2017","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"10.1016\/j.bjane.2021.09.011_bib0151","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.clbc.2014.05.002","article-title":"Impact of tumor removal on the systemic oxidative profile of patients with breast cancer discloses lipid peroxidation at diagnosis as a putative marker of disease recurrence","volume":"14","author":"Herrera","year":"2014","journal-title":"Clin Breast Cancer"}],"container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001421003626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001421003626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:01:46Z","timestamp":1758830506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0104001421003626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0104001421003626"],"URL":"https:\/\/doi.org\/10.1016\/j.bjane.2021.09.011","relation":{},"ISSN":["0104-0014"],"issn-type":[{"type":"print","value":"0104-0014"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of exogenous opioids on the acute inflammatory response in the perioperative period of oncological surgery: a clinical study","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2021.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}],"article-number":"744290"}}