{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:58:48Z","timestamp":1754398728049},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Brasileira de Hematologia e Hemoterapia"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bjhh.2014.05.005","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T12:45:54Z","timestamp":1401281154000},"page":"345-350","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment"],"prefix":"10.1016","volume":"36","author":[{"given":"Ana Maria Almeida","family":"Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Pimentel","family":"Muniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Maciel","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bjhh.2014.05.005_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S1516-84842008000100005","article-title":"Estudo da Doen\u00e7a de Gaucher em Santa Catarina","volume":"30","author":"Ferreira","year":"2008","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"2","key":"10.1016\/j.bjhh.2014.05.005_bib0010","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2141.2004.05351.x","article-title":"Gaucher Disease: pathological mechanisms and modern management","volume":"129","author":"Jmoudiak","year":"2005","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.bjhh.2014.05.005_bib0015","first-page":"193","article-title":"Avalia\u00e7\u00e3o de dois anos de tratamento da doen\u00e7a de Gaucher tipo 1 com terapia de reposi\u00e7\u00e3o enzim\u00e1tica em pacientes do estado de S\u00e3o Paulo","volume":"30","author":"Sobreira","year":"2008","journal-title":"Brasil Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0020","series-title":"Avalia\u00e7\u00e3o da Qualidade de Vida de Pacientes com Doen\u00e7a de Gaucher. Doen\u00e7a de Fabry e Mucopolissacaridoses","author":"Oliveira","year":"2010"},{"issue":"6","key":"10.1016\/j.bjhh.2014.05.005_bib0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/archpedi.160.6.603","article-title":"The clinical and demographic characteristics of nonneuronopathic Gaucher Disease in 887 children at diagnosis","volume":"160","author":"Kaplan","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0030","article-title":"Gaucher Disease","author":"Pastores","year":"2011","journal-title":"Gene Rev"},{"issue":"2","key":"10.1016\/j.bjhh.2014.05.005_bib0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S1516-84842003000200004","article-title":"Tratamento da doen\u00e7a de Gaucher: um consenso brasileiro","volume":"25","author":"Martins","year":"2003","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"21","key":"10.1016\/j.bjhh.2014.05.005_bib0040","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency \u2013 macrophage targeted glucorebrosidase for Gaucher's Disease","volume":"324","author":"Barton","year":"1991","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.bjhh.2014.05.005_bib0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7326\/0003-4819-122-1-199501010-00005","article-title":"Enzyme therapy in Type 1 Gaucher Disease: comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinat sources","volume":"122","author":"Grabowski","year":"1995","journal-title":"Ann Intern Med"},{"issue":"Suppl 3","key":"10.1016\/j.bjhh.2014.05.005_bib0050","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1590\/S1413-81232010000900019","article-title":"Medicamentos de alto custo para doen\u00e7as raras no Brasil: o exemplo das doen\u00e7as lisoss\u00f4micas","volume":"15","author":"Souza","year":"2010","journal-title":"Cien Saude Colet"},{"issue":"18","key":"10.1016\/j.bjhh.2014.05.005_bib0055","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1001\/archinte.160.18.2835","article-title":"The Gaucher registry \u2013 demographics and disease characteristics of 1698 patients with Gaucher disease","volume":"160","author":"Charrow","year":"2000","journal-title":"Arch Intern Med"},{"issue":"12","key":"10.1016\/j.bjhh.2014.05.005_bib0060","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3324\/haematol.2009.008078","article-title":"Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project","volume":"94","author":"Giraldo","year":"2009","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.bjhh.2014.05.005_bib0065","first-page":"273","article-title":"Enfermedad de Gaucher En Latinoam\u00e9rica\u2013Un Informe Del Registro Internacional Y Del Grupo Latinoamericano Para La Enfermedad de Gaucher","volume":"72","author":"Drelichman","year":"2012","journal-title":"Medicina (B Aires)"},{"issue":"6","key":"10.1016\/j.bjhh.2014.05.005_bib0070","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1542\/peds.2007-2144","article-title":"Eight-year clinical outcomes of long-term enzyme replacement therapy for 884 children with Gaucher Disease Type 1","volume":"122","author":"Andersson","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/8904_2012_174","article-title":"Novel mutations in the glucocerebrosidase gene of Brazilian patients with Gaucher disease","volume":"9","author":"Siebert","year":"2012","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0080","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2147\/TCRM.S6955","article-title":"Optimal therapy in Gaucher disease","volume":"6","author":"Goker-Alpan","year":"2010","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0085","first-page":"299","article-title":"Gaucher Disease: clinical profile and therapeutic developments","volume":"4","author":"Cox","year":"2010","journal-title":"Biologics"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0090","series-title":"Clinical Protocol and Therapeutic Guidelines","author":"Brazil. Gaucher Disease. Ministry of Health. Secretary of Attention to Health","year":"2011"},{"issue":"12","key":"10.1016\/j.bjhh.2014.05.005_bib0095","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ajh.21280","article-title":"A benchmark analysis of the achievement of therapeutic goals for type 1 Gaucher disease patients treated with imiglucerase","volume":"83","author":"Weinreb","year":"2008","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bjhh.2014.05.005_bib0100","first-page":"151506","article-title":"Achievement of therapeutic goals with low-dose imiglucerase in Gaucher Disease: a single center experience","author":"Tukan","year":"2013","journal-title":"Adv Hematol"},{"issue":"20","key":"10.1016\/j.bjhh.2014.05.005_bib0105","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1182\/blood-2010-06-293902","article-title":"Improvement in hematological, visceral, and skeletal manifestations of Gaucher Disease type 1 with oral eliglustat tartrate (GENZ-112638) treatment: 2-year results of a phase 2 study","volume":"116","author":"Lukina","year":"2010","journal-title":"Blood"}],"container-title":["Revista Brasileira de Hematologia e Hemoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1516848414000425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1516848414000425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T20:51:36Z","timestamp":1538599896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1516848414000425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1516848414000425"],"URL":"https:\/\/doi.org\/10.1016\/j.bjhh.2014.05.005","relation":{},"ISSN":["1516-8484"],"issn-type":[{"value":"1516-8484","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment","name":"articletitle","label":"Article Title"},{"value":"Revista Brasileira de Hematologia e Hemoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjhh.2014.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}