{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:09:43Z","timestamp":1790402983269,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Brazilian Journal of Infectious Diseases"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.bjid.2021.101701","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:11:24Z","timestamp":1640045484000},"page":"101701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-2630","authenticated-orcid":false,"given":"Chien-Chou","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-4079","authenticated-orcid":false,"given":"Wei-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6152-4885","authenticated-orcid":false,"given":"Shih-Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjid.2021.101701_bib0001","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJM200511243532123","article-title":"Mitochondrial toxicity associated with linezolid","volume":"353","author":"Soriano","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjid.2021.101701_bib0002","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2165\/00003088-200342130-00004","article-title":"Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial","volume":"42","author":"Stalker","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.bjid.2021.101701_bib0003","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00687-17","article-title":"Systematic therapeutic drug monitoring for linezolid: variability and clinical impact","volume":"61","author":"Galar","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bjid.2021.101701_bib0004","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1128\/AAC.47.9.2775-2780.2003","article-title":"Pharmacokinetics of linezolid in subjects with renal dysfunction","volume":"47","author":"Brier","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bjid.2021.101701_bib0005","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ijantimicag.2013.02.020","article-title":"Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections","volume":"41","author":"Cattaneo","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bjid.2021.101701_bib0006","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s10156-010-0080-6","article-title":"Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction","volume":"17","author":"Tsuji","year":"2011","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.bjid.2021.101701_bib0007","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/jcpt.13245","article-title":"Linezolid and the risk of lactic acidosis: data mining and analysis of the FDA adverse event reporting system","volume":"45","author":"Dai","year":"2020","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.bjid.2021.101701_bib0008","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/cir842","article-title":"Systemic antibiotic therapy for chronic osteomyelitis in adults","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bjid.2021.101701_bib0009","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00228-017-2377-1","article-title":"Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors","volume":"74","author":"Mori","year":"2018","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.bjid.2021.101701_bib0010","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/14740338.2017.1335305","article-title":"Linezolid-induced lactic acidosis: the thin line between bacterial and mitochondrial ribosomes","volume":"16","author":"Santini","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.bjid.2021.101701_bib0011","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2215\/CJN.00340118","article-title":"Clinical pharmacokinetics in kidney disease: Fundamental principles","volume":"13","author":"Lea-Henry","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.bjid.2021.101701_bib0012","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1080\/14656566.2016.1182154","article-title":"Risk factors associated with high linezolid trough plasma concentrations","volume":"17","author":"Morata","year":"2016","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.bjid.2021.101701_bib0013","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/bcpt.12797","article-title":"10-Year experience of therapeutic drug monitoring (TDM) of linezolid in a hospital-wide population of patients receiving conventional dosing: is there enough evidence for suggesting TDM in the majority of patients?","volume":"121","author":"Pea","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.bjid.2021.101701_bib0014","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00605-19","article-title":"Reappraisal of linezolid dosing in renal impairment to improve safety","volume":"63","author":"Crass","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bjid.2021.101701_bib0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijid.2014.12.009","article-title":"Incidence and risk factors of linezolid- induced lactic acidosis","volume":"31","author":"Im","year":"2015","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.bjid.2021.101701_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111631","article-title":"In linezolid underexposure, pharmacogenetics matters: The role of CYP3A5","volume":"139","author":"Cheli","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bjid.2021.101701_bib0017","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1183\/09031936.00001913","article-title":"Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients","volume":"42","author":"Bolhuis","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1016\/j.bjid.2021.101701_bib0018","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2165\/11539220-000000000-00000","article-title":"The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients","volume":"50","author":"Ulldemolins","year":"2011","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.bjid.2021.101701_bib0019","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ijantimicag.2014.06.017","article-title":"Early lactic acidosis associated with linezolid therapy in paediatric patients","volume":"44","author":"Ozkaya-Parlakay","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bjid.2021.101701_bib0020","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1517\/17425255.2016.1166204","article-title":"Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones","volume":"12","author":"Cattaneo","year":"2016","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.bjid.2021.101701_bib0021","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1097\/01.CCM.0000147687.06808.92","article-title":"Removal of linezolid by conventional intermittent hemodialysis, sustained low- efficiency dialysis, or continuous venovenous hemofiltration in patients with acute renal failure","volume":"32","author":"Fiaccadori","year":"2004","journal-title":"Crit Care Med"}],"container-title":["The Brazilian Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413867021001707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413867021001707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:57:07Z","timestamp":1761407827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1413867021001707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1413867021001707"],"URL":"https:\/\/doi.org\/10.1016\/j.bjid.2021.101701","relation":{},"ISSN":["1413-8670"],"issn-type":[{"value":"1413-8670","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function","name":"articletitle","label":"Article Title"},{"value":"The Brazilian Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjid.2021.101701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Sociedade Brasileira de Infectologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101701"}}