{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:28:37Z","timestamp":1768872517133,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5K08GM115861-04"],"award-info":[{"award-number":["5K08GM115861-04"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjaopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BJA Open"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bjao.2022.100014","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T04:58:42Z","timestamp":1653109122000},"page":"100014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Intraoperative administration of isoflurane improves survival in rats exposed to caecal ligation and puncture"],"prefix":"10.1016","volume":"2","author":[{"given":"Keita","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari P.","family":"Osuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjao.2022.100014_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bjao.2022.100014_bib2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/ALN.0b013e3182a2a38c","article-title":"Volatile anesthetics improve survival after cecal ligation and puncture","volume":"119","author":"Herrmann","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjao.2022.100014_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/SHK.0b013e3181cffc3f","article-title":"Subanesthetic dose of isoflurane protects against zymosan-induced generalized inflammation and its associated acute lung injury in mice","volume":"34","author":"Mu","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.bjao.2022.100014_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.shk.0000248595.17130.24","article-title":"Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis","volume":"27","author":"Lee","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.bjao.2022.100014_bib5","first-page":"63","article-title":"Volatile anesthetic isoflurane attenuates liver injury in experimental polymicrobial sepsis model","volume":"5","author":"Koutsogiannaki","year":"2018","journal-title":"Transl Perioper Pain Med"},{"key":"10.1016\/j.bjao.2022.100014_bib6","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.jss.2011.12.037","article-title":"Volatile anesthetic pre-conditioning attenuated sepsis induced lung inflammation","volume":"178","author":"Bedirli","year":"2012","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.bjao.2022.100014_bib7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/ALN.0b013e3182a2a3a4","article-title":"Sleeping to survive? The impact of volatile anesthetics on mortality in sepsis","volume":"119","author":"Kharasch","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bjao.2022.100014_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000107614","article-title":"Isoflurane inhalation after induction of endotoxemia in rats attenuates the systemic cytokine response","volume":"40","author":"Flondor","year":"2008","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.bjao.2022.100014_bib9","first-page":"1139","article-title":"Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats","volume":"17","author":"Boost","year":"2006","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.bjao.2022.100014_bib10","doi-asserted-by":"crossref","first-page":"11016","DOI":"10.1016\/j.biopha.2020.110169","article-title":"A\u00a0subanesthetic dose of sevoflurane combined with oxygen exerts bactericidal effects and prevents lung injury through the nitric oxide pathway during sepsis","volume":"127","author":"Zhang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bjao.2022.100014_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12868-019-0514-8","article-title":"Impact of inflammation on brain subcellular energetics in anesthetized rats","volume":"20","author":"Thiele","year":"2019","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.bjao.2022.100014_bib12","doi-asserted-by":"crossref","first-page":"581082","DOI":"10.3389\/fmed.2020.581082","article-title":"Anesthesia-sepsis-associated alterations in liver gene expression profiles and mitochondrial oxidative phosphorylation complexes","volume":"7","author":"Osuru","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.bjao.2022.100014_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13054-015-0751-x","article-title":"Propofol increases morbidity and mortality in a rat model of sepsis","volume":"19","author":"Schl\u00e4pfer","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.bjao.2022.100014_bib14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/EJA.0000000000000668","article-title":"Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: a laboratory rat study","volume":"34","author":"Beck-Schimmer","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.bjao.2022.100014_bib15","first-page":"55","article-title":"The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions","volume":"7","author":"Sotocinal","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.bjao.2022.100014_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pneurobio.2019.02.002","article-title":"Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back","volume":"177","author":"Demartini","year":"2019","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bjao.2022.100014_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pu.09.050188.001011","article-title":"A\u00a0general overview of Mantel-Haenszel methods: applications and recent developments","volume":"9","author":"Kuritz","year":"1988","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.bjao.2022.100014_bib18","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/AAC.48.8.2787-2792.2004","article-title":"Hazard ratio in clinical trials","volume":"48","author":"Spruance","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bjao.2022.100014_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.bjao.2022.100014_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/sur.2008.046","article-title":"Trends in postoperative sepsis: are we improving outcomes?","volume":"10","author":"Vogel","year":"2009","journal-title":"Surg Infect"},{"key":"10.1016\/j.bjao.2022.100014_bib21","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1001\/archsurg.134.12.1342","article-title":"Gender-based differences in outcome in patients with sepsis","volume":"134","author":"Eachempati","year":"1999","journal-title":"Arch Surg"},{"key":"10.1016\/j.bjao.2022.100014_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4161\/viru.26982","article-title":"Gender differences in sepsis: cardiovascular and immunological aspects","volume":"5","author":"Angele","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.bjao.2022.100014_bib23","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1038\/s41598-020-72537-y","article-title":"Sex differences of inflammatory and immune response in pups of Wistar rats with SIRS","volume":"10","author":"Kosyreva","year":"2020","journal-title":"Sci Rep"}],"container-title":["BJA Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772609622000132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772609622000132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:51:19Z","timestamp":1757418679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772609622000132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":23,"alternative-id":["S2772609622000132"],"URL":"https:\/\/doi.org\/10.1016\/j.bjao.2022.100014","relation":{},"ISSN":["2772-6096"],"issn-type":[{"value":"2772-6096","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraoperative administration of isoflurane improves survival in rats exposed to caecal ligation and puncture","name":"articletitle","label":"Article Title"},{"value":"BJA Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjao.2022.100014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of British Journal of Anaesthesia.","name":"copyright","label":"Copyright"}],"article-number":"100014"}}