{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:08:30Z","timestamp":1770689310046,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bjorl.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T14:21:17Z","timestamp":1462026077000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus of the rat"],"prefix":"10.1016","volume":"83","author":[{"given":"Paula","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Eslaine Costa Mendes","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Maur\u00edcio","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2016.02.011_bib0175","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1111\/j.1365-2702.2009.02909.x","article-title":"More than ringing in the ears: a review of tinnitus and its psychosocial impact","volume":"18","author":"Holmes","year":"2009","journal-title":"J Clin Nurs"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0180","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsys.2012.00028","article-title":"Salicylate toxicity model of tinnitus","volume":"6","author":"Stolzberg","year":"2012","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0185","doi-asserted-by":"crossref","first-page":"e14260","DOI":"10.1371\/journal.pone.0014260","article-title":"Evidence of key tinnitus-related brain regions documented by a unique combination of manganese-enhanced MRI and acoustic startle reflex testing","volume":"5","author":"Holt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0190","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroimage.2008.09.024","article-title":"Metabolic imaging of rat brain during pharmacologically-induced tinnitus","volume":"44","author":"Paul","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0195","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00221-003-1614-2","article-title":"Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus","volume":"3153","author":"Wallh\u00e4usser-Franke","year":"2003","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0200","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00001756-199702100-00029","article-title":"Salicylate evokes c-fos expression in the brain stem: implications for tinnitus","volume":"8","author":"Wallhausser-Franke","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.heares.2004.03.005","article-title":"Evidence for tinnitus-related plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry","volume":"195","author":"Mahlke","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0378-5955(02)00747-5","article-title":"Differential changes in fos-immunoreactivity at the auditory brainstem after chronic injections of salicylate in rats","volume":"176","author":"Wu","year":"2003","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0215","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1523\/JNEUROSCI.4737-03.2004","article-title":"Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse","volume":"24","author":"Barth","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0220","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1460-9568.1992.tb00190.x","article-title":"Tonotopic order in the adult and developing auditory system of the rat as shown by c-fos immunocytochemistry","volume":"4","author":"Friauf","year":"1992","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0896-6273(92)90105-M","article-title":"fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system","volume":"8","author":"Smeyne","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0230","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2004.10.024","article-title":"Electrical stimulation of the cochlear nerve in rats: analysis of c-fos expression in auditory brainstem nuclei","volume":"1031","author":"Nakamura","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0235","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1101\/lm.1980211","article-title":"Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala","volume":"18","author":"Maddox","year":"2011","journal-title":"Learn. Mem"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1196\/annals.1298.021","article-title":"Song-induced gene expression: a window on song auditory processing and perception","volume":"1016","author":"Mello","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0245","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0378-5955(94)00174-O","article-title":"Salicylate-induced abnormal activity in the inferior colliculus of rats","volume":"82","author":"Chen","year":"1995","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0250","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1121\/1.394391","article-title":"Salicylate-induced changes in spontaneous activity of single units in the inferior colliculus of the guinea pig","volume":"80","author":"Jastreboff","year":"1986","journal-title":"J Acoust Soc Am"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0255","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2003.10.038","article-title":"Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure","volume":"355","author":"Kaltenbach","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0260","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002","article-title":"Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus","volume":"22","author":"Brozoski","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0265","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.heares.2008.02.005","article-title":"Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex","volume":"240","author":"Basta","year":"2008","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0270","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.heares.2010.03.088","article-title":"Effects of sodium salicylate on spontaneous and evoked spike rate in the dorsal cochlear nucleus","volume":"267","author":"Wei","year":"2010","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0275","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neures.2004.07.003","article-title":"Effects of salicylate on spontaneous activity in inferior colliculus brain slices","volume":"50","author":"Basta","year":"2004","journal-title":"Neurosci Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0280","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/j.1476-5381.2009.00321.x","article-title":"Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors containing alpha1-subunits","volume":"157","author":"Lu","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0285","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/00001756-200505310-00007","article-title":"Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons","volume":"16","author":"Xu","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0290","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1523\/JNEUROSCI.5335-07.2008","article-title":"Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses","volume":"28","author":"Ruel","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0295","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1152\/jn.00660.2011","article-title":"Diverse levels of an inwardly rectifying potassium conductance generate heterogeneous neuronal behavior in a population of dorsal cochlear nucleus pyramidal neurons","volume":"107","author":"Leao","year":"2012","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0300","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/exnr.2002.7895","article-title":"Transcription factor modulation and expression in the rat auditory brainstem following electrical intracochlear stimulation","volume":"175","author":"Illing","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0305","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2007.06.016","article-title":"Immediate early gene expression invoked by electrical intracochlear stimulation in some but not all types of neurons in the rat auditory brainstem","volume":"208","author":"Reisch","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0310","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.4081\/ejh.2014.2294","article-title":"Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat","volume":"58","author":"Hu","year":"2014","journal-title":"Eur J Histochem"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0315","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0079-6123(07)66004-X","article-title":"Tinnitus and pain","volume":"166","author":"Moller","year":"2007","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0320","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0378-5955(87)90054-2","article-title":"The analogy between tinnitus and pain: a suggestion for a physiological basis for chronic tinnitus","volume":"28","author":"Tondorff","year":"1987","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0325","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.heares.2005.02.013","article-title":"Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus","volume":"206","author":"Kaltenbach","year":"2005","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0330","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0335","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cne.903330208","article-title":"Differential time course and spatial expression of fos. Jun, and Krox-24 proteins in spinal cord of rats undergoing subacute or chronic somatic inflammation","volume":"333","author":"Lant\u00e9ri-Minet","year":"1993","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bjorl.2016.02.011_bib0340","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.neuroscience.2007.05.019","article-title":"Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: a c-fos study in acute and chronic articular inflammation","volume":"147","author":"Pinto","year":"2007","journal-title":"Neuroscience"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869416300477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869416300477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:32:48Z","timestamp":1761723168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869416300477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1808869416300477"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2016.02.011","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus of the rat","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}