{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:49:54Z","timestamp":1785797394056,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bjorl.2017.05.008","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:30:11Z","timestamp":1498325411000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Osteonecrosis of the jaws: a review and update in etiology and treatment"],"prefix":"10.1016","volume":"84","author":[{"given":"Guilherme H.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuely S.","family":"Chrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamile L.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe I.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane J.","family":"Grando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2017.05.008_bib0255","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis: a new concept of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0260","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw \u2013 2014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00774-016-0810-7","article-title":"Antiresorptive agent-related osteonecrosis of the jaws: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw","volume":"35","author":"Yoneda","year":"2017","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0270","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.coms.2014.02.002","article-title":"Pharmacologic modalities in the treatment of osteoradionecrosis of the jaw","volume":"26","author":"McCaul","year":"2014","journal-title":"Oral Maxillofac Surg Clin N Am"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0275","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.bjoms.2008.04.006","article-title":"Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment","volume":"46","author":"Lyons","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0280","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/joms.2000.9562","article-title":"Osteoradionecrosis of the jaws: clinical characteristics and relation to the field of irradiation","volume":"58","author":"Thorn","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0285","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijom.2010.10.005","article-title":"Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review","volume":"40","author":"Nabil","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0290","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/bonekey.2013.1","article-title":"Mechanisms of action of bisphosphonates in oncology: a scientific concept evolving from antiresorptive to anticancer activities","volume":"2","author":"Clezardin","year":"2013","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0295","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.joms.2007.12.040","article-title":"Oral bisphosphonates and dental implants: a retrospective study","volume":"66","author":"Bell","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0300","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.coms.2014.01.009","article-title":"The role of bisphosphonates in medical oncology and their association with jaw bone necrosis","volume":"26","author":"Eid","year":"2014","journal-title":"Oral Maxillofac Surg Clin N Am"},{"issue":"Suppl. 2","key":"10.1016\/j.bjorl.2017.05.008_bib0305","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1542\/peds.2006-2023H","article-title":"Bisphosphonates: mode of action and pharmacology","volume":"119","author":"Russell","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0310","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.14219\/jada.archive.2005.0108","article-title":"Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper","volume":"136","author":"Migliorati","year":"2005","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0315","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1056\/NEJMc062792","article-title":"Prolonged bisphosphonate release after treatment in children","volume":"356","author":"Papapoulos","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0320","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1517\/13543780903048929","article-title":"RANKL inhibition for the management of patients with benign metabolic bone disorders","volume":"18","author":"Anastasilakis","year":"2009","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0325","first-page":"1793","article-title":"Denosumab and anti-angiogenetic drug-related osteonecrosis of the jaw: an uncommon but potentially severe disease","volume":"33","author":"Sivolella","year":"2013","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0330","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.oooo.2013.02.001","article-title":"Osteonecrosis of the mandible associated with bevacizumab therapy","volume":"115","author":"Santos-Silva","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0335","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1200\/JCO.2008.16.9300","article-title":"Natural history of osteonecrosis of the jaw in patients with multiple myeloma","volume":"26","author":"Badros","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0340","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.joms.2010.02.037","article-title":"Oral bisphosphonate-associated osteonecrosis of the jaw after implant surgery: a case report and literature review","volume":"68","author":"Bedogni","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"issue":"Suppl. 4","key":"10.1016\/j.bjorl.2017.05.008_bib0345","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0501.2009.01772.x","article-title":"What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review","volume":"20","author":"Madrid","year":"2009","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0350","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/jopr.12028","article-title":"Updated clinical considerations for dental implant therapy in irradiated head and neck cancer patients","volume":"22","author":"Tanaka","year":"2013","journal-title":"J Prosthodont"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0355","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.joms.2008.12.004","article-title":"Intravenous bisphosphonate therapy and bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Dodson","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0360","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.otohns.2009.03.013","article-title":"Analysis of outcomes of vascularized flap reconstruction in patients with advanced mandibular osteoradionecrosis","volume":"141","author":"Alam","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0365","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ijom.2007.05.007","article-title":"The influence of hyperbaric oxygen on the outcome of patients treated for osteoradionecrosis: 8 year study","volume":"36","author":"D'Souza","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0370","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/hed.10171","article-title":"Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy","volume":"25","author":"Notani","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0375","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bjoms.2009.06.128","article-title":"Management of patients at risk of osteoradionecrosis: results of survey of dentists and oral & maxillofacial surgery units in the United Kingdom, and suggestions for best