{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:06:37Z","timestamp":1773662797254,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bjoms.2016.01.013","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T09:32:14Z","timestamp":1453973534000},"page":"275-279","source":"Crossref","is-referenced-by-count":24,"title":["Radioprotective effects of lycopene and curcumin during local irradiation of parotid glands in Sprague Dawley rats"],"prefix":"10.1016","volume":"54","author":[{"given":"Pia","family":"Lopez-Jornet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"G\u00f3mez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Garc\u00eda Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezkai","family":"Valle-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Xerafin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Vicente-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2016.01.013_bib0130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/154411130301400305","article-title":"Oral sequelae of head and neck radiotherapy","volume":"14","author":"Vissink","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/10520290802374683","article-title":"On approaches to the functional restoration of salivary glands damaged by radiation therapy for head and neck cancer, with a review of related aspects of salivary gland morphology and development","volume":"83","author":"Redman","year":"2008","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0140","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/sj.mt.6300296","article-title":"Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands","volume":"15","author":"Cotrim","year":"2007","journal-title":"Mol Ther"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0145","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/lary.23609","article-title":"Protective effects of resveratrol on salivary gland damage induced by total body irradiation in rats","volume":"122","author":"\u015eim\u015fek","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(03)00149-5","article-title":"Protection against ionizing radiation by antioxidant nutrients and phytochemicals","volume":"189","author":"Weiss","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0155","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","article-title":"Free radicals, antioxidants, and nutrition","volume":"18","author":"Fang","year":"2002","journal-title":"Nutrition"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0160","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1177\/0022034509343143","article-title":"Sensitivity of salivary glands to radiation: From animal models to therapies","volume":"88","author":"Grundmann","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.archoralbio.2005.06.008","article-title":"Evaluation of radioprotective effect of vitamin E in salivary dysfunction in irradiated rats","volume":"51","author":"Ramos","year":"2006","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0170","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies","volume":"23","author":"Aggarwal","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0175","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1034\/j.1601-0825.2002.02838.x","article-title":"The enigmatic mechanism of irradiation-induced damage to the major salivary glands","volume":"8","author":"Nagler","year":"2002","journal-title":"Oral Dis"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0180","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-0-387-46401-5_13","article-title":"Radioprotection and radiosensitization by curcumin","volume":"595","author":"Jagetia","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0185","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/lary.20582","article-title":"Curcumin: a potential radio-enhancer in head and neck cancer","volume":"119","author":"Khafif","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0190","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/ars.2007.1769","article-title":"Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials","volume":"10","author":"Strimpakos","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0195","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0200","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/carcin\/21.10.1835","article-title":"Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats","volume":"21","author":"Inano","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0205","first-page":"431","article-title":"Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity","volume":"17","author":"Thresiamma","year":"1998","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0210","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.otohns.2004.09.006","article-title":"Curcumin: a new radio-sensitizer of squamous cell carcinoma cells","volume":"132","author":"Khafif","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0215","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/odi.12025","article-title":"Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells","volume":"19","author":"Camacho-Alonso","year":"2013","journal-title":"Oral Dis"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0220","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bbagen.2006.11.008","article-title":"Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro","volume":"1770","author":"Srinivasan","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0225","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tox.2009.05.004","article-title":"Lycopene: an antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes","volume":"262","author":"Srinivasan","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3835(00)00401-8","article-title":"Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat","volume":"154","author":"Breinholt","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0235","first-page":"386","article-title":"Lycopene as a carotenoid provides radioprotectant and antioxidant effects by quenching radiation-induced free radical singlet oxygen: an overview","volume":"16","author":"Pirayesh Islamian","year":"2015","journal-title":"Cell J"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0240","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1177\/147323001103900412","article-title":"Protective effect of lycopene against radiation-induced hepatic toxicity in rats","volume":"39","author":"Meydan","year":"2011","journal-title":"J Int Med Res"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0245","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.2353\/ajpath.2006.060327","article-title":"Radioprotective effect of heat shock protein 25 on submandibular glands of rats","volume":"169","author":"Lee","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bjoms.2016.01.013_bib0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0964-1955(96)00040-1","article-title":"Ultrastructural morphometry of parotid acinar cells following fractionated irradiation","volume":"330","author":"Grehn","year":"1997","journal-title":"Oral Oncol"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435616000152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435616000152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T18:54:35Z","timestamp":1537037675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435616000152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0266435616000152"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2016.01.013","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}