{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:58:29Z","timestamp":1775069909040,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Brazilian Journal of Infectious Diseases"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.bjid.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T18:00:13Z","timestamp":1477332013000},"page":"599-604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals"],"prefix":"10.1016","volume":"20","author":[{"given":"Cezar Arthur Tavares","family":"Pinheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Dias de","family":"Mattos Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana\u00edna Vieira dos Santos","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin Franco","family":"Kelbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa de Souza Ribeiro","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Silva de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Amaral Tavares","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Monteiro da Cunha","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Tavares","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjid.2016.09.006_bib0255","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection","volume":"338","author":"Palella","year":"1998","journal-title":"New Engl J Med"},{"key":"10.1016\/j.bjid.2016.09.006_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.d6016","article-title":"Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study","volume":"343","author":"May","year":"2011","journal-title":"Brit Med J"},{"key":"10.1016\/j.bjid.2016.09.006_bib0265","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/QAD.0b013e32835a1156","article-title":"Risk, predictors, and mortality associated with non-AIDS events in newly diagnosed HIV-infected patients: role of antiretroviral therapy","volume":"27","author":"Masi\u00e1","year":"2013","journal-title":"AIDS"},{"key":"10.1016\/j.bjid.2016.09.006_bib0270","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-med-042909-093756","article-title":"HIV infection, inflammation, immunosenescence, and aging","volume":"62","author":"Deeks","year":"2011","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.bjid.2016.09.006_bib0275","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/cid\/cir627","article-title":"Premature age related comorbidities among HIV-infected persons compared with the general population","volume":"53","author":"Guaraldi","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bjid.2016.09.006_bib0280","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s13365-011-0073-y","article-title":"Accelerated aging and human immunodeficiency virus infection: emerging challenges of growing older in the era of successful antiretroviral therapy","volume":"18","author":"Bhatia","year":"2012","journal-title":"J Neurovirol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0285","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13195-015-0123-4","article-title":"HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?","volume":"7","author":"Cohen","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.bjid.2016.09.006_bib0290","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-0034-1372340","article-title":"HIV and aging: effects on the central nervous system","volume":"34","author":"Ca\u00f1izares","year":"2014","journal-title":"Semin Neurol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0295","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1001\/jama.2013.2963","article-title":"Management of human immunodeficiency virus infection in advanced age","volume":"309","author":"Greene","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.bjid.2016.09.006_bib0300","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.imlet.2004.10.003","article-title":"Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system","volume":"97","author":"Van Baarle","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.bjid.2016.09.006_bib0305","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/13550280290049615","article-title":"HIV-associated cognitive impairment before and after the advent of combination therapy","volume":"8","author":"Sacktor","year":"2002","journal-title":"J Neurovirol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0310","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/QAD.0b013e32828e4e27","article-title":"The prevalence and incidence of neurocognitive impairment in the HAART era","volume":"21","author":"Robertson","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.bjid.2016.09.006_bib0315","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00002030-200401001-00011","article-title":"Evidence for a change in aids dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of aids dementia complex","volume":"18","author":"Brew","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.bjid.2016.09.006_bib0320","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1086\/503565","article-title":"HIV infection and dementia in older adults","volume":"42","author":"Valcour","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bjid.2016.09.006_bib0325","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00002030-200401001-00003","article-title":"Prevalence of cognitive disorders differs as a function of age in HIV virus infection","volume":"18","author":"Becker","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.bjid.2016.09.006_bib0330","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s13365-012-0094-1","article-title":"Impact of HIV and aging on neuropsychological function","volume":"18","author":"Wendelken","year":"2012","journal-title":"J Neurovirol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002030-200401001-00001","article-title":"Introduction: HIV\/AIDS and aging","volume":"18","author":"Stoff","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.bjid.2016.09.006_bib0340","series-title":"The Gap Report","author":"Joint United Nations Programme on HIV\/AIDS","year":"2016"},{"key":"10.1016\/j.bjid.2016.09.006_bib0345","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1590\/0037-8682-0034-2015","article-title":"Prevalence of neurocognitive disorders and depression in a Brazilian HIV population","volume":"48","author":"Troncoso","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.bjid.2016.09.006_bib0350","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ana.21225","article-title":"Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy","volume":"63","author":"Bhaskaran","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0355","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/486960","article-title":"Prevalence and Correlates of HIV-Associated Neurocognitive Disorders (HAND) in Northwestern Nigeria","author":"Yakasai","year":"2015","journal-title":"Neurol Res Int"},{"key":"10.1016\/j.bjid.2016.09.006_bib0365","doi-asserted-by":"crossref","DOI":"10.1111\/j.1468-1293.2012.01043.x","article-title":"Predictors of symptomatic HIV-associated neurocognitive disorders in universal health care","volume":"14","author":"McCombe","year":"2013","journal-title":"HIV Med"},{"key":"10.1016\/j.bjid.2016.09.006_bib0370","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/13550280390194109","article-title":"Human immunodeficiency virus-associated dementia: an evolving disease","volume":"9","author":"McArthur","year":"2003","journal-title":"J Neurovirol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0375","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","article-title":"Updated research nosology for HIV-associated neurocognitive disorders","volume":"69","author":"Antinori","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0380","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1212\/01.WNL.0000134665.58343.8D","article-title":"Higher frequency of dementia in older HIV-1 individuals. The Hawaii aging with HIV-1 