{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:47:09Z","timestamp":1787669229736,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bjoms.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bjoms.2025.01.003","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:57:28Z","timestamp":1736380648000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is there any relation between proton pump inhibitors and risk of dental implant failure? A large-scale retrospective study using the BigMouth repository"],"prefix":"10.1016","volume":"63","author":[{"given":"Georgios S.","family":"Chatzopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry F.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2025.01.003_b0005","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period","volume":"16","author":"Br\u00e5nemark","year":"1977","journal-title":"Scand J Plast Reconstr Surg Suppl"},{"key":"10.1016\/j.bjoms.2025.01.003_b0010","first-page":"150","article-title":"Consensus statements and recommended clinical procedures regarding implant survival and complications","volume":"19","author":"Lang","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2025.01.003_b0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1600-0501.2004.01120.x","article-title":"A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years","volume":"15","author":"Pjetursson","year":"2004","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0020","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1600-0501.2009.01750.x","article-title":"Clinical and radiographic study of implant treatment outcome in periodontally susceptible and non-susceptible patients: a prospective long-term study","volume":"20","author":"De Boever","year":"2009","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/JPER.18-0338","article-title":"Outcome of early dental implant placement versus other dental implant placement protocols: a systematic review and meta-analysis","volume":"90","author":"Bassir","year":"2019","journal-title":"J Periodontol"},{"key":"10.1016\/j.bjoms.2025.01.003_b0030","doi-asserted-by":"crossref","first-page":"44S","DOI":"10.1177\/0022034514563077","article-title":"Effectiveness of implant therapy analyzed in a Swedish population: early and late implant loss","volume":"94","author":"Derks","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0035","first-page":"71","article-title":"In patients requiring single-tooth replacement, what are the outcomes of implant- as compared to tooth-supported restorations?","volume":"22","author":"Salinas","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2025.01.003_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bone.2012.09.011","article-title":"Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation","volume":"52","author":"Bonsignore","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bjoms.2025.01.003_b0045","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1111\/febs.12478","article-title":"Dose-dependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity","volume":"280","author":"Costa-Rodrigues","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.bjoms.2025.01.003_b0050","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jcpe.12506","article-title":"Systemic administration of omeprazole interferes with bone healing and implant osseointegration: an in vivo study on rat tibiae","volume":"43","author":"Al Subaie","year":"2016","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.bjoms.2025.01.003_b0055","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1001\/jama.2015.13766","article-title":"Trends in prescription drug use among adults in the United States from 1999-2012","volume":"314","author":"Kantor","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.bjoms.2025.01.003_b0060","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017739","article-title":"Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden","volume":"7","author":"Brusselaers","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.bjoms.2025.01.003_b0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5056\/jnm.2013.19.1.25","article-title":"Pharmacokinetics and pharmacodynamics of the proton pump inhibitors","volume":"19","author":"Shin","year":"2013","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.bjoms.2025.01.003_b0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2165\/11599320-000000000-00000","article-title":"Prescribing proton pump inhibitors: is it time to pause and rethink?","volume":"72","author":"Vakil","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.bjoms.2025.01.003_b0075","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.11607\/jomi.5662","article-title":"Intake of proton pump inhibitors is associated with an increased risk of dental implant failure","volume":"32","author":"Chrcanovic","year":"2017","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2025.01.003_b0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5125\/jkaoms.2019.45.3.135","article-title":"Proton pump inhibitor intake negatively affects the osseointegration of dental implants: a retrospective study","volume":"45","author":"Altay","year":"2019","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"10.1016\/j.bjoms.2025.01.003_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.oooo.2021.05.002","article-title":"Are proton pump inhibitors associated with implant failure and peri-implantitis?","volume":"133","author":"Rogoszinski","year":"2022","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjoms.2025.01.003_b0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/clr.13684","article-title":"Prevalence and risk\/protective indicators of peri-implant diseases: a university-representative cross-sectional study","volume":"32","author":"Romandini","year":"2021","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0095","doi-asserted-by":"crossref","first-page":"108","DOI":"10.47391\/JPMA.9537","article-title":"Analysis of impact of consumption of proton pump inhibitor on osseointegration of dental implants to the alveolar bone: a systematic critical appraisal","volume":"74","author":"Lal","year":"2024","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.bjoms.2025.01.003_b0100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jobcr.2022.08.016","article-title":"Do proton pump inhibitors affect the biomechanical efficiency of implant?- a systematic review","volume":"12","author":"Verma","year":"2022","journal-title":"J Oral Biol Craniofac Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/prd.12532","article-title":"Emerging factors affecting peri-implant bone metabolism","volume":"94","author":"Insua","year":"2024","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.bjoms.2025.01.003_b0110","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/cre2.616","article-title":"The influence of proton pump inhibitors on tissue attachment around teeth and dental implants: a scoping review","volume":"8","author":"Chawla","year":"2022","journal-title":"Clin Exp Dent Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3390\/dj11060146","article-title":"Do systemic diseases and medications influence dental implant osseointegration and dental implant health? An umbrella review","volume":"11","author":"D'Ambrosio","year":"2023","journal-title":"Dent J (Basel)"},{"key":"10.1016\/j.bjoms.2025.01.003_b0120","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/jips.jips_283_19","article-title":"Effect of proton pump inhibitors on dental implants: a systematic review and meta-analysis","volume":"20","author":"Vinnakota","year":"2020","journal-title":"J Indian Prosthodont Soc"},{"key":"10.1016\/j.bjoms.2025.01.003_b0125","doi-asserted-by":"crossref","first-page":"897","DOI":"10.11607\/jomi.10199","article-title":"Correlates of early dental implant failure: a retrospective study","volume":"38","author":"Basson","year":"2023","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2025.01.003_b0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/medicina59020402","article-title":"The effect of proton pump inhibitors on early implant failure: a retrospective cohort study","volume":"59","author":"Masri","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.bjoms.2025.01.003_b0135","doi-asserted-by":"crossref","first-page":"130","DOI":"10.11607\/jomi.7800","article-title":"Effect of proton pump inhibitors on bone loss at dental implants","volume":"35","author":"Ursomanno","year":"2020","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjoms.2025.01.003_b0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/cid.12455","article-title":"Proton pump inhibitors and the risk of osseointegrated dental implant failure: a cohort study","volume":"19","author":"Wu","year":"2017","journal-title":"Clin Implant Dent Relat Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/1735-3327.318938","article-title":"Effect of systemic administration of omeprazole on osseointegration around titanium dental implants: a histomorphometric study in dogs","volume":"18","author":"Kanounisabet","year":"2021","journal-title":"Dent Res J (Isfahan)"},{"key":"10.1016\/j.bjoms.2025.01.003_b0150","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/clr.13964","article-title":"The effect of the use of proton pump inhibitors, serotonin uptake inhibitors, antihypertensive, and anti-inflammatory drugs on clinical outcomes of functional dental implants: a retrospective study","volume":"33","author":"Corbella","year":"2022","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjoms.2025.01.003_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jormas.2023.101555","article-title":"Retrospective analysis of 50,333 implants on implant failure and associated patient-related factors","volume":"124","author":"Chatzopoulos","year":"2023","journal-title":"J Stomatol Oral Maxillofac Surg"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435625000026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435625000026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T17:07:37Z","timestamp":1747847257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435625000026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0266435625000026"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2025.01.003","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is there any relation between proton pump inhibitors and risk of dental implant failure? A large-scale retrospective study using the BigMouth repository","name":"articletitle","label":"Article Title"},{"value":"British Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjoms.2025.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}