practice","volume":"48","author":"McLeod","year":"2010","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0380","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/hed.20121","article-title":"Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial","volume":"27","author":"Delanian","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0385","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ijrobp.2008.12.052","article-title":"Risk factors and dose\u2013effect relationship for mandibular osteoradionecrosis in oral and oropharyngeal cancer patients","volume":"75","author":"Lee","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0390","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.joms.2009.02.008","article-title":"Osteoradionecrosis of the mandible: treatment outcomes and factors influencing the progress of osteoradionecrosis","volume":"67","author":"Oh","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0395","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ijrobp.2010.03.029","article-title":"Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial","volume":"80","author":"Delanian","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0400","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1002\/cncr.26637","article-title":"Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury","volume":"118","author":"Hampson","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0405","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00432-012-1337-5","article-title":"Surgical outcome and prognostic factors after treatment of osteoradionecrosis of the jaws","volume":"139","author":"Mucke","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0410","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.oraloncology.2011.11.013","article-title":"Influence of irradiation and oncologic surgery on head and neck microsurgical reconstructions","volume":"48","author":"Mucke","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0415","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bjoms.2014.02.017","article-title":"Osteoradionecrosis \u2013 a review of current concepts in defining the extent of the disease and a new classification proposal","volume":"52","author":"Lyons","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0420","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/SCS.0000000000002136","article-title":"Osteoradionecrosis of the posterior maxilla: a new approach combining erbium: yttrium aluminium garnet laser and Bichat bulla flap","volume":"26","author":"Porcaro","year":"2015","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0425","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.oooo.2015.10.006","article-title":"Patient and treatment-related risk factors for osteoradionecrosis of the jaw in patients with head and neck cancer","volume":"121","author":"Raguse","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0430","first-page":"145","article-title":"Osteonecrosis of the jaw after oral bisphosphonate for osteoporosis","volume":"16","author":"Tong","year":"2010","journal-title":"Hong Kong Med J"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0435","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijom.2007.09.176","article-title":"Treatment rationale for pathological fractures of the mandible: a series of 44 fractures","volume":"37","author":"Coletti","year":"2008","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0440","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.joms.2011.02.078","article-title":"Bisphosphonate-related osteonecrosis of the jaws \u2013 an initial case series report of treatment combining partial bone resection and autologous platelet-rich plasma","volume":"69","author":"Curi","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0445","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.oraloncology.2011.01.002","article-title":"Efficacy and safety of medical ozone (O3) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: preliminary results of a phase I\u2013II study","volume":"47","author":"Ripamonti","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0450","first-page":"1741","article-title":"Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy","volume":"16","author":"Agrillo","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0455","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.joms.2012.04.001","article-title":"What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics","volume":"70","author":"Freiberger","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0460","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.oraloncology.2011.08.010","article-title":"Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study","volume":"48","author":"Martins","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0465","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.oraloncology.2011.11.004","article-title":"The saxon bisphosphonate register \u2013 therapy and prevention of bisphosphonate-related osteonecrosis of the jaws","volume":"48","author":"Schubert","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0470","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1155\/2014\/427273","article-title":"Conservative treatment of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients","volume":"2014","author":"Melea","year":"2014","journal-title":"Int J Dent"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0475","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1155\/2014\/107690","article-title":"Conservative surgical management of stage I bisphosphonate-related osteonecrosis of the jaw","volume":"2014","author":"Vescovi","year":"2014","journal-title":"Int J Dent"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0480","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00784-014-1384-1","article-title":"Stage-related treatment concept of medication-related osteonecrosis of the jaw \u2013 a case series","volume":"19","author":"Rugani","year":"2015","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcms.2016.08.001","article-title":"Evaluation of surgical outcome and influencing risk factors in patients with medication-related osteonecrosis of the jaws","author":"Klingelhoffer","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0490","series-title":"Antiresorptive drug-related osteonecrosis of the jaw (ARONJ) \u2013 a guide to research","author":"Fleisher","year":"2017"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0495","first-page":"6267406","article-title":"Medication-related osteonecrosis of jaws: a low-level laser therapy and antimicrobial photodynamic therapy case approach","volume":"2016","author":"Minamisako","year":"2016","journal-title":"Case Rep Dent"},{"key":"10.1016\/j.bjorl.2017.05.008_bib0500","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.joms.2009.04.051","article-title":"Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients","volume":"67","author":"Thumbigere-Math","year":"2009","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869417300976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869417300976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:33:31Z","timestamp":1761723211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869417300976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1808869417300976"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2017.05.008","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteonecrosis of the jaws: a review and update in etiology and treatment","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2017.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}