{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:42Z","timestamp":1791229662670,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.bjane.2022.10.004","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:26:58Z","timestamp":1666931218000},"page":"186-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Importance of assessing biomarkers and physiological parameters of anemia-induced tissue hypoxia in the perioperative period"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-1686","authenticated-orcid":false,"given":"Kyle","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-0689","authenticated-orcid":false,"given":"Helen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-7902","authenticated-orcid":false,"given":"Chloe","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-3033","authenticated-orcid":false,"given":"Iryna","family":"Savinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Sklar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0348","authenticated-orcid":false,"given":"Fabio","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4482-547X","authenticated-orcid":false,"given":"Jeremy","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. David","family":"Mazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Darrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-4818","authenticated-orcid":false,"given":"Gregory M.T.","family":"Hare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjane.2022.10.004_bib0001","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1111\/trf.13732","article-title":"Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery","volume":"56","author":"Goobie","year":"2016","journal-title":"Transfusion"},{"key":"10.1016\/j.bjane.2022.10.004_bib0002","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/s-0035-1571202","article-title":"Short- and Long-Term Outcomes for Extremely Preterm Infants","volume":"33","author":"Patel","year":"2016","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0140-6736(08)61034-X","article-title":"Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial","volume":"372","author":"Clarke","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bjane.2022.10.004_bib0004","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jamapediatrics.2015.4276","article-title":"Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study","volume":"170","author":"Kyu","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.bjane.2022.10.004_bib0005","doi-asserted-by":"crossref","first-page":"e548","DOI":"10.1016\/S2214-109X(18)30078-0","article-title":"Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis","volume":"6","author":"Daru","year":"2018","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.bjane.2022.10.004_bib0006","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12884-015-0669-y","article-title":"Factors associated with postpartum hemorrhage maternal death in referral hospitals in Senegal and Mali: a cross-sectional epidemiological survey","volume":"15","author":"Tort","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0007","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1001\/archinte.165.19.2214","article-title":"A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study","volume":"165","author":"Zakai","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0008","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/gerona\/61.5.474","article-title":"Anemia in old age is associated with increased mortality and hospitalization","volume":"61","author":"Penninx","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.bjane.2022.10.004_bib0009","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bjane.2022.10.004_bib0010","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/ALN.0000000000003870","article-title":"Anemia: perioperative risk and treatment opportunity","volume":"135","author":"Hare","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0011","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1213\/ANE.0000000000004727","article-title":"Perioperative anemia: prevention, diagnosis, and management throughout the spectrum of perioperative care","volume":"130","author":"Warner","year":"2020","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.bjane.2022.10.004_bib0012","doi-asserted-by":"crossref","first-page":"i41","DOI":"10.1093\/bja\/aer350","article-title":"What is really dangerous: anaemia or transfusion?","volume":"107","author":"Shander","year":"2011","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0013","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0140-6736(96)04330-9","article-title":"Effect of anaemia and cardiovascular disease on surgical mortality and morbidity","volume":"348","author":"Carson","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.bjane.2022.10.004_bib0014","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(88)91536-X","article-title":"Severity of anaemia and operative mortality and morbidity","volume":"1","author":"Carson","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.bjane.2022.10.004_bib0015","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/trf.14768","article-title":"Severe anemia associated with increased risk of death and myocardial ischemia in patients declining blood transfusion","volume":"58","author":"Guinn","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.bjane.2022.10.004_bib0016","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/TA.0000000000002632","article-title":"Lower hemoglobin concentration decreases time to death in severely anemic patients for whom blood transfusion is not an option","volume":"88","author":"Guinn","year":"2020","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0017","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1111\/trf.12565","article-title":"An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME)","volume":"54","author":"Shander","year":"2014","journal-title":"Transfusion"},{"key":"10.1016\/j.bjane.2022.10.004_bib0018","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1111\/trf.16122","article-title":"The need for an artificial oxygen carrier for disasters and pandemics, including COVID-19","volume":"60","author":"Weiskopf","year":"2020","journal-title":"Transfusion"},{"key":"10.1016\/j.bjane.2022.10.004_bib0019","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/bjs.9861","article-title":"Meta-analysis of the association between preoperative anaemia and mortality after surgery","volume":"102","author":"Fowler","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0020","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0140-6736(11)61381-0","article-title":"Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study","volume":"378","author":"Musallam","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bjane.2022.10.004_bib0021","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.athoracsur.2019.04.108","article-title":"Preoperative anemia and outcomes in cardiovascular surgery: