{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:03:31Z","timestamp":1761743011287,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803546"],"award-info":[{"award-number":["81803546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2019JZZY011104","ZR2017MH068","ZR2018LH024"],"award-info":[{"award-number":["2019JZZY011104","ZR2017MH068","ZR2018LH024"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.bjorl.2023.02.001","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T09:36:48Z","timestamp":1676626608000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of Merocel sponge with Lipopolysaccharide to establish rat rhinosinusitis model"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-6244","authenticated-orcid":false,"given":"Mengmeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-1141","authenticated-orcid":false,"given":"Junjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-5195","authenticated-orcid":false,"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-4900","authenticated-orcid":false,"given":"Ming","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-1803","authenticated-orcid":false,"given":"Leiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-1219","authenticated-orcid":false,"given":"Wenyu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2023.02.001_bib0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis 2021","volume":"11","author":"Orlandi","year":"2021","journal-title":"Int Forum Allergy Rhinol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0010","first-page":"5275","article-title":"Establishment of a mouse model of lipopolysaccharide-induced neutrophilic nasal polyps","volume":"14","author":"Wang","year":"2017","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4193\/Rhin20.601","article-title":"Executive summary of EPOS 2020 including integrated care pathways","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"2 Suppl","key":"10.1016\/j.bjorl.2023.02.001_bib0020","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0025","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/lio2.117","article-title":"Models for the study of nasal and sinus physiology in health and disease: a review of the literature","volume":"2","author":"Al-Sayed","year":"2017","journal-title":"Laryngoscope Investig Otolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0030","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11882-011-0180-0","article-title":"Actual concepts in rhinosinusitis: a review of clinical presentations, inflammatory pathways, cytokine profiles, remodeling, and management","volume":"11","author":"Eloy","year":"2011","journal-title":"Curr Allergy Asthma Rep."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1053\/ajot.2000.9874","article-title":"Computed tomography vs. magnetic resonance imaging of acute bacterial sinusitis: a rabbit model","volume":"21","author":"Kerschner","year":"2000","journal-title":"Am J Otolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0040","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1097\/00005537-200012000-00021","article-title":"Effects of beta-toxin of Staphylococcus aureus on ciliary activity of nasal epithelial cells","volume":"110","author":"Kim","year":"2000","journal-title":"Laryngoscope."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0045","first-page":"214","article-title":"Combination of Merocel Sponge with Streptococcus Pneumoniae to establish rat model of acute rhinosinusitis","volume":"6","author":"Ye","year":"2006","journal-title":"Chin J Ophthalmol Otorhinolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/000348940511400511","article-title":"Rat model of platelet-activating factor-induced rhinosinusitis","volume":"114","author":"Jeon","year":"2005","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0022215100134218","article-title":"The use of Merocel nasal packs in the treatment of epistaxis","volume":"110","author":"Pringle","year":"1996","journal-title":"J Laryngol Otol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0060","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00405-011-1483-4","article-title":"Developing a mouse model of acute bacterial rhinosinusitis","volume":"268","author":"Jin","year":"2011","journal-title":"Eur Arch Otorhinolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0065","article-title":"Effects of a tumor necrosis factor-\u03b1 antagonist on experimentally induced rhinosinusitis","volume":"2011","author":"Kim","year":"2011","journal-title":"J Biomed Biotechnol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0070","first-page":"241","article-title":"Endotoxin in the environment--exposure and effects","volume":"8","author":"Rylander","year":"2002","journal-title":"J Endotoxin Res."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0075","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Critical Care Med."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0080","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/cc7733","article-title":"The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data","volume":"13","author":"Melamed","year":"2009","journal-title":"Critical Care (London, England)."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0085","first-page":"121","article-title":"The effect of xinan nasoyuan fangliu extract on the apoptosis of olfactory neurons in rats with acute sinusitis based on SDF-1\/CXCR4 signaling pathway","volume":"31","author":"Zhang","year":"2021","journal-title":"Chin J Comp Med."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0090","first-page":"1","article-title":"Summary health statistics for U.S. adults: national health interview survey, 2012","volume":"260","author":"Blackwell","year":"2014","journal-title":"Vital Health Stat 10"},{"key":"10.1016\/j.bjorl.2023.02.001_bib0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2500\/105065897781446766","article-title":"Gram negative sinusitis: a bacteriologic and histologic study in rabbits","volume":"11","author":"Bolger","year":"1997","journal-title":"Am J Rhinol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0100","article-title":"Quercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats","volume":"71","author":"Tiboc-Schnell","year":"2020","journal-title":"J Physiol Pharmacol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0105","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1038\/s41598-021-85785-3","article-title":"Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis","volume":"11","author":"Liang","year":"2021","journal-title":"Sci Rep."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2045-7022-1-5","article-title":"Allergy as an epithelial barrier disease","volume":"1","author":"Mattila","year":"2011","journal-title":"Clin Transl Allergy."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0115","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2500\/ajr.2008.22.3228","article-title":"Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis","volume":"22","author":"Kern","year":"2008","journal-title":"Am J Rhinol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0120","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.otc.2017.08.002","article-title":"The role of the sinonasal epithelium in allergic rhinitis","volume":"50","author":"London","year":"2017","journal-title":"Otolaryngol Clin North Am."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0125","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.addr.2005.01.009","article-title":"Occludin: structure, function, and regulation","volume":"57","author":"Feldman","year":"2005","journal-title":"Adv Drug Deliv Rev."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.603863","article-title":"Inhibition of inflammation and regulation of AQPs\/ENaCs\/Na(+)-K(+)-ATPase mediated alveolar fluid Transport by total flavonoids extracted from Nervilia fordii in lipopolysaccharide-induced acute lung injury","volume":"12","author":"Yin","year":"2021","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.amjoto.2013.11.011","article-title":"Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps","volume":"35","author":"Shikani","year":"2014","journal-title":"Am J Otolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxicon.2014.05.014","article-title":"Anti-inflammatory effect of Natterins, the major toxins from the Thalassophryne nattereri fish venom is dependent on TLR4\/MyD88\/PI3K signaling pathway","volume":"87","author":"Ferreira","year":"2014","journal-title":"Toxicon."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0145","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.kjms.2013.04.002","article-title":"EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis","volume":"29","author":"Chiu","year":"2013","journal-title":"Kaohsiung J Med Sci."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204709","article-title":"A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis","volume":"13","author":"Alt","year":"2018","journal-title":"PloS One."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/lio2.21","article-title":"Innate immunity, and chronic rhinosinusitis: What we have learned from animal models","volume":"1","author":"London","year":"2016","journal-title":"Laryngoscope Investig Otolaryngol."},{"key":"10.1016\/j.bjorl.2023.02.001_bib0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molimm.2013.11.003","article-title":"Jellyfish collagen stimulates production of TNF-\u03b1 and IL-6 by J774.1 cells through activation of NF-\u03baB and JNK via TLR4 signaling pathway","volume":"58","author":"Putra","year":"2014","journal-title":"Mol Immunol."}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869423000083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869423000083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:38:21Z","timestamp":1761723501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869423000083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1808869423000083"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2023.02.001","relation":{},"ISSN":["1808-8694"],"issn-type":[{"type":"print","value":"1808-8694"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of Merocel sponge with Lipopolysaccharide to establish rat rhinosinusitis model","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2023.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}