{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:06Z","timestamp":1788306726571,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T00:00:00Z","timestamp":1436486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.bjorl.2015.07.011","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:37:21Z","timestamp":1437525441000},"page":"514-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Association between maternal smoking, gender, and cleft lip and palate"],"prefix":"10.1016","volume":"81","author":[{"given":"Daniella Reis Barbosa","family":"Martelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio S\u00e9rgio Oliveira","family":"Swerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00edse A. Mendes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christina","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herc\u00edlio","family":"Martelli J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2015.07.011_bib0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1597\/10-178","article-title":"Genetics of nonsyndromic orofacial clefts","volume":"49","author":"Rahimov","year":"2012","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0150","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1590\/S1806-83242007000400006","article-title":"Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000\u20132005","volume":"21","author":"Martelli-Junior","year":"2007","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1590\/S1806-83242009000100007","article-title":"Prevalence of orofacial clefts and social factors in Brazil","volume":"23","author":"Rodrigues","year":"2009","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1601-0825.2009.01588.x","article-title":"The impact of orofacial clefts on quality of life and healthcare use and costs","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Dis"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0165","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/ajmg.a.35359","article-title":"Risk of cancer in relatives of children born with isolated cleft lip and palate","volume":"158","author":"Vieira","year":"2012","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0170","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/bdra.23011","article-title":"Region 8q24 is a susceptibility locus for nonsyndromic oral clefting in Brazil","volume":"94","author":"Brito","year":"2012","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0175","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/aje\/kwq226","article-title":"Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway,1996\u20132001","volume":"172","author":"Boyles","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0180","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/bdra.20732","article-title":"Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and\/or palate in the Brazilian population","volume":"88","author":"Bufalino","year":"2010","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0185","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapyin pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S1808-86942010000100018","article-title":"paternal age, birth order and interpregnancy interval evaluation for cleft lip-palate","volume":"76","author":"Martelli","year":"2010","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0195","first-page":"213","article-title":"Tobacco smoking and oral clefts: a meta analysis","volume":"82","author":"Little","year":"2004","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0200","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.ede.0000254430.61294.c0","article-title":"Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts","volume":"18","author":"Honein","year":"2007","journal-title":"Epidemiology"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0205","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/bmj.38106.559120.7C","article-title":"Long term follow up study of survival associated with cleft lip and palate at birth","volume":"328","author":"Christensen","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0210","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0266-4356(96)90242-9","article-title":"The incidence of oral clefts: a review","volume":"34","author":"Derijcke","year":"1996","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0215","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5935\/1808-8694.20120018","article-title":"Non-syndromic cleft lip and palate: relationship between sex and clinical extension","volume":"78","author":"Martelli","year":"2012","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00439-010-0863-y","article-title":"Evidence of gene environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with\/without cleft palate","volume":"128","author":"Wu","year":"2010","journal-title":"Hum Genet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0225","first-page":"5","article-title":"Classification of cleft lip and cleft palate. Suggested changes","volume":"27","author":"Spina","year":"1972","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0230","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/ajmg.1320470620","article-title":"Cleft lip (+\/\u2212 cleft palate) in Danish twins, 1970\u20131990","volume":"47","author":"Christensen","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/510518","article-title":"Orofacial cleft risk is increased with maternal smoking and specific detoxification gene variants","volume":"80","author":"Shi","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/bdrc.20117","article-title":"Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects","volume":"84","author":"Shi","year":"2008","journal-title":"Birth Defects Res C: Embryo Today"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0245","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00001648-200109000-00007","article-title":"Smoking, genetics polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction","volume":"12","author":"Van Rooij","year":"2001","journal-title":"Epidemiology"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0250","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1399-0004.2009.01174.x","article-title":"Importance of gene-environment interactions in the etiology of selected birth defects","volume":"75","author":"Zhu","year":"2009","journal-title":"Clin Genet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0255","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1590\/S1806-83242004000200007","article-title":"Current data on the characterization of oral clefts in Brazil","volume":"18","author":"Freitas","year":"2004","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0260","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4317\/medoral.15.e898","article-title":"Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population","volume":"15","author":"Martelli","year":"2010","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0265","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(72)92217-9","article-title":"Sex ratio and cleft lip with or without cleft palate","volume":"2","author":"Niswander","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.bjorl.2015.07.011_bib0270","doi-asserted-by":"crossref","first-page":"e58690","DOI":"10.1371\/journal.pone.0058690","article-title":"Population-based study of birth prevalence and factors associated with cleft lip and\/or palate in Taiwan 2002\u20132009","volume":"8","author":"Lei","year":"2013","journal-title":"PLOS ONE"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869415001020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869415001020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:21:53Z","timestamp":1761722513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869415001020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1808869415001020"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2015.07.011","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between maternal smoking, gender, and cleft lip and palate","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2015.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}