{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:02:57Z","timestamp":1791849777753,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Brasileira de Hematologia e Hemoterapia"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.bjhh.2015.03.009","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T17:27:54Z","timestamp":1429118874000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Acute lymphoblastic leukemia in children and adolescents: prognostic factors and analysis of survival"],"prefix":"10.1016","volume":"37","author":[{"given":"Daniel Willian","family":"Lustosa de Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Valdeci","family":"de Almeida Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Helder","family":"Cavalcante F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicios","family":"de Oliveira Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjhh.2015.03.009_bib0155","series-title":"Nathan and Oski's Hematology of Infancy and childhood","first-page":"1081","article-title":"Epidemiology of leukemia in childhood","author":"Bathia","year":"2003"},{"issue":"9617","key":"10.1016\/j.bjhh.2015.03.009_bib0160","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","article-title":"Acute lymphoblastic leukemia","volume":"371","author":"Pui","year":"2008","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bjhh.2015.03.009_bib0165","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1182\/blood-2007-09-112920","article-title":"Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the Trial ALL-BFM 95","volume":"111","author":"M\u00f6ricke","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bjhh.2015.03.009_bib0170","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1200\/JCO.1996.14.1.18","article-title":"Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia","volume":"14","author":"Smith","year":"1996","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.bjhh.2015.03.009_bib0175","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1634\/theoncologist.5-4-321","article-title":"The role of prognostic features in the treatment of childhood acute lymphoblastic leukemia","volume":"5","author":"Friedmann","year":"2000","journal-title":"Oncologist"},{"issue":"6","key":"10.1016\/j.bjhh.2015.03.009_bib0180","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-2005-872515","article-title":"Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL-BFM 86, 90, and 95","volume":"217","author":"Moricke","year":"2005","journal-title":"Klin Padiatr"},{"issue":"12","key":"10.1016\/j.bjhh.2015.03.009_bib0185","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1182\/blood-2008-01-132837","article-title":"Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group Study","volume":"111","author":"Borowitz","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0190","series-title":"Sociedade Brasileira de Hematologia e Hemoterapia","author":"Sociedade Brasileira de Oncologia Pedi\u00e1trica","year":"1993"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0195","series-title":"Protocolo de Tratamento da Leucemia Linfobl\u00e1stica Aguda na Inf\u00e2ncia-GBTLI-LLA-1999, Campinas","author":"Sociedade Brasileira de Oncologia Pedi\u00e1trica","year":"2000"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0200","series-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2012"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0205","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc Ser B Methodol"},{"issue":"5","key":"10.1016\/j.bjhh.2015.03.009_bib0210","first-page":"762","article-title":"Biology and treatment of infant leukemia","volume":"9","author":"Pui","year":"1995","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.bjhh.2015.03.009_bib0215","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrclinonc.2011.77","article-title":"Optimal therapy for acute lymphoblastic leukemia in adolescents and young adults","volume":"8","author":"Schafer","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"10.1016\/j.bjhh.2015.03.009_bib0220","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1182\/blood-2008-01-130237","article-title":"What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies","volume":"112","author":"Stock","year":"2008","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bjhh.2015.03.009_bib0225","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1200\/JCO.2010.32.0325","article-title":"Improved prognosis for older adolescents with acute lymphoblastic leukemia","volume":"29","author":"Pui","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0230","series-title":"Estudo de sobrevida em crian\u00e7as portadoras de leucemia linfobl\u00e1stica aguda","author":"Barreto","year":"2001"},{"issue":"4","key":"10.1016\/j.bjhh.2015.03.009_bib0235","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1590\/S1519-38292007000400009","article-title":"Fatores progn\u00f3sticos em crian\u00e7as e adolescentes com Leucemia Linfoide Aguda","volume":"7","author":"Leite","year":"2007","journal-title":"Rev Bras Sa\u00fade Matern Infant"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0240","series-title":"Aspectos epidemiol\u00f3gicos, biotipologia e evolu\u00e7\u00e3o do tratamento da leucemia linfoc\u00edtica aguda na inf\u00e2ncia e adolesc\u00eancia no Rio Grande do Sul","author":"Pereira","year":"2010"},{"issue":"8","key":"10.1016\/j.bjhh.2015.03.009_bib0245","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1200\/JCO.1998.16.8.2854","article-title":"Prognostic significance of sex in childhood B precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study","volume":"16","author":"Shuster","year":"1998","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.bjhh.2015.03.009_bib0250","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/sj.leu.2401977","article-title":"Long-term results of large prospective trials in childhood acute lymphoblastic leukemia","volume":"14","author":"Schrappe","year":"2000","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.bjhh.2015.03.009_bib0255","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.V97.5.1211","article-title":"Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01","volume":"97","author":"Silverman","year":"2001","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bjhh.2015.03.009_bib0260","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3324\/haematol.13156","article-title":"Anemia and survival in childhood acute lymphoblastic leukemia","volume":"93","author":"Teuffel","year":"2008","journal-title":"Haematologica"},{"issue":"19","key":"10.1016\/j.bjhh.2015.03.009_bib0265","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1200\/JCO.2003.10.116","article-title":"Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience","volume":"21","author":"Goldberg","year":"2003","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.bjhh.2015.03.009_bib0270","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1200\/JCO.2007.12.3927","article-title":"Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Munster based chemotherapy","volume":"26","author":"Aric\u00f3","year":"2008","journal-title":"J Clin Oncol"},{"issue":"13","key":"10.1016\/j.bjhh.2015.03.009_bib0275","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1182\/blood-2012-06-437681","article-title":"Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results","volume":"121","author":"Dastugue","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bjhh.2015.03.009_bib0280","series-title":"Gene technology: stem cell and leukemia research","first-page":"421","article-title":"Prognostic value of day 8 peripheral blood response for children with acute lymphocytic leukemia","author":"Brandalise","year":"1996"},{"issue":"1","key":"10.1016\/j.bjhh.2015.03.009_bib0285","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood-2002-01-0006","article-title":"Prognostic significance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia","volume":"100","author":"Coustan-Smith","year":"2002","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bjhh.2015.03.009_bib0290","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3324\/haematol.12365","article-title":"Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: The Tokyo Children's Cancer Study Group (TCCSG) Study L99-15","volume":"93","author":"Manabe","year":"2008","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.bjhh.2015.03.009_bib0295","first-page":"1839","article-title":"Prognostic value of peripheral blood blast percentage on day 8 in long term cure in patients with ALL","volume":"3","author":"Vaghela","year":"2014","journal-title":"World J Pharmacy Pharm Sci"}],"container-title":["Revista Brasileira de Hematologia e Hemoterapia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1516848415000547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1516848415000547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T08:11:20Z","timestamp":1717834280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1516848415000547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1516848415000547"],"URL":"https:\/\/doi.org\/10.1016\/j.bjhh.2015.03.009","relation":{},"ISSN":["1516-8484"],"issn-type":[{"value":"1516-8484","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute lymphoblastic leukemia in children and adolescents: prognostic factors and analysis of survival","name":"articletitle","label":"Article Title"},{"value":"Revista Brasileira de Hematologia e Hemoterapia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjhh.2015.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}