cohort","volume":"63","author":"Valcour","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0385","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/13550280701258423","article-title":"Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals","volume":"13","author":"Sacktor","year":"2007","journal-title":"J Neurovirol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0390","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00234-011-0854-2","article-title":"Factors affecting brain structure in men with HIV disease in the post-HAART era","volume":"54","author":"Becker","year":"2012","journal-title":"Neuroradiology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0395","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/QAI.0b013e318249db17","article-title":"Independent effects of HIV, aging, and HAART on brain volumetric measures","volume":"59","author":"Ances","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.bjid.2016.09.006_bib0400","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/13803395.2014.892061","article-title":"Verbal memory declines more rapidly with age in HIV infected versus uninfected adults","volume":"36","author":"Seider","year":"2014","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0405","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s10461-012-0229-7","article-title":"Lower cognitive reserve among individuals with syndromic HIV-associated neurocognitive disorders (HAND)","volume":"16","author":"Morgan","year":"2012","journal-title":"AIDS Behav"},{"key":"10.1016\/j.bjid.2016.09.006_bib0410","unstructured":"World Alzheimer Report 2015: The Global Impact of Dementia. http:\/\/www.alz.co.uk\/research\/world-report-2015."},{"key":"10.1016\/j.bjid.2016.09.006_bib0415","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000109800","article-title":"Epidemiology of vascular dementia","volume":"14","author":"H\u00e9bert","year":"1995","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0420","first-page":"S4","article-title":"Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group","volume":"54","author":"Lobo","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.bjid.2016.09.006_bib0425","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1034\/j.1600-0447.2002.01417.x","article-title":"Mild cognitive impairment \u2013 a review of prevalence, incidence and outcome according to current approaches","volume":"106","author":"Bischkopf","year":"2002","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.bjid.2016.09.006_bib0430","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1034\/j.1600-0404.2003.00118.x","article-title":"Mild cognitive impairment: prevalence and predictive validity according to current approaches","volume":"108","author":"Busse","year":"2003","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.bjid.2016.09.006_bib0435","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1590\/S0004-282X2005000200003","article-title":"Prevalence of cognitive and functional impairment in community-dwelling elderly. Importance of evaluating activities of daily living","volume":"63","author":"Laks","year":"2005","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.bjid.2016.09.006_bib0440","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000112554","article-title":"Prevalence of cognitive and functional impairment in a community sample from S\u00e3o Paulo, Brazil","volume":"25","author":"Hototian","year":"2008","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.bjid.2016.09.006_bib0445","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/gps.1737","article-title":"Prevalence of cognitive and functional impairment in a community sample in Ribeir\u00e3o Preto, Brazil","volume":"22","author":"Lopes","year":"2007","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.bjid.2016.09.006_bib0450","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7326\/0003-4819-133-1-200007040-00004","article-title":"Adherence to protease inhibitor therapy and outcomes in patients with HIV infection","volume":"133","author":"Paterson","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bjid.2016.09.006_bib0455","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1037\/0278-6133.26.1.40","article-title":"Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status","volume":"26","author":"Barclay","year":"2007","journal-title":"Health Psychol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0460","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.qai.0000248354.63748.54","article-title":"Relationship between antiretroviral prescribing patterns and treatment guidelines in treatment-naive HIV-1 infected US veterans (1992\u20132004)","volume":"44","author":"Holodniy","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.bjid.2016.09.006_bib0465","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s40266-013-0107-7","article-title":"Aging, antiretrovirals, and adherence: a meta analysis of adherence among older HIV-infected individuals","volume":"30","author":"Ghidei","year":"2013","journal-title":"Drugs Aging"},{"key":"10.1016\/j.bjid.2016.09.006_bib0470","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10461-011-9973-3","article-title":"Depression and neurocognitive performance in Portuguese patients infected with HIV","volume":"15","author":"Bragan\u00e7a","year":"2011","journal-title":"AIDS Behav"},{"key":"10.1016\/j.bjid.2016.09.006_bib0475","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10461-006-9142-2","article-title":"Depression and CD4 cell count among persons with HIV infection in Uganda","volume":"10","author":"Kaharuza","year":"2006","journal-title":"AIDS Behav"},{"key":"10.1016\/j.bjid.2016.09.006_bib0480","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1590\/S1516-44462012000200008","article-title":"Depressive symptoms in HIV-infected patients treated with highly active antiretroviral therapy","volume":"34","author":"Silveira","year":"2012","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.bjid.2016.09.006_bib0485","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1080\/09540121.2014.913767","article-title":"High prevalence of suicide risk in people living with HIV: who is at higher risk?","volume":"26","author":"Passos","year":"2014","journal-title":"AIDS Care"},{"key":"10.1016\/j.bjid.2016.09.006_bib0490","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0895-4356(01)00446-2","article-title":"Neuropsychiatric aspects of HIV infection among older adults","volume":"54","author":"Hinkin","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.bjid.2016.09.006_bib0495","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/09540121.2013.841842","article-title":"Depressive symptoms, self-esteem, HIV symptom management self-efficacy and self-compassion in people living with HIV","volume":"26","author":"Eller","year":"2014","journal-title":"AIDS Care"},{"key":"10.1016\/j.bjid.2016.09.006_bib0500","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1590\/0004-282X20130042","article-title":"Validity of the international HIV dementia scale in Brazil","volume":"71","author":"Rodrigues","year":"2013","journal-title":"Arq Neuropsiquiatr"}],"container-title":["The Brazilian Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413867016303853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413867016303853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T08:56:08Z","timestamp":1536310568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1413867016303853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1413867016303853"],"URL":"https:\/\/doi.org\/10.1016\/j.bjid.2016.09.006","relation":{},"ISSN":["1413-8670"],"issn-type":[{"value":"1413-8670","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals","name":"articletitle","label":"Article Title"},{"value":"The Brazilian Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjid.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}