{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:53:49Z","timestamp":1790744029291,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC81672659"],"award-info":[{"award-number":["NSFC81672659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC81472523"],"award-info":[{"award-number":["NSFC81472523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC31560265"],"award-info":[{"award-number":["NSFC31560265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangzhou Science and Technology","award":["201605131226218"],"award-info":[{"award-number":["201605131226218"]}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["2015A030313017"],"award-info":[{"award-number":["2015A030313017"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["S2012010008665"],"award-info":[{"award-number":["S2012010008665"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjoms.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.bjoms.2020.01.028","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T18:42:24Z","timestamp":1582828944000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of a potential target for treatment of squamous cell carcinoma of the tongue: follistatin"],"prefix":"10.1016","volume":"58","author":[{"given":"M.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2020.01.028_bib0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO;2-3","article-title":"Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?","volume":"20","author":"Byers","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CMENT.S19874","article-title":"Selective neck dissection (IIa, III): a rational replacement for extended supraomohyoid neck dissection in patients with N0 supraglottic and glottic squamous cell carcinoma","volume":"8","author":"Zohdi","year":"2015","journal-title":"Clin Med Insights Ear Nose Throat"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0015","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/cncr.23278","article-title":"Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection","volume":"112","author":"Huang","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0020","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/000164800750061615","article-title":"Is extended selective supraomohyoid neck dissection indicated for treatment of oral cancer with clinically negative neck?","volume":"120","author":"Ferlito","year":"2000","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0025","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.oraloncology.2010.06.006","article-title":"Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I)","volume":"46","author":"Bello","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0030","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1056\/NEJMe030009","article-title":"Imatinib mesylate\u2014the new gold standard for treatment of chronic myeloid leukemia","volume":"348","author":"Peggs","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMoa020150","article-title":"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta","volume":"347","author":"Apperley","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0040","first-page":"2829","article-title":"Lentivirus-mediated silencing of HOTAIR lncRNA restores gefitinib sensitivity by activating Bax\/Caspase-3 and suppressing TGF-alpha\/EGFR signaling in lung adenocarcinoma","volume":"15","author":"Liu","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0045","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/btpr.2564","article-title":"Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro","volume":"34","author":"Li","year":"2018","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17121998","article-title":"Enhancing anticancer effect of gefitinib across the blood-brain barrier model using liposomes modified with one alpha-helical cell-penetrating peptide or glutathione and Tween 80","volume":"17","author":"Lin","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0055","unstructured":"Gene expression omnibus. Available from IRL: https:\/\/www.ncbi.nlm.nih.gov\/gds. Last accessed 28 January 2020."},{"key":"10.1016\/j.bjoms.2020.01.028_bib0060","doi-asserted-by":"crossref","first-page":"61786","DOI":"10.18632\/oncotarget.18692","article-title":"Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation","volume":"8","author":"Enokida","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0065","doi-asserted-by":"crossref","first-page":"e9317","DOI":"10.1371\/journal.pone.0009317","article-title":"Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations","volume":"5","author":"Tuch","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2407-9-11","article-title":"Oral tongue cancer gene expression profiling: identification of novel potential prognosticators by oligonucleotide microarray analysis","volume":"9","author":"Estilo","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2164-9-69","article-title":"Transcriptomic dissection of tongue squamous cell carcinoma","volume":"9","author":"Ye","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0080","unstructured":"Cancer genome atlas. Available from URL: https:\/\/cancergenome.nih.gov\/. Last accessed 6 February 2020."},{"key":"10.1016\/j.bjoms.2020.01.028_bib0085","unstructured":"Gene ontology. Available from URL: Geneontology.org. Last accessed 29 January 2020."},{"key":"10.1016\/j.bjoms.2020.01.028_bib0090","unstructured":"Kyoto encyclopedia of genes and genomes. Available from URL: https:\/\/www.genome.jp\/kegg\/mapper.html. Last accessed 6 February 2020."},{"key":"10.1016\/j.bjoms.2020.01.028_bib0095","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fgene.2019.00421","article-title":"DiVenn: an interactive and integrated web-based visualization tool for comparing gene lists","volume":"10","author":"Sun","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0100","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","author":"The Cancer Genome Atlas Network","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.omtn.2019.03.012","article-title":"miR-31-5p is a potential circulating biomarker and therapeutic target for oral cancer","volume":"16","author":"Lu","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.oraloncology.2016.03.017","article-title":"microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection","volume":"57","author":"He","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00439-010-0915-3","article-title":"Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma","volume":"129","author":"Jiang","year":"2011","journal-title":"Hum Genet"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0125","doi-asserted-by":"crossref","first-page":"37753","DOI":"10.1074\/jbc.M110.122804","article-title":"Experimental validation of the predicted binding site of Escherichia coli K1 outer membrane protein A to human brain microvascular endothelial cells: identification of critical mutations that prevent E. coli meningitis","volume":"285","author":"Pascal","year":"2010","journal-title":"J Biol Chem"},{"issue":"Suppl. 1","key":"10.1016\/j.bjoms.2020.01.028_bib0130","first-page":"72","article-title":"Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect","volume":"16","author":"Rappaport","year":"2017","journal-title":"Biomed Eng"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0135","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw030","article-title":"Genic insights from integrated human proteomics in GeneCards","author":"Fishilevich","year":"2016","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0140","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1210\/endo.140.11.7141","article-title":"Expression of activin A and follistatin core proteins by human prostate tumor cell lines","volume":"140","author":"McPherson","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mce.2004.07.011","article-title":"Activin: an important regulator of wound repair, fibrosis, and neuroprotection","volume":"225","author":"Sulyok","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0150","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0898-6568(00)00099-1","article-title":"Difference between follistatin isoforms in the inhibition of activin signalling: activin neutralizing activity of follistatin isoforms is dependent on their affinity for activin","volume":"12","author":"Hashimoto","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0155","doi-asserted-by":"crossref","first-page":"15930","DOI":"10.1074\/jbc.M700737200","article-title":"Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions","volume":"282","author":"Lerch","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bjoms.2020.01.028_bib0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrm2221","article-title":"Filling out the Hippo pathway","volume":"8","author":"Saucedo","year":"2007","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435620300322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435620300322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:26:51Z","timestamp":1759418811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435620300322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0266435620300322"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2020.01.028","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a potential target for treatment of squamous cell carcinoma of the tongue: follistatin","name":"articletitle","label":"Article Title"},{"value":"British Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjoms.2020.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}