{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:10:34Z","timestamp":1784239834314,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjoms.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bjoms.2024.08.008","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:04:21Z","timestamp":1725627861000},"page":"899-908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Management of Medication-Related Osteonecrosis of the Jaw: An Overview of National and International Guidelines"],"prefix":"10.1016","volume":"62","author":[{"given":"Nikul","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Seoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2024.08.008_b0005","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0010","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bjoms.2020.03.010","article-title":"Medication-related osteonecrosis of the jaws and quality of life: review and structured analysis","volume":"58","author":"Murphy","year":"2020","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0015","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0020","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jcms.2017.05.028","article-title":"What is the effect of anti-resorptive drugs (ARDs) on the development of medication-related osteonecrosis of the jaw (MRONJ) in osteoporosis patients: a systematic review","volume":"45","author":"Aljohani","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0025","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/odi.12708","article-title":"Risk factors for medication-related osteonecrosis of the jaws: a systematic review","volume":"24","author":"McGowan","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.bjoms.2024.08.008_b0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.oooo.2018.11.012","article-title":"Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review","volume":"127","author":"King","year":"2019","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/RCT.0b013e31817e4986","article-title":"Imaging findings of bisphosphonate-related osteonecrosis of the jaw with emphasis on early magnetic resonance imaging findings","volume":"33","author":"Krishnan","year":"2009","journal-title":"J Comput Assist Tomogr"},{"issue":"12","key":"10.1016\/j.bjoms.2024.08.008_b0040","article-title":"The role of the immune response in the development of medication-related osteonecrosis of the jaw","volume":"25","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0045","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fcimb.2019.00282","article-title":"Commensal and pathogenic biofilms alter toll-like receptor signaling in reconstructed human gingiva","volume":"9","author":"Shang","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0050","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/medicina57050463","article-title":"Infection as an important factor in medication-related osteonecrosis of the jaw (MRONJ)","volume":"57","author":"Otto","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.bjoms.2024.08.008_b0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.oooo.2018.09.008","article-title":"Medication-related osteonecrosis of the jaw: definition and best practice for prevention, diagnosis, and treatment","volume":"127","author":"Nicolatou-Galitis","year":"2019","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0060","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.oraloncology.2018.08.003","article-title":"Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: a systematic review with meta-analyses","volume":"85","author":"Karna","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"M. Medication-related osteonecrosis of the jaw: prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bjoms.2024.08.008_b0070","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","volume":"10","author":"Beth-Tasdogan","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjoms.2024.08.008_b0075","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.coms.2015.06.003","article-title":"The frequency of medication-related osteonecrosis of the jaw and its associated risk factors","volume":"27","author":"Dodson","year":"2015","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.bjoms.2024.08.008_b0080","first-page":"e326","article-title":"Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid: a systematic review and meta-analysis","volume":"25","author":"Limones","year":"2020","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.bjoms.2024.08.008_b0085","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14219\/jada.archive.2010.0082","article-title":"The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program","volume":"141","author":"Grbic","year":"2010","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.bjoms.2024.08.008_b0090","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1017\/S0022215116000414","article-title":"Restorative dentistry and oral rehabilitation: United Kingdom national multidisciplinary guidelines","volume":"130","author":"Butterworth","year":"2016","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0095","article-title":"Interventions for managing medication-related osteonecrosis of the jaw","volume":"10","author":"Beth-Tasdogan","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjoms.2024.08.008_b0100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2334\/josnusd.21-0016","article-title":"Lack of evidence in reducing risk of MRONJ after teeth extractions with systemic antibiotics","volume":"63","author":"Cabras","year":"2021","journal-title":"J Oral Sci"},{"key":"10.1016\/j.bjoms.2024.08.008_b0105","unstructured":"Faculty of General Dental Practitioners 2020. Antimicrobial Prescribing in dentistry | FGDP. Available from URL: <https:\/\/www.fgdp.org.uk\/antimicrobial-prescribing> (last accessed 24 September 2024)."},{"key":"10.1016\/j.bjoms.2024.08.008_b0110","unstructured":"Scottish Dental Clinical Effectiveness Programme 2016. Drug Prescribing for Dentistry Dental Clinical Guideline. Available from URL: <https:\/\/www.sdcep.org.uk\/published-guidance\/drug-prescribing\/> (last accessed 24 September 2024)."