{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:28:09Z","timestamp":1793140089481,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bjoms.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.bjoms.2021.09.006","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T21:29:06Z","timestamp":1631741346000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Radiotherapy and the survival of dental implants: a systematic review"],"prefix":"10.1016","volume":"60","author":[{"given":"Bizhan","family":"Shokouhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Cerajewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2021.09.006_b0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bjoms.2021.09.006_b0010","series-title":"World cancer report 2014","year":"2014"},{"key":"10.1016\/j.bjoms.2021.09.006_b0015","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.4317\/medoral.18772","article-title":"Oral cancer: current role of radiotherapy and chemotherapy","volume":"18","author":"Huang","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.bjoms.2021.09.006_b0020","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1634\/theoncologist.2009-0289","article-title":"Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis","volume":"15","author":"Pulte","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.bjoms.2021.09.006_b0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cncr.23206","article-title":"Adjuvant radiotherapy improves overall survival for patients with lymph node-positive head and neck squamous cell carcinoma","volume":"112","author":"Lavaf","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bjoms.2021.09.006_b0030","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1748-717X-7-84","article-title":"Follow up after IMRT in oral cavity cancer: update","volume":"7","author":"Studer","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0035","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/ijc.20740","article-title":"Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database","volume":"114","author":"Carvalho","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bjoms.2021.09.006_b0040","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(06)70580-0","article-title":"Oral complications of radiotherapy","volume":"7","author":"Sciubba","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40729-018-0131-9","article-title":"Survival of dental implants placed in autogenous bone grafts and bone flaps in head and neck oncology patients: a systematic review","volume":"4","author":"Laverty","year":"2018","journal-title":"Int J Implant Dent"},{"issue":"9","key":"10.1016\/j.bjoms.2021.09.006_b0050","first-page":"CD003603","article-title":"Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants","volume":"2013","author":"Esposito","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjoms.2021.09.006_b0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ijrobp.2019.02.044","article-title":"HOPON (hyperbaric oxygen for the prevention of osteoradionecrosis): a randomized controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible after dentoalveolar surgery","volume":"104","author":"Shaw","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bjoms.2021.09.006_b0060","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.jcms.2016.07.016","article-title":"Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: a prospective observational study on implant survival and quality of life- preliminary results","volume":"44","author":"Ettl","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0065","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bjoms.2014.05.013","article-title":"Overdentures on primary mandibular implants in patients with oral cancer: a follow-up study over 14 years","volume":"52","author":"Korfage","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6831-15-5","article-title":"Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study","volume":"15","author":"Pompa","year":"2015","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.bjoms.2021.09.006_b0075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/SCS.0b013e318207b59b","article-title":"Implant therapy in irradiated patients","volume":"22","author":"Sammartino","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0080","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ijom.2006.03.007","article-title":"Effect of postoperative radiotherapy on the functional result of implants placed during ablative surgery for oral cancer","volume":"35","author":"Schepers","year":"2006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0085","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1177\/154405910208101212","article-title":"A clinical evaluation of implants in irradiated oral cancer patients","volume":"81","author":"Visch","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.bjoms.2021.09.006_b0090","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/028418698430061","article-title":"Osseointegration of dental implants in patients with and without radiotherapy","volume":"37","author":"Wagner","year":"1998","journal-title":"Acta Oncol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0095","first-page":"17","article-title":"Infectious diseases of the jaws","volume":"28","author":"Meyer","year":"1970","journal-title":"J Oral Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2021.09.006_b0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2004.08.021","article-title":"The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway","volume":"73","author":"Delanian","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0110","doi-asserted-by":"crossref","unstructured":"Delanian S, Lefaix JL, eds. Current management for late normal tissue injury: radiation-induced fibrosis and necrosis. Semin Radiat Oncol 2007; 17:99\u2013107.","DOI":"10.1016\/j.semradonc.2006.11.006"},{"key":"10.1016\/j.bjoms.2021.09.006_b0115","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/154411130301400407","article-title":"Implants in the medically compromised patient","volume":"14","author":"Beikler","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"issue":"Suppl 6","key":"10.1016\/j.bjoms.2021.09.006_b0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0501.2012.02547.x","article-title":"Systematic review of the survival rate and the incidence of biological, technical, and aesthetic complications of single crowns on implants reported in longitudinal studies with a mean follow-up of 5 years","volume":"23","author":"Jung","year":"2012","journal-title":"Clin Oral Implants Res"},{"issue":"Suppl 6","key":"10.1016\/j.bjoms.2021.09.006_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0501.2012.02546.x","article-title":"A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years","volume":"23","author":"Pjetursson","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2021.09.006_b0130","first-page":"365","article-title":"Long-term results of mandibular implants supporting an overdenture: implant survival, failures, and crestal bone level changes","volume":"26","author":"Ueda","year":"2011","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2021.09.006_b0135","series-title":"On bone behaviour after irradiation","author":"Jacobsson","year":"1985"},{"key":"10.1016\/j.bjoms.2021.09.006_b0140","first-page":"1142","article-title":"A study of irradiated bone: I. Histopathologic and physiologic changes","volume":"20","author":"King","year":"1979","journal-title":"J Nucl Med"},{"key":"10.1016\/j.bjoms.2021.09.006_b0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0030-4220(87)90136-8","article-title":"Studies in the radiobiology of osteoradionecrosis and their clinical significance","volume":"64","author":"Marx","year":"1987","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/ID.0b013e31827e84ee","article-title":"The influence of radiation therapy on dental implantology","volume":"22","author":"Anderson","year":"2013","journal-title":"Implant Dent"},{"issue":"Suppl 1","key":"10.1016\/j.bjoms.2021.09.006_b0155","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.4103\/0973-1482.92220","article-title":"Dental implants in irradiated jaws: a literature review","volume":"8","author":"Dholam","year":"2012","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.bjoms.2021.09.006_b0160","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.oraloncology.2010.10.004","article-title":"Implant survival rate after oral cancer therapy: a review","volume":"46","author":"Javed","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjoms.2021.09.006_b0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1600-0501.1998.090103.x","article-title":"Osseointegration of dental implants in bone irradiated with 40, 50 or 60 Gy doses. An experimental study with beagle dogs","volume":"9","author":"Asikainen","year":"1998","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2021.09.006_b0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0501.2007.01457.x","article-title":"Implant stability during osseointegration in irradiated and non-irradiated minipig alveolar bone: an experimental study","volume":"19","author":"Verdonck","year":"2008","journal-title":"Clin Oral Implants Res"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435621003363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435621003363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:30:37Z","timestamp":1759419037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435621003363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0266435621003363"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2021.09.006","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiotherapy and the survival of dental implants: a systematic review","name":"articletitle","label":"Article Title"},{"value":"British Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjoms.2021.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2021 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons. All rights reserved.","name":"copyright","label":"Copyright"}]}}