{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:49:14Z","timestamp":1777016954098,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025ZX165"],"award-info":[{"award-number":["2025ZX165"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bjorl.2026.101772","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:08:02Z","timestamp":1770329282000},"page":"101772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetically predicted plasma metabolites mediate the relation between inflammatory factors and Meniere's disease"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-9121","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2026.101772_bib0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/WCO.0000000000001021","article-title":"M\u00e9ni\u00e8re\u2019s disease: new guidelines, subtypes, imaging, and more","volume":"35","author":"Hoskin","year":"2022","journal-title":"Curr Opin Neurol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/00016489.2024.2447564","article-title":"Can switching stimulus polarity identify Meniere\u2019s disease? A preliminary investigation on ABR","volume":"145","author":"Dutta","year":"2025","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/MOO.0000000000000921","article-title":"M\u00e9ni\u00e8re\u2019s disease is a disorder of the inner ear","volume":"31","author":"Ahmad","year":"2023","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"key":"10.1016\/j.bjorl.2026.101772_bib0020","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1007\/s10238-023-01192-0","article-title":"M\u00e9ni\u00e8re\u2019s disease and allergy: epidemiology, pathogenesis, and therapy","volume":"23","author":"Xu","year":"2023","journal-title":"Clin Exp Med."},{"key":"10.1016\/j.bjorl.2026.101772_bib0025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/coa.13350","article-title":"Different medications for the treatment of M\u00e9ni\u00e8re\u2019s disease by intratympanic injection: a systematic review and network meta-analysis","volume":"44","author":"Cao","year":"2019","journal-title":"Clin Otolaryngol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/proteomes12020017","article-title":"The current state of proteomics and metabolomics for inner ear health and disease","volume":"12","author":"Khorrami","year":"2024","journal-title":"Proteomes."},{"key":"10.1016\/j.bjorl.2026.101772_bib0035","article-title":"The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy","volume":"11","author":"Li","year":"2023","journal-title":"PeerJ."},{"key":"10.1016\/j.bjorl.2026.101772_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.21053\/ceo.2021.00920","article-title":"Cytokines and inflammation in Meniere disease","volume":"15","author":"Frejo","year":"2022","journal-title":"Clin Exp Otorhinolaryngol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12916-023-02761-6","article-title":"Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study","volume":"21","author":"Long","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.bjorl.2026.101772_bib0050","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","article-title":"Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets","volume":"24","author":"Zhao","year":"2023","journal-title":"Nat Immunol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41588-022-01270-1","article-title":"Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases","volume":"55","author":"Chen","year":"2023","journal-title":"Nat Genetics."},{"key":"10.1016\/j.bjorl.2026.101772_bib0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gepi.22506","article-title":"Statistical methods for cis-Mendelian randomization with two-sample summary-level data","volume":"47","author":"Gkatzionis","year":"2023","journal-title":"Genet Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0065","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data","volume":"46","author":"Yavorska","year":"2017","journal-title":"Int J Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0070","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Euro J Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0080","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0085","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00394-020-02369-z","article-title":"Habitual coffee intake and risk for nonalcoholic fatty liver disease: a two-sample Mendelian randomization study","volume":"60","author":"Zhang","year":"2021","journal-title":"Euro J Nutrition."},{"key":"10.1016\/j.bjorl.2026.101772_bib0090","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10654-021-00757-1","article-title":"Mendelian randomisation for mediation analysis: current methods and challenges for implementation","volume":"36","author":"Carter","year":"2021","journal-title":"Euro J Epidemiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0095","article-title":"Genetics and analysis of quantitative traits[M]","author":"Lynch","year":"1998","journal-title":"Sunderland, MA: Sinauer"},{"key":"10.1016\/j.bjorl.2026.101772_bib0100","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genetics."},{"key":"10.1016\/j.bjorl.2026.101772_bib0105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.thromres.2021.08.026","article-title":"Genetically predicted obesity and risk of deep vein thrombosis","volume":"207","author":"Tan","year":"2021","journal-title":"Thrombosis Res."},{"key":"10.1016\/j.bjorl.2026.101772_bib0110","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.884298","article-title":"Genetic predisposition of anti-cytomegalovirus immunoglobulin G levels and the risk of 9 cardiovascular diseases","volume":"12","author":"Tan","year":"2022","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0115","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genetics."},{"key":"10.1016\/j.bjorl.2026.101772_bib0120","first-page":"77","article-title":"Meniere\u2019s disease","volume":"82","author":"Gibson","year":"2019","journal-title":"Adv Otorhinolaryngol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031448","article-title":"Pleiotropic, unique and shared responses elicited by IL-6 family cytokines in human vascular endothelial cells","volume":"23","author":"Lindkvist","year":"2022","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.bjorl.2026.101772_bib0130","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1002\/jcp.26210","article-title":"C\u2010C motif chemokine ligand 23 abolishes ER stress\u2010and LPS\u2010induced reduction in proliferation of bovine endometrial epithelial cells","volume":"233","author":"Lim","year":"2018","journal-title":"J Cell Physiol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0135","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/jmv.25460","article-title":"Immune and cytokine\/chemokine responses of PBMCs in rotavirus\u2010infected rhesus infants and their significance in viral pathogenesis","volume":"91","author":"Zhou","year":"2019","journal-title":"J Med Virol."},{"key":"10.1016\/j.bjorl.2026.101772_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fneur.2018.00431","article-title":"Betahistine treatment in a cat model of vestibular pathology: pharmacokinetic and pharmacodynamic approaches","volume":"9","author":"Tighilet","year":"2018","journal-title":"Front Neurol."},{"issue":"3","key":"10.1016\/j.bjorl.2026.101772_bib0145","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genetics."}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869426000212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869426000212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:18:53Z","timestamp":1777015133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869426000212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1808869426000212"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2026.101772","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically predicted plasma metabolites mediate the relation between inflammatory factors and Meniere's disease","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2026.101772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101772"}}