{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:34:30Z","timestamp":1794202470194,"version":"4.8.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.bjorl.2022.10.050","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T22:31:05Z","timestamp":1667082665000},"page":"339-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-8306","authenticated-orcid":false,"given":"Wuyang","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-623X","authenticated-orcid":false,"given":"Wenlong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-1583","authenticated-orcid":false,"given":"Lan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2022.10.050_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"Koufman","year":"1991","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jvoice.2013.12.015","article-title":"Changes in the quality of life of patients with laryngopharyngeal reflux after treatment","volume":"28","author":"Lee","year":"2014","journal-title":"J Voice"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archotol.131.4.315","article-title":"Validation of a quality-of-life instrument for laryngopharyngeal reflux","volume":"131","author":"Carrau","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0020","first-page":"2","article-title":"Laryngopharyngeal reflux 2002: a new paradigm of airway disease","volume":"81","author":"Koufman","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/00005537-200205000-00019","article-title":"Association of laryngopharyngeal symptoms with gastroesophageal reflux disease","volume":"112","author":"Tauber","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0030","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/00005537-200206000-00016","article-title":"The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease","volume":"112","author":"Branski","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5056\/jnm18001","article-title":"Advantages and disadvantages of long-term proton pump inhibitor use","volume":"24","author":"Kinoshita","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00405-009-1176-4","article-title":"Gastroesophageal reflux\/laryngopharyngeal reflux disease: a critical analysis of the literature","volume":"267","author":"Kotby","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0045","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/01.mlg.0000172043.51871.d9","article-title":"Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux","volume":"115","author":"Knight","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0050","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00405-017-4845-8","article-title":"Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis","volume":"275","author":"Wang","year":"2018","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0060","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/0194599820951183","article-title":"Diagnostic utility of salivary pepsin as compared with 24-hour dual pH\/impedance probe in laryngopharyngeal reflux","volume":"164","author":"Zhang","year":"2021","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0070","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/lary.28320","article-title":"Pepsin and oropharyngeal pH monitoring to diagnose patients with laryngopharyngeal reflux","volume":"130","author":"Weitzendorfer","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0075","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/lary.28182","article-title":"Correlation of salivary and nasal lavage pepsin with MII-pH testing","volume":"130","author":"Klimara","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4082\/kjfm.18.0207","article-title":"Usefulness of pep-test for laryngo-pharyngeal reflux: a pilot study in primary care","volume":"41","author":"Bozzani","year":"2020","journal-title":"Korean J Fam Med"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0085","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jvoice.2018.07.008","article-title":"The diagnostic usefullness of the salivary pepsin test in symptomatic laryngopharyngeal reflux","volume":"33","author":"Barona-Lleo","year":"2019","journal-title":"J Voice"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0090","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12936","article-title":"Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance\/pH monitoring in pediatric patients","volume":"29","author":"Fortunato","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0095","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jpeds.2016.06.033","article-title":"Salivary pepsin lacks sensitivity as a diagnostic tool to evaluate extraesophageal reflux disease","volume":"177","author":"Dy","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0100","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cgh.2015.11.017","article-title":"Abilities of oropharyngeal pH tests and salivary pepsin analysis to discriminate between asymptomatic volunteers and subjects with symptoms of laryngeal irritation","volume":"14","author":"Yadlapati","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/gutjnl-2014-307049","article-title":"Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease","volume":"64","author":"Hayat","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/balkanmedj.2015.15824","article-title":"Immunoserologic pepsin detection in the saliva as a non-invasive rapid diagnostic test for laryngopharyngeal reflux","volume":"32","author":"Ocak","year":"2015","journal-title":"Balkan Med J"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0115","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.rmed.2015.05.019","article-title":"Detecting laryngopharyngeal reflux in patients with upper airways symptoms: symptoms, signs or salivary pepsin?","volume":"109","author":"Spyridoulias","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0120","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/MCG.0000000000000011","article-title":"Objective detection of esophagopharyngeal reflux in patients with hoarseness and endoscopic signs of laryngeal inflammation","volume":"48","author":"Hayat","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0125","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/lary.23252","article-title":"Rapid salivary pepsin test: blinded assessment of test performance in gastroesophageal reflux disease","volume":"122","author":"Saritas Yuksel","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000143795","article-title":"Pepsin detection in the sputum\/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms","volume":"77","author":"Kim","year":"2008","journal-title":"Digestion"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0135","first-page":"145","article-title":"Is pepsin detected in the saliva of patients who experience pharyngeal reflux?","volume":"11","author":"Printza","year":"2007","journal-title":"Hippokratia"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0140","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1023\/A:1025467600662","article-title":"Comparison of a salivary\/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung","volume":"48","author":"Potluri","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11894-016-0515-z","article-title":"How to approach laryngopharyngeal reflux: an otolaryngology perspective","volume":"18","author":"Dhillon","year":"2016","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0150","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11605-011-1741-1","article-title":"How much pharyngeal exposure is \u201cnormal\u201d? Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII)","volume":"16","author":"Hoppo","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0155","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/00016480152602357","article-title":"Effect of aggressive therapy on laryngeal symptoms and voice characteristics in patients with gastroesophageal reflux","volume":"121","author":"Hamdan","year":"2001","journal-title":"Acta Oto-Laryngologica"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0160","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/j.1572-0241.2006.00844.x","article-title":"Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials","volume":"101","author":"Qadeer","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1067\/mhn.2002.125760","article-title":"Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery","volume":"127","author":"Koufman","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.otorri.2017.03.001","article-title":"Salivary pepsin test: useful and simple tool for the laryngopharyngeal reflux diagnosis","volume":"69","author":"Barona-Lle\u00f3","year":"2018","journal-title":"Acta Otorrinolaringol Esp (Engl Ed)"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0175","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s10620-004-9585-0","article-title":"Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux?","volume":"49","author":"Poelmans","year":"2004","journal-title":"Dig Dis Sci."},{"key":"10.1016\/j.bjorl.2022.10.050_bib0180","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0030-6665(20)31068-9","article-title":"Functional voice disorders","volume":"24","author":"Koufman","year":"1991","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0185","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0002-9270(00)01074-1","article-title":"ENT manifestations of gastroesophageal reflux","volume":"95","author":"Wong","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0190","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/gut.2009.200063","article-title":"Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study","volume":"59","author":"Dent","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.bjorl.2022.10.050_bib0195","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1002\/lary.26018","article-title":"Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux","volume":"126","author":"Na","year":"2016","journal-title":"Laryngoscope"}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869422001847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869422001847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:38:12Z","timestamp":1761723492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869422001847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1808869422001847"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2022.10.050","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2022.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}