{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:08:24Z","timestamp":1781572104600,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["002106-2551\/13-5"],"award-info":[{"award-number":["002106-2551\/13-5"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["16\/2551-0000196-6"],"award-info":[{"award-number":["16\/2551-0000196-6"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["ARD\/PPP\/FAPERGS\/CNPq-08\/2014"],"award-info":[{"award-number":["ARD\/PPP\/FAPERGS\/CNPq-08\/2014"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bjorl.2019.04.012","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T16:11:10Z","timestamp":1560010270000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-8613","authenticated-orcid":false,"given":"Marcos","family":"Soares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analu B. dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tainara M.","family":"Weich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-3154","authenticated-orcid":false,"given":"Gabriela Gomes","family":"M\u00e2nica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-3341","authenticated-orcid":false,"suffix":"Junior","given":"Paulo Ivo","family":"Homem de Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-1511","authenticated-orcid":false,"given":"Mirna Stela","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1242-5423","authenticated-orcid":false,"given":"Thiago Gomes","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2019.04.012_bib0220","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0140-6736(15)60208-2","article-title":"Hearing loss: a global health issue","volume":"385","author":"Looi","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0225","series-title":"Community-based rehabilitation promoting ear and hearing care through CBR","author":"World Health Organization","year":"2012"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0230","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(13)61613-X","article-title":"Auditory and non-auditory effects of noise on health","volume":"383","author":"Basner","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0235","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.heares.2013.06.004","article-title":"Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss","volume":"304","author":"Bao","year":"2013","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0240","first-page":"1","article-title":"Early investigational drugs for hearing loss","volume":"24","author":"Mukherjea","year":"2014","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.heares.2004.03.021","article-title":"Protection of auditory function against noise trauma with local caroverine administration in guinea pigs","volume":"197","author":"Chen","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0255","doi-asserted-by":"crossref","first-page":"10116","DOI":"10.1523\/JNEUROSCI.19-22-10116.1999","article-title":"Heat stress and protection from permanent acoustic injury in mice","volume":"19","author":"Yoshida","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0260","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jnr.20417","article-title":"Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation","volume":"81","author":"Fairfield","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0265","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0378-5955(93)90102-7","article-title":"Detection of HSP 72 synthesis after acoustic overstimulation in rat cochlea","volume":"69","author":"Lim","year":"1993","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0270","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10162-006-0043-x","article-title":"Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death","volume":"7","author":"Cunningham","year":"2006","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10162-014-0491-7","article-title":"Heat shock protein-mediated protection against cisplatin-induced hair cell death","volume":"16","author":"Baker","year":"2014","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0280","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s12192-008-0097-2","article-title":"Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death","volume":"14","author":"Taleb","year":"2009","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0285","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2014.12.060","article-title":"17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro","volume":"588","author":"Liu","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0290","doi-asserted-by":"crossref","first-page":"C1509","DOI":"10.1152\/ajpcell.00240.2009","article-title":"Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity","volume":"297","author":"Hamiel","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0295","doi-asserted-by":"crossref","first-page":"R1839","DOI":"10.1152\/ajpregu.00755.2006","article-title":"Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression","volume":"292","author":"Singleton","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0300","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.lfs.2013.11.009","article-title":"Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: involvement of heat shock protein pathways","volume":"94","author":"Petry \u00c9R","year":"2014","journal-title":"Life Sci"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.heares.2012.07.005","article-title":"Inner hair cells of mice express the glutamine transporter SAT1","volume":"292","author":"Oguchi","year":"2012","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0310","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cbf.1739","article-title":"HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?","volume":"29","author":"Heck","year":"2011","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0315","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.mehy.2010.10.025","article-title":"Extracellular heat shock proteins (eHSP70) in exercise: possible targets outside the immune system and their role for neurodegenerative disorders treatment","volume":"76","author":"Krause","year":"2011","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0320","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/1389203715666140331113057","article-title":"Extracellular Hsp70: export and function","volume":"15","author":"De Maio","year":"2014","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0325","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12192-017-0771-3","article-title":"Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio","volume":"22","author":"Heck","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0330","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11010-016-2791-1","article-title":"Modulation of rat monocyte\/macrophage innate functions by increasing intensities of swimming exercise is associated with heat shock protein status","volume":"421","author":"Sch\u00f6ler","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0335","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s13105-016-0503-7","article-title":"Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis","volume":"72","author":"Goettems-Fiorin","year":"2016","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0340","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1523\/JNEUROSCI.2282-12.2013","article-title":"Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense","volume":"33","author":"Fetoni","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0345","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2015\/249205","article-title":"The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management","volume":"2015","author":"Krause","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0350","first-page":"374","article-title":"Heat shock proteins and heat therapy for type 2 diabetes: pros and cons","volume":"18","author":"Krause","year":"2015","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0355","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jnr.20764","article-title":"Proinflammatory cytokines expression in noise-induced damaged cochlea","volume":"83","author":"Fujioka","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0360","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/00016489.2014.953203","article-title":"Utility of auditory steady-state and brainstem responses in age-related hearing loss in rats","volume":"135","author":"Sanz-Fern\u00e1ndez","year":"2015","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0365","first-page":"295","article-title":"The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease","volume":"17","author":"Newsholme","year":"2014","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0370","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0378-5955(03)00180-1","article-title":"Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure","volume":"182","author":"Sugahara","year":"2003","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0375","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1288\/00005537-199209000-00005","article-title":"Expression of the major mammalian stress protein in the rat cochlea following transient ischemia","volume":"102","author":"Myers","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0380","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/000164800750000793","article-title":"Expression of heat shock protein 72 in rat cochlea with cisplatin-induced acute ototoxicity","volume":"120","author":"Oh","year":"2000","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0385","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-5955(00)00161-1","article-title":"Sound conditioning reduces noise-induced permanent threshold shift in mice","volume":"148","author":"Yoshida","year":"2000","journal-title":"Hear Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10162-011-0289-9","article-title":"Induction of heat shock proteins by hyperthermia and noise overstimulation in Hsf1\u2212\/\u2212 mice","volume":"13","author":"Gong","year":"2012","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0395","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.bbamem.2013.12.015","article-title":"Plasma membranes as heat stress sensors: from lipid-controlled molecular switches to therapeutic applications","volume":"1838","author":"T\u00f6r\u00f6k","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0400","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41110-016-0021-y","article-title":"Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions","volume":"41","author":"Leite","year":"2016","journal-title":"Nutrire"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0405","first-page":"14","article-title":"Glutamine metabolism and its effects on immune response: molecular mechanism and gene expression","volume":"41","author":"de Oliveira","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0410","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.nut.2005.11.002","article-title":"Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise","volume":"22","author":"Rogero","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0415","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.nut.2013.10.019","article-title":"Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia","volume":"30","author":"Cruzat","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0420","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0006-8993(84)90960-0","article-title":"Preferential glutamine uptake by cochlear hair cells: implications for the afferent cochlear transmitter","volume":"290","author":"Ryan","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0425","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/000164800750000568","article-title":"Glutamate is the afferent neurotransmitter in the human cochlea","volume":"120","author":"Nordang","year":"2000","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.04.012_bib0430","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12192-010-0236-4","article-title":"Extracellular heat shock proteins cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damageIt is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa","volume":"16","author":"De Maio","year":"2011","journal-title":"Cell Stress Chaperones"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869419300400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869419300400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:35:33Z","timestamp":1761723333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869419300400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1808869419300400"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2019.04.012","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2019.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}