{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:57:00Z","timestamp":1791233820171,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bjoms.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bjoms.2026.05.004","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:36:55Z","timestamp":1781278615000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Next-generation sequencing in head and neck sarcoma: a single-centre institutional experience and review of the literature"],"prefix":"10.1016","volume":"64","author":[{"given":"Yasmin","family":"Ghantous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-1591","authenticated-orcid":false,"given":"Deepti","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3532-3816","authenticated-orcid":false,"given":"Golnaz","family":"Sadeghian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kalavrezos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjoms.2026.05.004_b0005","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jcms.2024.01.005","article-title":"Management of head and neck sarcomas in adults: a retrospective study","volume":"52","author":"Bini","year":"2024","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjoms.2026.05.004_b0010","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3390\/life12111694","article-title":"Surgical margins in soft tissue sarcoma management and corresponding local and systemic recurrence rates: a retrospective study covering 11 years and 169 patients in a single institution","volume":"12","author":"Wittenberg","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.bjoms.2026.05.004_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.526360","article-title":"Radiation-induced sarcoma of the head and neck following radiotherapy for nasopharyngeal carcinoma: a single institutional experience and literature review","volume":"10","author":"Lou","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10151-018-1784-3","article-title":"Salvage TME following TEM: a possible indication for TaTME","volume":"22","author":"Letarte","year":"2018","journal-title":"Tech Coloproctol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0025","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-019-0825-3","article-title":"Expression of concern to: identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K\/mTOR inhibition","volume":"12","author":"Fourneaux","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-030-11096-3_7","article-title":"Sarcoma stem cell heterogeneity","volume":"1123","author":"Hatina","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/jhg.2013.114","article-title":"The promise of whole-exome sequencing in medical genetics","volume":"59","author":"Rabbani","year":"2014","journal-title":"J Hum Genet"},{"key":"10.1016\/j.bjoms.2026.05.004_b0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ng.788","article-title":"Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia","volume":"43","author":"Yan","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.bjoms.2026.05.004_b0045","article-title":"Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines","volume":"6","author":"Chang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bjoms.2026.05.004_b0050","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/ng.3678","article-title":"Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq","volume":"48","author":"Reinius","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.bjoms.2026.05.004_b0055","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s12105-017-0808-z","article-title":"Head and neck round cell sarcomas: a comparative clinicopathologic analysis of 2 molecular subsets: Ewing and CIC-rearranged sarcomas","volume":"11","author":"Owosho","year":"2017","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11912-017-0641-2","article-title":"The role of next-generation sequencing in sarcomas: evolution from light microscope to molecular microscope","volume":"19","author":"Groisberg","year":"2017","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.bjoms.2026.05.004_b0065","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1634\/theoncologist.2017-0290","article-title":"Next-generation sequencing for patients with sarcoma: a single center experience","volume":"23","author":"Cote","year":"2018","journal-title":"Oncologist"},{"key":"10.1016\/j.bjoms.2026.05.004_b0070","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025791","article-title":"Next-generation sequencing strategies","volume":"9","author":"Levy","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.bjoms.2026.05.004_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41525-022-00295-z","article-title":"Medical Genome Initiative. Best practices for the interpretation and reporting of clinical whole genome sequencing","volume":"7","author":"Austin-Tse","year":"2022","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.bjoms.2026.05.004_b0080","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41525-020-00154-9","article-title":"Medical Genome Initiative. Best practices for the analytical validation of clinical whole-genome sequencing intended for the diagnosis of germline disease","volume":"5","author":"Marshall","year":"2020","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.bjoms.2026.05.004_b0085","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s13691-024-00703-4","article-title":"Biphenotypic sinonasal sarcoma diagnosed by detection of PAX3-MAML3 fusion gene using integrated whole-genome and transcriptome sequencing","volume":"13","author":"Okada","year":"2024","journal-title":"Int Cancer Conf J"},{"key":"10.1016\/j.bjoms.2026.05.004_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2021.151800","article-title":"Novel fusion sarcomas including targetable NTRK and ALK","volume":"54","author":"Chen","year":"2021","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/CCO.0000000000000741","article-title":"Next-generation sequencing for the management of sarcomas with no known driver mutations","volume":"33","author":"Vyse","year":"2021","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0100","first-page":"997","article-title":"Next-generation sequencing technology: current trends and advancements","volume":"12","author":"Satam","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.bjoms.2026.05.004_b0105","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1001\/jamaoncol.2025.3608","article-title":"Guidelines for next-generation sequencing in sarcoma diagnosis and treatment: a consensus review","volume":"11","author":"Serrano","year":"2025","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.bjoms.2026.05.004_b0110","unstructured":"J\u00e4ger N, Reuss DE, Sill M, et al. Advancing sarcoma diagnostics with expanded DNA methylation-based classification. MedRxiv preprint. 2025. Available from URL: https:\/\/www.medrxiv.org\/content\/10.1101\/2025.06.30.25330543v1.full.pdf (last accessed 28 July 2026)."},{"key":"10.1016\/j.bjoms.2026.05.004_b0115","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/s41416-024-02721-8","article-title":"Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma","volume":"131","author":"Watkins","year":"2024","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bjoms.2026.05.004_b0120","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1158\/1078-0432.CCR-24-0590","article-title":"Personalized ctDNA for monitoring disease status in head and neck squamous cell carcinoma","volume":"30","author":"Hanna","year":"2024","journal-title":"Clin Cancer Res"}],"container-title":["British Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435626001452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0266435626001452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:23:48Z","timestamp":1791231828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0266435626001452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0266435626001452"],"URL":"https:\/\/doi.org\/10.1016\/j.bjoms.2026.05.004","relation":{},"ISSN":["0266-4356"],"issn-type":[{"value":"0266-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next-generation sequencing in head and neck sarcoma: a single-centre institutional experience and review of the literature","name":"articletitle","label":"Article Title"},{"value":"British Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjoms.2026.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}