},{"key":"10.1016\/j.bjoms.2024.08.008_b0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jop.12963","article-title":"Association between periodontitis and medication-related osteonecrosis of the jaw: a systematic review and meta-analysis","volume":"49","author":"Lorenzo-Pouso","year":"2020","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.bjoms.2024.08.008_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/719478","article-title":"The \u201cCROMa\u201d project: a care pathway for clinical management of patients with bisphosphonate exposure","volume":"2014","author":"Capocci","year":"2014","journal-title":"Int J Dent"},{"key":"10.1016\/j.bjoms.2024.08.008_b0125","doi-asserted-by":"crossref","DOI":"10.1259\/dmfr.20160065","article-title":"Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw?","volume":"45","author":"Klingelh\u00f6ffer","year":"2016","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0130","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1007\/s00784-020-03423-0","article-title":"Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review","volume":"24","author":"Moreno-Rabi\u00e9","year":"2020","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bjoms.2024.08.008_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03795","article-title":"Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): a systematic review","volume":"6","author":"Ottesen","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.bjoms.2024.08.008_b0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.oooo.2021.06.003","article-title":"Tooth extractions in patients with cancer receiving high-dose antiresorptive medication: a randomized clinical feasibility trial of drug holiday versus drug continuation","volume":"133","author":"Ottesen","year":"2022","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0145","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00198-021-05995-3","article-title":"Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study","volume":"32","author":"Hasegawa","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bjoms.2024.08.008_b0150","doi-asserted-by":"crossref","first-page":"17226","DOI":"10.1038\/s41598-021-96480-8","article-title":"Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients","volume":"11","author":"Soutome","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.bjoms.2024.08.008_b0155","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/antibiotics10020195","article-title":"Conservative management of medication-related osteonecrosis of the jaws (MRONJ): a retrospective cohort study","volume":"10","author":"Varoni","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.bjoms.2024.08.008_b0160","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.adaj.2017.04.002","article-title":"Effectiveness of treatments for medication-related osteonecrosis of the jaw: a systematic review and meta-analysis","volume":"148","author":"El-Rabbany","year":"2017","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.bjoms.2024.08.008_b0165","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcms.2020.02.017","article-title":"Medication-related osteonecrosis of the jaw (MRONJ) stage III: conservative and conservative surgical approaches versus an aggressive surgical intervention: a systematic review","volume":"48","author":"Vanpoecke","year":"2020","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0170","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.oooo.2021.09.009","article-title":"Surgical vs conservative treatment of medication-related osteonecrosis of the jaw: a complex systematic review and meta-analysis","volume":"132","author":"Lobekk","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0175","doi-asserted-by":"crossref","DOI":"10.1038\/srep31604","article-title":"The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection","volume":"6","author":"Russmueller","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bjoms.2024.08.008_b0180","article-title":"Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ)","volume":"2","author":"Rollason","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bjoms.2024.08.008_b0185","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.oooo.2016.11.011","article-title":"Bacterial diversity in medication-related osteonecrosis of the jaw","volume":"123","author":"Hallmer","year":"2017","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0190","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s00784-018-2655-z","article-title":"Microbial diversity in infections of patients with medication-related osteonecrosis of the jaw","volume":"23","author":"Zirk","year":"2019","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bjoms.2024.08.008_b0195","first-page":"e43","article-title":"Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphosphonates","volume":"22","author":"Berm\u00fadez-Bejarano","year":"2017","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.bjoms.2024.08.008_b0200","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00784-020-03595-9","article-title":"Retrospective analysis of bacterial colonization of necrotic bone and antibiotic resistance in 98 patients with medication-related osteonecrosis of the jaw (MRONJ)","volume":"25","author":"Ewald","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bjoms.2024.08.008_b0205","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1200\/JCO.19.02192","article-title":"Teriparatide promotes bone healing in medication-related osteonecrosis of the jaw: a placebo-controlled, randomized trial","volume":"38","author":"Sim","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bjoms.2024.08.008_b0210","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s00198-021-06078-z","article-title":"Is teriparatide therapy effective for medication-related osteonecrosis of the jaw? a systematic review and meta-analysis","volume":"32","author":"Dos Santos","year":"2021","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.bjoms.2024.08.008_b0215","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jcms.2020.09.008","article-title":"Pentoxifylline and tocopherol protocol to treat medication-related osteonecrosis of the jaw: a systematic literature review","volume":"48","author":"Cavalcante","year":"2020","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjoms.2024.08.008_b0220","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.amjmed.2010.04.033","article-title":"Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: a case series","volume":"123","author":"Fedele","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.bjoms.2024.08.008_b0225","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5125\/jkaoms.2014.40.5.206","article-title":"Drug holiday as a prognostic factor of medication-related osteonecrosis of the jaw","volume":"40","author":"Kim","year":"2014","journal-title":"J Korean Assoc Oral Maxillofac Surg"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435624002316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435624002316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:37:34Z","timestamp":1733999854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435624002316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0266435624002316"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2024.08.008","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Medication-Related Osteonecrosis of the Jaw: An Overview of National and International Guidelines","name":"articletitle","label":"Article Title"},{"value":"British Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjoms.2024.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2024 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons.","name":"copyright","label":"Copyright"}]}}