{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:05:16Z","timestamp":1785215116146,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bjorl.2024.101520","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T23:45:32Z","timestamp":1730850332000},"page":"101520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors for cervical lymph node metastasis in oropharyngeal cancer and its impact on prognosis"],"prefix":"10.1016","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4327-8246","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-940X","authenticated-orcid":false,"given":"Zhilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5520-7322","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-4034","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-2481","authenticated-orcid":false,"given":"Shuxin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2024.101520_bib0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"key":"10.1016\/j.bjorl.2024.101520_bib0010","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1200\/JCO.22.02625","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"41","author":"Chaturvedi","year":"2023","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J Natl Cancer Inst."},{"key":"10.1016\/j.bjorl.2024.101520_bib0020","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3322\/caac.21389","article-title":"Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual","volume":"67","author":"Lydiatt","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bjorl.2024.101520_bib0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejca.2020.04.027","article-title":"The current epidemic of HPV-associated oropharyngeal cancer: an 18-year Danish population-based study with 2,169 patients","volume":"134","author":"Zamani","year":"2020","journal-title":"Eur J Cancer."},{"key":"10.1016\/j.bjorl.2024.101520_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104637","article-title":"Increasing prevalence of HPV in oropharyngeal carcinoma suggests adaptation of p16 screening in Southeast Asia","volume":"132","author":"Argirion","year":"2020","journal-title":"J Clin Virol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0035","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4132\/jptm.2020.06.22","article-title":"Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas","volume":"54","author":"Kim","year":"2020","journal-title":"J Pathol Transl Med."},{"key":"10.1016\/j.bjorl.2024.101520_bib0040","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3390\/microorganisms8101498","article-title":"Evolving profile of hpv-driven oropharyngeal squamous cell carcinoma in a national cancer institute in italy: a 10-year retrospective study","volume":"8","author":"Don\u00e0","year":"2020","journal-title":"Microorganisms."},{"key":"10.1016\/j.bjorl.2024.101520_bib0045","doi-asserted-by":"crossref","first-page":"13219","DOI":"10.1038\/s41598-020-70118-7","article-title":"Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe","volume":"10","author":"Mena","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.bjorl.2024.101520_bib0050","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/v13071326","article-title":"A contemporary systematic review on repartition of HPV-positivity in oropharyngeal cancer worldwide","volume":"13","author":"Carlander","year":"2021","journal-title":"Viruses."},{"key":"10.1016\/j.bjorl.2024.101520_bib0055","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/cncr.31841","article-title":"The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status","volume":"125","author":"Faraji","year":"2019","journal-title":"Cancer."},{"key":"10.1016\/j.bjorl.2024.101520_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9594568","article-title":"Association of p16 as prognostic factors for oropharyngeal cancer: evaluation of p16 in 1470 patients for a 16-year study in Northeast China","volume":"2018","author":"Meng","year":"2018","journal-title":"Biomed Res Int."},{"key":"10.1016\/j.bjorl.2024.101520_bib0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.oooo.2019.11.008","article-title":"Evaluation of p16 as a surrogate marker for transcriptionally active human papillomavirus status of oropharyngeal squamous cell carcinoma in an eastern Chinese population","volume":"129","author":"Xu","year":"2020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1158\/2326-6066.CIR-22-0454","article-title":"CD161 characterizes an inflamed subset of cytotoxic T lymphocytes associated with prolonged survival in human papillomavirus driven oropharyngeal cancer","volume":"11","author":"Wei","year":"2023","journal-title":"Cancer Immunol Res."},{"key":"10.1016\/j.bjorl.2024.101520_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2023.106490","article-title":"Re-examining predictors of pathologic lymph node positivity in clinically node negative oral cavity cancer","volume":"144","author":"Anderson","year":"2023","journal-title":"Oral Oncol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0080","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1002\/hed.26715","article-title":"Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma","volume":"43","author":"Matija","year":"2021","journal-title":"Head Neck."},{"key":"10.1016\/j.bjorl.2024.101520_bib0085","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cncr.23206","article-title":"Adjuvant radiotherapy improves overall survival for patients with lymph node-positive head and neck squamous cell carcinoma","volume":"112","author":"Lavaf","year":"2008","journal-title":"Cancer."},{"key":"10.1016\/j.bjorl.2024.101520_bib0090","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.radonc.2021.01.028","article-title":"Prevalence and distribution of cervical lymph node metastases in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma","volume":"157","author":"Bauwens","year":"2021","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0095","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.3389\/fonc.2020.01751","article-title":"HPV detection in head and neck squamous cell carcinomas: what is the issue?","volume":"10","author":"Augustin","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0100","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijrobp.2007.09.058","article-title":"Adjuvant radiotherapy and survival for patients with node-positive head and neck cancer: An analysis by primary site and nodal stage","volume":"71","author":"Kao","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.bjorl.2024.101520_bib0105","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1080\/00016489.2019.1669820","article-title":"Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe: a system-artic review","volume":"139","author":"Stjernstr\u00f8m","year":"2019","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0110","first-page":"107","article-title":"Expert consensus on diagnosis and treatment of cervical metastatic squamous cell carcinoma of unknown primary (2024)","volume":"59","year":"2024","journal-title":"Chin J Otorhinolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjorl.2024.101520_bib0115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1600-0714.2009.00797.x","article-title":"The prognostic significance of histological features in oral squamous cell carcinoma","volume":"38","author":"Larsen","year":"2009","journal-title":"J Oral Pathol Med."},{"key":"10.1016\/j.bjorl.2024.101520_bib0120","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1158\/1055-9965.EPI-19-0038","article-title":"Incidence and demographic burden of HPV-associated oropharyngeal head and neck cancers in the United States","volume":"28","author":"Mahal","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"10.1016\/j.bjorl.2024.101520_bib0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/modpathol.2016.152","article-title":"Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can!","volume":"30","author":"Lewis","year":"2017","journal-title":"Mod Pathol."},{"key":"10.1016\/j.bjorl.2024.101520_bib0130","first-page":"974","article-title":"Ki-67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma","volume":"17","author":"Jing","year":"2019","journal-title":"Oncol Lett."},{"issue":"1","key":"10.1016\/j.bjorl.2024.101520_bib0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-024-12539-5","article-title":"Prognostic role of tumor-infiltrating lymphocytes in oral squamous cell carcinoma","volume":"24","author":"Wongpattaraworakul","year":"2024","journal-title":"BMC Cancer."}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869424001356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869424001356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T01:10:52Z","timestamp":1744506652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869424001356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1808869424001356"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2024.101520","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for cervical lymph node metastasis in oropharyngeal cancer and its impact on prognosis","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2024.101520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101520"}}