systematic review and meta-analysis","volume":"108","author":"Padmanabhan","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0022","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/CIRCULATIONAHA.107.718353","article-title":"Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study","volume":"117","author":"Karkouti","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bjane.2022.10.004_bib0023","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/CIRCULATIONAHA.106.653501","article-title":"Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery","volume":"116","author":"Kulier","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bjane.2022.10.004_bib0024","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.athoracsur.2005.03.137","article-title":"Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery","volume":"80","author":"Karkouti","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0025","doi-asserted-by":"crossref","first-page":"R799","DOI":"10.1152\/ajpregu.00323.2019","article-title":"Renal tissue PO2 sensing during acute hemodilution is dependent on the diluent","volume":"318","author":"Abrahamson","year":"2020","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0026","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12630-020-01848-5","article-title":"Renal microvascular oxygen tension during hyperoxia and acute hemodilution assessed by phosphorescence quenching and excitation with blue and red light","volume":"68","author":"Chin","year":"2021","journal-title":"Can J Anaesth"},{"issue":"12","key":"10.1016\/j.bjane.2022.10.004_bib0027","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/ndt\/gfy047","article-title":"Urinary hypoxia: an intraoperative marker of risk of cardiac surgery-associated acute kidney injury","volume":"33","author":"Zhu","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.bjane.2022.10.004_bib0028","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/ALN.0000000000003663","article-title":"Noninvasive Urine Oxygen Monitoring and the Risk of Acute Kidney Injury in Cardiac Surgery","volume":"135","author":"Silverton","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0029","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1177\/0267659113490219","article-title":"Anemia increases the risk of renal cortical and medullary hypoxia during cardiopulmonary bypass","volume":"28","author":"Darby","year":"2013","journal-title":"Perfusion"},{"key":"10.1016\/j.bjane.2022.10.004_bib0030","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s12630-018-1140-0","article-title":"Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury","volume":"65","author":"Hare","year":"2018","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0031","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1007\/s00415-010-5657-6","article-title":"Cerebral infarction in acute anemia","volume":"257","author":"Tsai","year":"2010","journal-title":"J Neurol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0032","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1182\/blood-2014-09-599852","article-title":"Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia","volume":"125","author":"Bernaudin","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bjane.2022.10.004_bib0033","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/japplphysiol.01340.2010","article-title":"Metoprolol impairs resistance artery function in mice","volume":"111","author":"El Beheiry","year":"2011","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0034","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/bja\/ael238","article-title":"Beta2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe haemodilution in rats","volume":"97","author":"Hare","year":"2006","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1213\/ANE.0b013e318280e26d","article-title":"Treatment with a highly selective \u03b21 antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats","volume":"116","author":"Hu","year":"2013","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0036","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/ALN.0b013e3181b87f0e","article-title":"Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats","volume":"111","author":"Ragoonanan","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0037","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/ALN.0b013e3182a17f12","article-title":"Selective \u03b21-antagonism with bisoprolol is associated with fewer postoperative strokes than atenolol or metoprolol: a single-center cohort study of 44,092 consecutive patients","volume":"119","author":"Ashes","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0038","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12630-015-0494-9","article-title":"Perioperative stroke","volume":"63","author":"Vlisides","year":"2016","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0039","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1213\/01.ANE.0000131504.90754.D0","article-title":"Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats","volume":"99","author":"Homi","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bpa.2012.12.002","article-title":"Anaemia: can we define haemoglobin thresholds for impaired oxygen homeostasis and suggest new strategies for treatment?","volume":"27","author":"Hare","year":"2013","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0041","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1152\/ajpregu.00411.2013","article-title":"Differential HIF and NOS responses to acute anemia: defining organ-specific hemoglobin thresholds for tissue hypoxia","volume":"307","author":"Tsui","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0042","first-page":"170","article-title":"Concise Observations on An\u00e6mia","volume":"3","author":"Halle","year":"1807","journal-title":"Edinb Med Surg J"},{"key":"10.1016\/j.bjane.2022.10.004_bib0043","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/cvr\/6.4.360","article-title":"Coronary blood flow and myocardial metabolism in acute experimental anaemia","volume":"6","author":"Murray","year":"1972","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bjane.2022.10.004_bib0044","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/00000542-200209000-00021","article-title":"Henny Ch P. Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model","volume":"97","author":"van Bommel","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-4684-5481-9_9","article-title":"Circulatory adjustments to anemic hypoxia","volume":"227","author":"Cain","year":"1988","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0046","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1139\/y86-002","article-title":"The physiologic reserve in oxygen carrying capacity: studies in experimental hemodilution","volume":"64","author":"Chapler","year":"1986","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0047","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1172\/JCI101610","article-title":"Stead EA. The Cardiac Output in Patients with Chronic Anemia as Measured by the Technique of Right Atrial Catheterization","volume":"24","author":"Brannon","year":"1945","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bjane.2022.10.004_bib0048","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jama.279.3.217","article-title":"Human cardiovascular and metabolic response to acute, severe isovolemic anemia","volume":"279","author":"Weiskopf","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.bjane.2022.10.004_bib0049","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/00000542-200006000-00023","article-title":"Acute severe isovolemic anemia impairs cognitive function and memory in humans","volume":"92","author":"Weiskopf","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0050","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.clinph.2004.12.009","article-title":"Acute isovolemic anemia impairs central processing as determined by P300 latency","volume":"116","author":"Weiskopf","year":"2005","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0051","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1152\/japplphysiol.00931.2002","article-title":"Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression","volume":"94","author":"Hare","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0052","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1152\/ajpregu.00403.2006","article-title":"Increased expression of HIF-1\u03b1, nNOS, and VEGF in the cerebral cortex of anemic rats","volume":"292","author":"McLaren","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0053","doi-asserted-by":"crossref","first-page":"R611","DOI":"10.1152\/ajpregu.00182.2017","article-title":"Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain","volume":"314","author":"Mistry","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0054","doi-asserted-by":"crossref","first-page":"17544","DOI":"10.1073\/pnas.1114026108","article-title":"Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia","volume":"108","author":"Tsui","year":"2011","journal-title":"Pro Natl Acad Sci USA."},{"key":"10.1016\/j.bjane.2022.10.004_bib0055","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1152\/japplphysiol.01315.2005","article-title":"Dual-wavelength phosphorimetry for determination of cortical and subcortical microvascular oxygenation in rat kidney","volume":"100","author":"Johannes","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0056","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.trsl.2007.11.001","article-title":"Heart, kidney, and intestine have different tolerances for anemia","volume":"151","author":"van Bommel","year":"2008","journal-title":"Transl Res"},{"key":"10.1016\/j.bjane.2022.10.004_bib0057","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/embor.2010.170","article-title":"The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens","volume":"12","author":"Loenarz","year":"2011","journal-title":"EMBO Rep"},{"key":"10.1016\/j.bjane.2022.10.004_bib0058","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/molbev\/msr012","article-title":"Molecular evolution of the metazoan PHD-HIF oxygen-sensing system","volume":"28","author":"Rytk\u00f6nen","year":"2011","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0059","first-page":"696","article-title":"Anemia as a stimulus to aortic and carotid chemoreceptors in the cat","volume":"44","author":"Hatcher","year":"1978","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"S1","key":"10.1016\/j.bjane.2022.10.004_bib0060","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2022.36.S1.R3460","article-title":"Bilateral Nephrectomy Impairs Cerebral Oxygen Delivery After Acute Hemodilution Anemia in Rats","volume":"36","author":"Chin","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.bjane.2022.10.004_bib0061","first-page":"F474","article-title":"Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia","volume":"263","author":"Tan","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0062","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/japplphysiol.01315.2006","article-title":"Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma","volume":"103","author":"Hare","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0063","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/ALN.0b013e31822a22be","article-title":"High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion","volume":"115","author":"Feiner","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0064","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/CCM.0000000000002283","article-title":"Liberal versus restrictive transfusion strategy in critically Ill oncologic patients: the transfusion requirements in critically Ill oncologic patients randomized controlled trial","volume":"45","author":"Bergamin","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0065","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJMoa071533","article-title":"Efficacy and safety of epoetin alfa in critically ill patients","volume":"357","author":"Corwin","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0066","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1001\/jama.288.22.2827","article-title":"Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial","volume":"288","author":"Corwin","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.bjane.2022.10.004_bib0067","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13054-020-03430-3","article-title":"Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial","volume":"25","author":"Lasocki","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.bjane.2022.10.004_bib0068","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(20)31539-7","article-title":"Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial","volume":"396","author":"Richards","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bjane.2022.10.004_bib0069","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/1440-1681.13603","article-title":"Intra-operative and early post-operative prediction of cardiac surgery-associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers","volume":"49","author":"Noe","year":"2022","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.bjane.2022.10.004_bib0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1001\/jama.2019.20833","article-title":"Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial","volume":"323","author":"Futier","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.bjane.2022.10.004_bib0071","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jama.2013.430","article-title":"Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta-analysis","volume":"309","author":"Zarychanski","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.bjane.2022.10.004_bib0072","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/ALN.0000000000001029","article-title":"Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial","volume":"124","author":"Deschamps","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjane.2022.10.004_bib0073","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1213\/01.ane.0000246814.29362.f4","article-title":"Monitoring