{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:10:34Z","timestamp":1778829034095,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020206","name":"Health Commission of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bjorl.2026.101779","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:08:39Z","timestamp":1773137319000},"page":"101779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A bioinformatics analysis revealing autophagy related DEGs in head and neck squamous cell carcinoma: expanding insights into lipid metabolism"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3936-3683","authenticated-orcid":false,"given":"Yi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-2336","authenticated-orcid":false,"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjorl.2026.101779_bib0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.bjorl.2026.101779_bib0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer."},{"issue":"Database issue","key":"10.1016\/j.bjorl.2026.101779_bib0015","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bjorl.2026.101779_bib0020","article-title":"Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers [published correction appears in Nat Commun","volume":"10","author":"Ando","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.bjorl.2026.101779_bib0025","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1158\/1078-0432.CCR-12-2647","article-title":"A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation","volume":"19","author":"Lohavanichbutr","year":"2013","journal-title":"Clin Cancer Res."},{"key":"10.1016\/j.bjorl.2026.101779_bib0030","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1002\/ijc.29649","article-title":"The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer","volume":"137","author":"Wichmann","year":"2015","journal-title":"Int J Cancer."},{"key":"10.1016\/j.bjorl.2026.101779_bib0035","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bjorl.2026.101779_bib0040","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS."},{"key":"10.1016\/j.bjorl.2026.101779_bib0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics."},{"key":"10.1016\/j.bjorl.2026.101779_bib0050","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bjorl.2026.101779_bib0055","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.bjorl.2026.101779_bib0060","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.bjorl.2026.101779_bib0065","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell."},{"key":"10.1016\/j.bjorl.2026.101779_bib0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2012.12.016","article-title":"Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy","volume":"152","author":"Kim","year":"2011","journal-title":"Cell."},{"key":"10.1016\/j.bjorl.2026.101779_bib0075","first-page":"128","article-title":"GSK3\u03b2 regulates autophagy by modulating LKB1-AMPK signaling in neurons","volume":"34","author":"Wei","year":"2013","journal-title":"Neurobiol Aging."},{"key":"10.1016\/j.bjorl.2026.101779_bib0080","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science."},{"key":"10.1016\/j.bjorl.2026.101779_bib0085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb2082","article-title":"Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation","volume":"12","author":"Gao","year":"2010","journal-title":"Nat Cell Biol."},{"key":"10.1016\/j.bjorl.2026.101779_bib0090","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1158\/0008-5472.CAN-05-1021","article-title":"Kinase-inactive glycogen synthase kinase 3\u03b2 promotes Wnt signaling and mammary tumorigenesis","volume":"65","author":"Farago","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bjorl.2026.101779_bib0095","first-page":"7749","article-title":"GSK3\u03b2 inhibition enhances the therapeutic efficacy of androgen receptor antagonists in prostate cancer","volume":"5","author":"Wang","year":"2014","journal-title":"Oncotarget."},{"key":"10.1016\/j.bjorl.2026.101779_bib0100","first-page":"869","article-title":"Glycogen synthase kinase 3\u03b2 promotes liver cancer cell proliferation and migration through the regulation of Snail","volume":"35","author":"Wang","year":"2016","journal-title":"Oncol Rep."},{"key":"10.1016\/j.bjorl.2026.101779_bib0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.124.325187","article-title":"GSK3\u03b2 deficiency expands obese adipose vasculature to mitigate metabolic disorders","volume":"136","author":"Wang","year":"2025","journal-title":"Circ Res."},{"key":"10.1016\/j.bjorl.2026.101779_bib0110","first-page":"7552","article-title":"GSK3\u03b2 promotes cell proliferation and tumorigenesis through upregulation of fatty acid synthase in human hepatocellular carcinoma","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.bjorl.2026.101779_bib0115","first-page":"2326","article-title":"GSK3\u03b2 suppresses lipogenesis and lipid accumulation in prostate cancer cells through inhibitory phosphorylation of SREBP-1","volume":"4","author":"Li","year":"2013","journal-title":"Oncotarget."}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869426000285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869426000285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:39:59Z","timestamp":1778827199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869426000285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1808869426000285"],"URL":"https:\/\/doi.org\/10.1016\/j.bjorl.2026.101779","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bioinformatics analysis revealing autophagy related DEGs in head and neck squamous cell carcinoma: expanding insights into lipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjorl.2026.101779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"101779"}}