{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:45:38Z","timestamp":1793105138427,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["S2011010003947"],"award-info":[{"award-number":["S2011010003947"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bjorl.2018.09.007","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T11:41:21Z","timestamp":1540381281000},"page":"63-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels"],"prefix":"10.1016","volume":"86","author":[{"given":"Congxiang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-3523","authenticated-orcid":false,"given":"Zhong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2018.09.007_bib0180","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07204","article-title":"The development of allergic inflammation","volume":"454","author":"Galli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0185","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2332\/allergolint.47.225","article-title":"Time-course changes in nasal airway resistance after house dust antigen challenge: with special reference to late phase response","volume":"47","author":"Okubo","year":"1998","journal-title":"Allergol Int"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0195","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4049\/jimmunol.182.2.1119","article-title":"Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells","volume":"182","author":"Barrett","year":"2009","journal-title":"J Immunol"},{"issue":"Suppl 86","key":"10.1016\/j.bjorl.2018.09.007_bib0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0205","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1017\/S002221511400036X","article-title":"Quality of life assessment in patients with moderate to severe allergic rhinitis treated with montelukast and\/or intranasal steroids: a randomised, double-blind, placebo-controlled study","volume":"128","author":"Goh","year":"2014","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0210","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5606\/kbbihtisas.2014.48108","article-title":"Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination","volume":"24","author":"Erdogan","year":"2014","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0215","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.anai.2010.05.017","article-title":"Effect of the addition of montelukast to fluticasone propionate for the treatment of perennial allergic rhinitis","volume":"105","author":"Esteitie","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0220","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12070-012-0486-9","article-title":"The effect of combined medical treatment on quality of life in persistent allergic rhinitis","volume":"65","author":"Tatar","year":"2013","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0225","first-page":"659","article-title":"[Meta-analysis of leukotriene receptor antagonist montelukast in the treatment of allergic rhinitis]","volume":"49","author":"Lu","year":"2014","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0230","first-page":"166","article-title":"Diagnostic and treatment principle for allergic rhinitis and a recommended scheme","volume":"40","year":"2005","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0235","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1398-9995.2005.00602.x","article-title":"Seasonal and perennial allergic rhinitis: is this classification adherent to real life?","volume":"60","author":"Ciprandi","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0240","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jaci.2012.07.053","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs","volume":"130","author":"Bousquet","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0245","first-page":"977","article-title":"Guidelines for diagnosis and treatment of allergic rhinitis (2009, Wuyishan)","volume":"44","year":"2009","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0250","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2332\/allergolint.14-RAI-0768","article-title":"Japanese Guideline for Allergic Rhinitis 2014","volume":"63","author":"Okubo","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0255","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2012.08.016","article-title":"Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis","volume":"131","author":"Vadas","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.forsciint.2011.05.020","article-title":"Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis","volume":"212","author":"Mayer","year":"2011","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0265","first-page":"537","article-title":"The role of leukotriene D4 in allergic rhinitis","volume":"60","author":"Okuda","year":"1988","journal-title":"Ann Allergy"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0270","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaci.2005.03.014","article-title":"Expression of functional cysteinyl leukotriene receptors by human basophils","volume":"116","author":"Gauvreau","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0275","doi-asserted-by":"crossref","first-page":"384780","DOI":"10.1155\/2015\/384780","article-title":"Enhanced cysteinyl-leukotriene type 1 receptor expression in T cells from house dust mite-allergic individuals following stimulation with Der p","volume":"2015","author":"Thivierge","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0280","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0194-5998(03)00601-6","article-title":"The role of leukotrienes in nasal allergy","volume":"129","author":"Haberal","year":"2003","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0285","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11882-013-0341-4","article-title":"Role of leukotriene antagonists and antihistamines in the treatment of allergic rhinitis","volume":"13","author":"Cobanoglu","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0290","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1081-1206(10)61339-7","article-title":"The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials","volume":"96","author":"Rodrigo","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0295","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2500\/aap.2008.29.3097","article-title":"The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolence","volume":"29","author":"Santos","year":"2008","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0300","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/194589240501900611","article-title":"Montelukast effectively treats the nighttime impact of seasonal allergic rhinitis","volume":"19","author":"Meltzer","year":"2005","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.anl.2007.06.004","article-title":"Efficacy of nasal corticosteroids alone or combined with antihistamines or montelukast in treatment of allergic rhinitis","volume":"35","author":"Pinar","year":"2008","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0310","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1067\/mai.2002.124467","article-title":"Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis","volume":"109","author":"Pullerits","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0315","first-page":"S1","article-title":"Clinical practice guideline: allergic rhinitis","volume":"152","author":"Seidman","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0320","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1034\/j.1398-9995.56.s66.2.x","article-title":"Pathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma","volume":"56","author":"Bisgaard","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0325","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuropharm.2015.11.005","article-title":"Cherry-picked ligands at histamine receptor subtypes","volume":"106","author":"Sadek","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0330","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1067\/mai.2003.1585","article-title":"Histamine in the immune regulation of allergic inflammation","volume":"112","author":"Akdis","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2003.12.012","article-title":"Molecular and functional aspects of human cysteinyl leukotriene receptors","volume":"50","author":"Capra","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0340","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1378\/chest.119.5.1533","article-title":"The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma","volume":"119","author":"Salvi","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0345","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1056\/NEJM199901213400306","article-title":"Treatment of asthma with drugs modifying the leukotriene pathway","volume":"340","author":"Drazen","year":"1999","journal-title":"New Engl J Med"},{"key":"10.1016\/j.bjorl.2018.09.007_bib0350","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1046\/j.1365-2222.2003.01786.x","article-title":"Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis","volume":"33","author":"Figueroa","year":"2003","journal-title":"Clin Exp Allergy"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180886941830764X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S180886941830764X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:34:32Z","timestamp":1761723272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S180886941830764X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S180886941830764X"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2018.09.007","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2018.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}