{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:06:22Z","timestamp":1791950782782,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bjorl.2019.08.007","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T08:37:32Z","timestamp":1570091852000},"page":"178-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-2550","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-3871","authenticated-orcid":false,"given":"Jian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2019.08.007_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0010","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.jaci.2015.10.010","article-title":"Current and future treatment options for adult chronic rhinosinusitis: focus on nasal polyposis","volume":"136","author":"Bachert","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11882-006-0026-3","article-title":"Pathogenesis of chronic rhinosinusitis","volume":"6","author":"Van Cauwenberge","year":"2006","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0025","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00109-010-0590-9","article-title":"Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity","volume":"88","author":"Kamen","year":"2010","journal-title":"J Mol Med"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0030","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ecl.2017.07.010","article-title":"Regulation of immune function by vitamin d and its use in diseases of immunity","volume":"46","author":"Vanherwegen","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/alr.21585","article-title":"Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis","volume":"6","author":"Mostafa","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0040","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/alr.21274","article-title":"Impact of vitamin D deficiency upon clinical presentation in nasal polyposis","volume":"4","author":"Schlosser","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0045","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2008.05.038","article-title":"Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhino -sinusitis","volume":"22","author":"Pinto","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0050","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0060","unstructured":"Wells GASB, O\u2019Connell D, Peterson J, Welch V, Losos MTP. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp 2000."},{"key":"10.1016\/j.bjorl.2019.08.007_bib0065","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions, Version 5.0.2 updated September 2009, The Cochrane Collaboration http:\/\/cochrane.org\/resources\/handbook\/.","DOI":"10.1002\/9780470712184"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2249.2011.04325.x","article-title":"Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis","volume":"164","author":"Mulligan","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0075","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/0194599812448852","article-title":"Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps","volume":"147","author":"Mulligan","year":"2012","journal-title":"Otolaryngl Head Neck Surg"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0080","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jaci.2014.01.039","article-title":"Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis","volume":"134","author":"Mulligan","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0085","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/alr.21704","article-title":"Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps","volume":"6","author":"Carroll","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0090","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.12659\/MSM.898410","article-title":"Is nasal polyposis related to levels of serum vitamin D and vitamin D receptor gene expression?","volume":"22","author":"Erdag","year":"2016","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0095","first-page":"4625","article-title":"Circulatory levels of 25-OHD and vitamin D binding protein in patients with chronic rhinosinusitis with polyposis: A case-control study","volume":"28","author":"Shanaki","year":"2017","journal-title":"Biomed Res"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.amjoto.2018.09.003","article-title":"Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps","volume":"40","author":"Wang","year":"2019","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0110","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1096\/fj.01-0433rev","article-title":"Vitamin D: its role and uses in immunology","volume":"15","author":"Deluca","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0115","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003045","article-title":"Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages","volume":"3","author":"Fabri","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0125","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jsbmb.2015.01.017","article-title":"Vitamin D for the treatment of respiratory diseases: is it the end or just the beginning?","volume":"148","author":"Yawn","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/00129785-200404010-00007","article-title":"Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland","volume":"4","author":"Laufs","year":"2004","journal-title":"Am J Pharmacogenomics"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/alr.21474","article-title":"Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis","volume":"5","author":"Sansoni","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"10.1016\/j.bjorl.2019.08.007_bib0140","article-title":"Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study","volume":"1","author":"Faruk","year":"2014","journal-title":"J Histol Histopathol"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0145","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.2500\/ajra.2013.27.3948","article-title":"Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients","volume":"27","author":"Wang","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.bjorl.2019.08.007_bib0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ajcn\/76.1.187","article-title":"Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994","volume":"76","author":"Nesby-O\u2019Dell","year":"2002","journal-title":"Am J Clin Nutr"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869419301144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869419301144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:36:07Z","timestamp":1761723367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869419301144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1808869419301144"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2019.08.007","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between serum vitamin D and chronic rhinosinusitis: a meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2019.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}