{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:53:56Z","timestamp":1770630836510,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:00:00Z","timestamp":1532736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.bjorl.2018.07.005","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T21:11:25Z","timestamp":1533589885000},"page":"760-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-9573","authenticated-orcid":false,"given":"Taku","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Asamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2018.07.005_bib0130","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","author":"Fokkens","year":"2012","journal-title":"Rhinol Suppl"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0135","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13223-015-0100-2","article-title":"T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients","volume":"11","author":"Baba","year":"2015","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/MOO.0b013e3282fb2885","article-title":"The role of cytokines in chronic rhinosinusitis with nasal polyps","volume":"16","author":"Otto","year":"2008","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0150","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2011.07.049","article-title":"Pathogenesis of chronic rhinosinusitis: inflammation","volume":"128","author":"Van Crombruggen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0155","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.jaci.2015.05.024","article-title":"Increased expression of the epithelial anion transporter pendrin\/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis","volume":"136","author":"Seshadri","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0160","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.4049\/jimmunol.178.8.5144","article-title":"Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels","volume":"178","author":"Pedemonte","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0165","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/clpt.2011.128","article-title":"STAT6 links IL-4\/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease","volume":"90","author":"Nofziger","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000335115","article-title":"Pendrin function in airway epithelia","volume":"28","author":"Nofziger","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0175","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2332\/allergolint.11-OA-0370","article-title":"Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis","volume":"61","author":"Ishida","year":"2012","journal-title":"Allergol Int"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0180","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"117","author":"Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0185","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0190","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1159\/000335119","article-title":"SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct","volume":"28","author":"Ito","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0195","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.4049\/jimmunol.180.9.6262","article-title":"Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease","volume":"180","author":"Nakao","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0200","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12480","article-title":"Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia","volume":"3","author":"Lee","year":"2015","journal-title":"Physiol Rep"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0205","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.4049\/jimmunol.181.3.2203","article-title":"The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model","volume":"181","author":"Nakagami","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0210","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jmg.2008.063610","article-title":"Do mutations of the Pendred syndrome gene, SLC26A4, confer resistance to asthma and hypertension?","volume":"46","author":"Madeo","year":"2009","journal-title":"J Med Genet"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0215","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1128\/IAI.02222-14","article-title":"Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection","volume":"82","author":"Scanlon","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0220","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jaci.2010.05.014","article-title":"Regulation and characterization of IL-17A expression in patients with chronic rhinosinusitis and its relationship with eosinophilic inflammation","volume":"126","author":"Makihara","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0225","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.2500\/ar.2012.3.0030","article-title":"Relationships between IL-17A and macrophages or MUC5AC in eosinophilic chronic rhinosinusitis and proposed pathological significance","volume":"3","author":"Ono","year":"2012","journal-title":"Allergy Rhinol"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0230","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1172\/JCI59353","article-title":"Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition","volume":"121","author":"Choi","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0235","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nbd.2014.02.002","article-title":"Slc26a4-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction","volume":"66C","author":"Ito","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0240","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1159\/000335103","article-title":"Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells","volume":"28","author":"Bizhanova","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0245","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.071516798","article-title":"Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion","volume":"98","author":"Royaux","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bjorl.2018.07.005_bib0250","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000335100","article-title":"Transcriptional regulation of the pendrin gene","volume":"28","author":"Rozenfeld","year":"2011","journal-title":"Cell Physiol Biochem"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869418304993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869418304993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:35:31Z","timestamp":1761723331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869418304993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1808869418304993"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2018.07.005","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2018.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}