{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:12:30Z","timestamp":1771661550766,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bjane.2024.844518","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T02:40:24Z","timestamp":1716432024000},"page":"844518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Determination of ED50 and ED95 of remimazolam besylate combined with alfentanil for adult gastroscopy: a prospective dose-finding study"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-0150","authenticated-orcid":false,"given":"Pingjuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8915-1241","authenticated-orcid":false,"given":"Song","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liufei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9554-3749","authenticated-orcid":false,"given":"Kunkun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-5706","authenticated-orcid":false,"given":"Yiqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjane.2024.844518_bib0001","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8845129","article-title":"Effects of Remimazolam and Propofol on Ca (2+) Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation","volume":"2021","author":"Watanabe","year":"2021","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bjane.2024.844518_bib0002","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12871-021-01373-y","article-title":"Efficacy and safety of remimazolam besylate versus propofol during hysteroscopy: single-centre randomized controlled trial","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.bjane.2024.844518_bib0003","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1213\/ANE.0000000000000548","article-title":"A Phase IIa, randomized, double-blind study of remimazolam (CNS 7056) versus midazolam for sedation in upper gastrointestinal endoscopy","volume":"120","author":"Borkett","year":"2015","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2024.844518_bib0004","doi-asserted-by":"crossref","first-page":"223","DOI":"10.23736\/S0375-9393.21.15917-6","article-title":"Gastroscopy sedation: clinical trial comparing propofol and sufentanil with or without remimazolam","volume":"88","author":"Xiao","year":"2022","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.bjane.2024.844518_bib0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1213\/ANE.0000000000003681","article-title":"Pupillary Pain Index Changes After a Standardized Bolus of Alfentanil Under Sevoflurane Anesthesia: First Evaluation of a New Pupillometric Index to Assess the Level of Analgesia During General Anesthesia","volume":"128","author":"Sabourdin","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.bjane.2024.844518_bib0006","article-title":"The Efficacy and Safety of Remimazolam Tosilate Versus Dexmedetomidine in Outpatients Undergoing Flexible Bronchoscopy: A Prospective, Randomized, Blind, Non-Inferiority Trial","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bjane.2024.844518_bib0007","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.gie.2008.09.029","article-title":"Sedation and anesthesia in GI endoscopy","volume":"68","author":"Lichtenstein","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.bjane.2024.844518_bib0008","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1067\/mge.2001.111773","article-title":"Evaluation of topical pharyngeal anesthesia for upper endoscopy including factors associated with patient tolerance","volume":"53","author":"Soma","year":"2001","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.bjane.2024.844518_bib0009","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajhp\/zxab091","volume":"78","author":"Besylate","year":"2021","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.bjane.2024.844518_bib0010","article-title":"Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study","volume":"28","author":"Cao","year":"2022","journal-title":"Med Sci Monit"}],"container-title":["Brazilian Journal of Anesthesiology (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010400142400040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S010400142400040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T01:15:44Z","timestamp":1719623744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S010400142400040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S010400142400040X"],"URL":"https:\/\/doi.org\/10.1016\/j.bjane.2024.844518","relation":{},"ISSN":["0104-0014"],"issn-type":[{"value":"0104-0014","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of ED50 and ED95 of remimazolam besylate combined with alfentanil for adult gastroscopy: a prospective dose-finding study","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Anesthesiology (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjane.2024.844518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Anestesiologia.","name":"copyright","label":"Copyright"}],"article-number":"844518"}}