brain oxygen saturation during coronary bypass surgery: a randomized, prospective study","volume":"104","author":"Murkin","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0074","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/CCM.0000000000002619","article-title":"Brain oxygen optimization in severe traumatic brain injury phase-II: A Phase II Randomized Trial","volume":"45","author":"Okonkwo","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0076","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/uog.18807","article-title":"Fetal middle cerebral artery Doppler to time intrauterine transfusion in red-cell alloimmunization: a randomized trial","volume":"51","author":"Dodd","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.bjane.2022.10.004_bib0077","article-title":"The effects of anesthetics on the cortex-lessons from event-related potentials","volume":"14","author":"Baron Shahaf","year":"2020","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.bjane.2022.10.004_bib0078","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.xjtc.2021.01.023","article-title":"The role of diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy in monitoring cerebral hemodynamics during hypothermic circulatory arrests","volume":"7","author":"Zavriyev","year":"2021","journal-title":"JTCVS Tech"},{"key":"10.1016\/j.bjane.2022.10.004_bib0079","first-page":"E146","article-title":"Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation","volume":"97","author":"Seppelt","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.bjane.2022.10.004_bib0080","article-title":"Cerebral blood flow monitoring in high-risk fetal and neonatal populations","volume":"9","author":"Leon","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.bjane.2022.10.004_bib0081","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V74.2.645.645","article-title":"Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration","volume":"74","author":"Koury","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.bjane.2022.10.004_bib0082","first-page":"3373","article-title":"The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice","volume":"119","author":"Weidemann","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bjane.2022.10.004_bib0083","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.4103\/1673-5374.215240","article-title":"Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor","volume":"12","author":"Hern\u00e1ndez","year":"2017","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bjane.2022.10.004_bib0084","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s001340050310","article-title":"Erythropoietin response is blunted in critically ill patients","volume":"23","author":"Rogiers","year":"1997","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0085","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1007\/s00134-013-3030-9","article-title":"Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis","volume":"39","author":"Mesgarpour","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0086","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s12630-019-01351-6","article-title":"Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis","volume":"66","author":"Kei","year":"2019","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0087","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1213\/ANE.0000000000004005","article-title":"Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis","volume":"128","author":"Cho","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2022.10.004_bib0088","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s10020-020-00186-y","article-title":"Erythropoietin as candidate for supportive treatment of severe COVID-19","volume":"26","author":"Ehrenreich","year":"2020","journal-title":"Mol Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0089","article-title":"Transfusion thresholds for guiding red blood cell transfusion","volume":"12","author":"Carson","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjane.2022.10.004_bib0090","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/eurheartj\/ehy435","article-title":"Restrictive compared with liberal red cell transfusion strategies in cardiac surgery: a meta-analysis","volume":"40","author":"Shehata","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bjane.2022.10.004_bib0091","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMoa1012452","article-title":"Liberal or restrictive transfusion in high-risk patients after hip surgery","volume":"365","author":"Carson","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjane.2022.10.004_bib0092","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.ahj.2013.03.001","article-title":"Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease","volume":"165","author":"Carson","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.bjane.2022.10.004_bib0093","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/CIRCULATIONAHA.121.057909","article-title":"One-year major cardiovascular events after restrictive versus liberal blood transfusion strategy in patients with acute myocardial infarction and anemia: The REALITY randomized trial","volume":"145","author":"Gonzalez-Juanatey","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.bjane.2022.10.004_bib0094","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1007\/s12630-020-01763-9","article-title":"When to transfuse your acute care patient? A narrative review of the risk of anemia and red blood cell transfusion based on clinical trial outcomes","volume":"67","author":"Hare","year":"2020","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.bjane.2022.10.004_bib0095","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJMoa1808561","article-title":"Six-month outcomes after restrictive or liberal transfusion for cardiac surgery","volume":"379","author":"Mazer","year":"2018","journal-title":"N Engl J Med"}],"container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001422001373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0104001422001373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:01:02Z","timestamp":1758830462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0104001422001373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0104001422001373"],"URL":"https:\/\/doi.org\/10.1016\/j.bjane.2022.10.004","relation":{},"ISSN":["0104-0014"],"issn-type":[{"value":"0104-0014","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importance of assessing biomarkers and physiological parameters of anemia-induced tissue hypoxia in the perioperative period","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2022.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia.","name":"copyright","label":"Copyright"}]}}